DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and Plekha5

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_647556.1 Gene:Plekha5 / 246237 RGDID:621175 Length:1281 Species:Rattus norvegicus


Alignment Length:1493 Identity:277/1493 - (18%)
Similarity:458/1493 - (30%) Gaps:524/1493 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 LPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCV------GDELPMGWEESYDPN 114
            ||..|.......|:.::|:...|.||||       .|.|.|..|      ..:||.||||:|...
  Rat    13 LPRSWTYGITRGGRVFFINEEAKSTTWL-------HPVTGEAVVTGHRRQSTDLPTGWEEAYTFE 70

  Fly   115 IGPYYINH----------------------------LAQSTQLEDPRQEWKTVQE----QMLSDY 147
            ...|||||                            :|..|..|...:....:.|    .|.|||
  Rat    71 GARYYINHNERKVTCKHPVTGQPSQDNCIFVVNDQTVATMTSEEKKERPISMINEASNYNMASDY 135

  Fly   148 ----------LSAAQDQLEN--KREMFDVKQQ------RLLWA-QEEYNHLKLAASR----SSLC 189
                      .|.|..::.|  ||.. .:|:.      |..|. :::...:||...|    |.||
  Rat   136 TVHPMSPVGRTSRASKKVHNFGKRSN-SIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLC 199

  Fly   190 SSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISY--TERGMNTLYSVGEKINARENGC 252
            .......:.  |.:...::|...::..|..| .||....::  ....|.|.|.           |
  Rat   200 LFYYRDEKE--EGILGSILLPSFQIAMLTAE-DHINRKYAFKAAHPNMRTYYF-----------C 250

  Fly   253 YDIA-EVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVAS 316
            .|.. |:....:.||..  :||..|.|:.......|                      |::...|
  Rat   251 TDTGKEMELWMKAMLDA--ALVQTEPVKRITFNFRV----------------------DKITTES 291

  Fly   317 QTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQ 381
                  :|.:..|.......:.:.:.|..:..|.|.|::::.|...||.  |..:..:||     
  Rat   292 ------ASTKETNNIPNHRVLIRPEVQNNQKNKEISKIEEKRALEAERY--GFQKDGQDR----- 343

  Fly   382 EKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFH----------- 435
                .|..:||:.|.|                   |...||:...|....:.:.           
  Rat   344 ----PLTKINSVKLNS-------------------LPSEYESGPACPPQNIHYRPINVNNSDSKA 385

  Fly   436 ---------------------EEKQLL-----LDKLQEALKSTK--LLEERLKSFSSESTFSISS 472
                                 |..:::     :.:|::.:|..|  .|||..:...|..|...:.
  Rat   386 VNVSLADVRGGSHPNTGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNM 450

  Fly   473 GS--------------SLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQR------LF 517
            .|              :|...|....:|..|.|     |...:......:.:|||.|      |:
  Rat   451 PSHRAQILARYPEGYRTLPRNSKTRPESICSVT-----PSGHEKTGPGAEEKRRSMRDDTMWQLY 510

  Fly   518 QQHQQQRLH-----PVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQ--TPQALKEEP 575
            :..|:|..|     |.|..|    |:...:...|..:|.:.|.||....|.|.|  :||.     
  Rat   511 EWQQRQFYHKQSTLPRHSCL----SSPKAMGKVSDQTMHSIPTSPSHVPAAAYQGFSPQR----- 566

  Fly   576 TYANALPAP-------------PAYTAPPPVPISGVRARPYDLDSTVLDCMMLEA-KLQKLNMGT 626
            ||.:.:.:|             |.:  |..|.:...|:.|..|        .|:| ..|.|:..|
  Rat   567 TYRSEVSSPIQRGDVTIDRRHRPHH--PKHVYVPDRRSMPAGL--------ALQAVSPQSLHGRT 621

  Fly   627 PLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKE 691
            |..|.:.          |:.|.::....||...:|.:....:..|             ||.|:.|
  Rat   622 PEELTLL----------LIKLRRQQAELSSIREHTLAQLMQLKLE-------------AHSPKNE 663

