DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and HECTD1

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_056197.3 Gene:HECTD1 / 25831 HGNCID:20157 Length:2610 Species:Homo sapiens


Alignment Length:1436 Identity:250/1436 - (17%)
Similarity:448/1436 - (31%) Gaps:490/1436 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 TFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQD----- 153
            |.|..:|.|...||.......:          .::||..:|:.:|:...:..|:..|.:.     
Human   801 TAETSLGSEFVTGWTGKRGRKL----------KSKLEKTKQKVRTMARDLYDDHFKAVESMPRGV 855

  Fly   154 ---------QLENKREMFDVKQ----------------QRLLWAQEEYNHLKLAASRSSLCSSSS 193
                     |||:..|:...:|                :.|:...::.|.:    |...:|||. 
Human   856 VVTLRNIATQLESSWELHTNRQCIESENTWRDLMKTALENLIVLLKDENTI----SPYEMCSSG- 915

  Fly   194 SMSRHDPELLRADLMLARERVH-QLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAE 257
                    |::|.|.:....:. .:||:.:.:...|:.    ..|.:|..|...:|..... |.:
Human   916 --------LVQALLTVLNNSMDLDMKQDCSQLVERINV----FKTAFSENEDDESRPAVAL-IRK 967

  Fly   258 VHAIRE--EMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDL 320
            :.|:.|  |.|.:|.....|.....:::...::.:.|             .:|       .:|.|
Human   968 LIAVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLE-------------RAP-------GETAL 1012

  Fly   321 CGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEP-GQLESDKDRILLIQEKE 384
            ...:|..|                                   ::|| ..:||.:..:|.:..|:
Human  1013 IDRTGRML-----------------------------------KMEPLATVESLEQYLLKMVAKQ 1042

  Fly   385 KLLNDLNSISLKSRSEEEKRVIHQTRHKLEE---------DLKEAYEANNTCVANR--LRFHEEK 438
            ....|.:|.....:..|.:..|.:.:|..:|         :.|.|||..|......  :...|.:
Human  1043 WYDFDRSSFVFVRKLREGQNFIFRHQHDFDENGIIYWIGTNAKTAYEWVNPAAYGLVVVTSSEGR 1107

  Fly   439 QLLLDKLQEALKSTKLLEERLKSFSSESTFSISSG------------------SSLGSLSTASSK 485
            .|...:|::.|...........:....:.|:|..|                  |:|.:.....||
Human  1108 NLPYGRLEDILSRDNSALNCHSNDDKNAWFAIDLGLWVIPSAYTLRHARGYGRSALRNWVFQVSK 1172

  Fly   486 SALSFTDIY--IDPFAVDSPIDVV--------DLRR--RSQRLFQ--QHQQQRLH---------- 526
            ...::|.:|  :|..:::.|....        |.::  |..|:.|  ::...:.|          
Human  1173 DGQNWTSLYTHVDDCSLNEPGSTATWPLDPPKDEKQGWRHVRIKQMGKNASGQTHYLSLSGFELY 1237

  Fly   527 -PVHPVLQQQ-----QSAEVTLSPRSSLSMETPPASPMKYNA-GA-------------DQTPQA- 570
             .|:.|.:.|     :.||..|..:..|..    :..:||.. ||             |.:||. 
Human  1238 GTVNGVCEDQLGKAAKEAEANLRRQRRLVR----SQVLKYMVPGARVIRGLDWKWRDQDGSPQGE 1298

  Fly   571 ---------------------------------LKEEPTYANALPAPPAYTAPPPVPISGVRARP 602
                                             ||..|.|     .|....:|.||         
Human  1299 GTVTGELHNGWIDVTWDAGGSNSYRMGAEGKFDLKLAPGY-----DPDTVASPKPV--------- 1349

  Fly   603 YDLDSTVLDCMMLEAKLQKLNMGTPLNLA---------------VAPLSPIS------EKPSLLD 646
               .|||.......:.|.|.|.....:.|               ||..|.||      |:.|.:.
Human  1350 ---SSTVSGTTQSWSSLVKNNCPDKTSAAAGSSSRKGSSSSVCSVASSSDISLGSTKTERRSEIV 1411