  Fly   692 -----LAQVQIGLKYLKQEGVLVVSLE------------------RANNLLALWTASADNSQVYL 733
                 |.:..|.|.:..:|...::::.                  |..|.::|:..|.|..:   
  Rat   664 ILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKNKISLYCLSQDECR--- 725

  Fly   734 RAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISM 798
                  .:|...|.:                .:.:|..|::..         ::::::..::..:
  Rat   726 ------GTLYKYRPE----------------EVDIDAKLSRLC---------EQDKVVRALEEKL 759

  Fly   799 AEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGN------NREESSDE 857
            .:.:.|..||:                     .|..:|:.....||.||..      .|::..:.
  Rat   760 QQLHKEKYTLE---------------------QALLSASQEIEMNADNPAAIQTVVLQRDDLQNG 803

  Fly   858 STITSSQTS--------------------TLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDD 902
            ...|..:.|                    |:||||     :|:|:  :.||       |...:..
  Rat   804 LLSTCRELSRATAELERAWREYDKLEYDVTVTRNQ-----MQDQL--DRLG-------EVQSESA 854

  Fly   903 DDEEEELDDKQL--VSDVGLMNSSSMLHAYLQNMKQEFADKETNT--DRAY--LPEKSRGQSQLM 961
            ..:..:: .|:|  :.||  |..       |...||:....||..  .:.:  :..||..:..:.
  Rat   855 GIQRAQI-QKELWRIQDV--MEG-------LSKHKQQRGSSETGLAGPKPFPAVKYKSEEEEVVP 909

  Fly   962 DDRPVKRSQTFT---------PSEA------------------------FSKNRYNC----RLNR 989
            ...|:.||..||         ||::                        :.:|..:|    ||.:
  Rat   910 PRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKSHQVQGYPRNGSHCGPDYRLYK 974

  Fly   990 SDSDSAMHCGV---------APHTFQRGAAERRS-------LRFHSKAPKSVTKLHHTHIPRTSL 1038
            |:.:......|         .|.:.......|.|       ||..|..|:|.|...:..:.:|..
  Rat   975 SEPELTTVAEVDESNGEEKSEPASEAEAPVVRGSHFPVGVPLRTKSPTPESSTIASYVTLRKTKK 1039

  Fly  1039 DLELDLQAQHSKLYFL------------NDQIAKLQNLKEVLQKAC--ENKDPLVAAWAIENEEF 1089
            .:||..:...|.:..|            .:|:.:::.    .|:||  |.|..|....|.:....
  Rat  1040 MVELRTERPRSAVEQLCLAESTRPRMTVEEQLERIRR----HQQACLREKKKGLNVLSASDPSPS 1100

  Fly  1090 QR-LVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDL-------------------V 1134
            |. ...|..|::.|:..:..    ...||:..:.:..  .|.||.                   |
  Rat  1101 QSPSSVRDSPSRVPQTVRRD----DNTKELDAVHREN--DGKPDYDTSAAETAHPEEAEPQSADV 1159

  Fly  1135 SFKEKIT---FFTRKGLSVPELPSEFTLPEANPIEEEEEEEDENEFYNSAETAIAINTALVASSN 1196
            ..|.|.|   |:  :.|..||..:..|..|....|.:||:..|....:..|.|...|........
  Rat  1160 GRKLKRTESIFY--EMLYTPEPLNGLTSEEVMAKERQEEQVPEGAVCSLQEEAAMANHQAEGPPE 1222

  Fly  1197 RNKNLSEHPHRATSGAVPKIPAPVVTPAATPAATPAATPAATSAATPAATPVVSPAAQPDAKP 1259
            ..::|.|......|..    |||         .||........:.:|  :|..|.||.|...|
  Rat  1223 EAESLHEEEEALASCE----PAP---------ETPRENQTTVKSLSP--SPDSSTAADPPTPP 1270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122 9/29 (31%)
WW 103..132 CDD:278809 15/56 (27%)
C2_Kibra 693..813 CDD:176062 15/137 (11%)
Plekha5NP_647556.1 WW 13..42 CDD:278809 10/35 (29%)
WW 59..88 CDD:278809 12/28 (43%)
PH_PEPP1_2_3 165..268 CDD:270068 22/118 (19%)
PH 171..267 CDD:278594 22/109 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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