  Fly   647 LPQEMLSRS---------SSTSNTRSV----SAAVSNESVAGDSGVFEASRAHLPRK------EL 692
            :...::|.:         ||..|....    |::.|..::..::|...|.|...|..      |.
Human  1412 MEHSIVSGADVHEPIVVLSSAENVPQTEVGSSSSASTSTLTAETGSENAERKLGPDSSVRTPGES 1476

  Fly   693 AQVQIGLKYLKQEGVLVVS-------------LERANNLL---ALWTASADNSQVYLRAALLPNS 741
            :.:.:|:..:....|..||             ...|:|.|   :|..|.|..|.    :|.:|| 
Human  1477 SAISMGIVSVSSPDVSSVSELTNKEAASQRPLSSSASNRLSVSSLLAAGAPMSS----SASVPN- 1536

  Fly   742 LTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDS 806
            |:|..|.:|..|.:.|.|..                         :......:.:|.:..:...:
Human  1537 LSSRETSSLESFVRRVANIA-------------------------RTNATNNMNLSRSSSDNNTN 1576

  Fly   807 TLKWYNVLSSKFIP-----SFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTS 866
            || ..||:|:...|     ||.:|..|.|::....:..:.:::.|........|...:::::.|:
Human  1577 TL-GRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTT 1640

  Fly   867 TLTRNQAPCMELQE---------------QMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVS 916
            :||...:.....||               .:.|||.....|.||   |::||:.|::..:.|...
Human  1641 SLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDEDLPEP---DEEDDENEDDNQEDQEYE 1702

  Fly   917 DVGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSEAFSKN 981
            :|.::...|     ||......:|...:...:.||:...|..    .||:...:         :.
Human  1703 EVMILRRPS-----LQRRAGSRSDVTHHAVTSQLPQVPAGAG----SRPIGEQE---------EE 1749

  Fly   982 RYNCRLNRS---DSD-------SAMHCGVAPHTFQRGAAERRSLRF------HSK---------A 1021
            .|..:..|.   |.|       ||:.....|...:....:...|..      ||:         :
Human  1750 EYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTPHSELLEEVECTPS 1814

  Fly  1022 PKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQ---NLK-----------------E 1066
            |:....|..|.: .|:.::||.|....|.:::...::.:|.   |:|                 |
Human  1815 PRLALTLKVTGL-GTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEPTYTIMYRE 1878

  Fly  1067 VLQKACENKDPLVAAWAIE-------------NEEFQRLVARADPAKCPEERQLQKLLMKTAKEI 1118
            :.....|.::..:..|:||             |:....|...||.|.....:     |..|.|.|
Human  1879 MKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWK-----LTGTNKSI 1938

  Fly  1119 HKLRKTKVPKGCPDLV-SFKEKITFFTRKGL---SVPELPSEFTL-------------------- 1159
            .|.|      .|..|: ::|:.....|:.||   ::..|.|...|                    
Human  1939 RKNR------NCSQLIAAYKDFCEHGTKSGLNQGAISTLQSSDILNLTKEQPQAKAGNGQNSCGV 1997

  Fly  1160 ----------------PEANPIEEEEEEEDENEFYNSAETAIAINTALVASSNRNKNLSEHPHRA 1208
                            |.:...:|:.:|:.:..|.....|:..|.|.::..       .|.|...
Human  1998 EDVLQLLRILYIVASDPYSRISQEDGDEQPQFTFPPDEFTSKKITTKILQQ-------IEEPLAL 2055

  Fly  1209 TSGAVP 1214
            .|||:|
Human  2056 ASGALP 2061

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122
WW 103..132 CDD:278809 4/28 (14%)
C2_Kibra 693..813 CDD:176062 24/135 (18%)
HECTD1NP_056197.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..269
Ank_2 366..457 CDD:403870
ANK repeat 366..393 CDD:293786
ANK 1 395..424
ANK repeat 396..426 CDD:293786
ANK 2 426..455
ANK repeat 428..457 CDD:293786
ANK 3 459..491
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..513
ANK 4 579..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..657
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..748
Sad1_UNC 1107..1240 CDD:400199 19/132 (14%)
MIB_HERC2 1277..1335 CDD:399589 7/57 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1343..1406 15/74 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1433..1483 8/49 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1496..1515 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1592..1611 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1674..1757 21/103 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797 2/19 (11%)
BTHB 1892..1965 CDD:408209 20/83 (24%)
K-box 2029..2103 10/40 (25%)
HECTc 2131..2608 CDD:238033
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2297..2318
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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