DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and Magi3

DIOPT Version :10

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_620784.3 Gene:Magi3 / 245903 RGDID:621362 Length:1470 Species:Rattus norvegicus


Alignment Length:1367 Identity:280/1367 - (20%)
Similarity:453/1367 - (33%) Gaps:377/1367 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYY 119
            |||..|::|....|..|:|||..|.|||||||.| .|.:..|||...|||.|||:..||..|.||
  Rat   297 PLPKNWEMAYTDTGTIYFIDHNTKTTTWLDPRLC-KKAKAPEDCEDGELPYGWEKIEDPQYGTYY 360

  Fly   120 INHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAAS 184
            ::||.|.||.|:|.:|.|. ::|:         .|.|......||::...   ..:.:.||....
  Rat   361 VDHLNQKTQFENPVEEAKR-KKQI---------GQAETHSAKTDVERAHF---TRDPSQLKGVLV 412

  Fly   185 RSSLCSSSSSM-------SRHDPELLRADLMLARERVHQLKQELTHITNDIS------YTERG-- 234
            |:||..|:...       .|.|..|...:::.........|.....:..||:      :|...  
  Rat   413 RASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKMAPGDVIVDINGNCVLGHTHADVV 477

  Fly   235 -MNTLYSVGEKIN---ARENGCYDIAE---VHAIREEMLKVHKSLVSGE---KVREELMRSLVQI 289
             |..|..|.:.:|   .|.....|.:|   |..:....:...:||..||   ..::..:.::|..
  Rat   478 QMFQLVPVNQYVNLTLCRGYALPDDSEDPVVDIVAATPVINGQSLAKGEACMSTQDFKLGAMVLD 542

  Fly   290 KNELGRQQISEENSDLASPFD----RVCVASQTDLCGSSGENL---------NG----------G 331
            :|....:.:|.::  |..|.|    |..:||.    |||...|         .|          |
  Rat   543 QNGKSGKLLSSDH--LNGPSDSNEQRASLASS----GSSQPELVTIPLVKGPKGFGFAIADSPTG 601

  Fly   332 ARFAEMAKTKW----QYAEWRKHIKKLQQQLADHVERIEP-GQLESDKDRILLI--------QEK 383
            .:...:..::|    |..:..|.|.....|...|::.:|. .|.....|..|||        .:.
  Rat   602 QKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKT 666

  Fly   384 EKLLNDL--NSISLKSRSEEEKR-------VIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQ 439
            .|:..|.  .|.||::.:|...:       :|.....||  |..|.|..:.|       .:|:|.
  Rat   667 AKMKTDTKETSGSLETINEPTPQPMPFPPSIIRSGSPKL--DPSEVYLKSKT-------LYEDKP 722

  Fly   440 LLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSS------LGS---LSTASSKSALSFTD--I 493
                      .:||.|:..|:...|...|.:..|..      :|:   |..|.....|...|  :
  Rat   723 ----------PNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELM 777

  Fly   494 YID--PFAVDSPIDVVDLRRRSQR-----------LFQQHQQQRLHPVHPVLQQQQSAEVTLSPR 545
            .||  |....|...|:||...:.|           :|...:|       |..:..|:...:.|||
  Rat   778 CIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQ-------PEDESPQAFSQSGSPR 835

  Fly   546 -SSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTV 609
             :...:.|..|....|:....:     ||...:...:..  :.:.|||    ||           
  Rat   836 LNRTELPTRSAPQESYDVILQR-----KENEGFGFVILT--SKSKPPP----GV----------- 878

  Fly   610 LDCMMLEAKLQKLNMGTPLN----LAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSN 670
                 :..|:.::..|:|.:    |.|..........|::||..:.:.:....:........|:.
  Rat   879 -----IPHKIGRVIDGSPADRCGRLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAE 938

  Fly   671 ESVAG-DSG--------------VFEASRAHLPRKELA-QVQIGL-------------KYLKQEG 706
            |...| .||              :.:|...|:|....| :.::|.             |:|.|..
  Rat   939 EEHHGPPSGTNSARQSPALQHRPMGQAQATHIPGDRTALEGEVGKDVCSSYRHSWSDHKHLAQPD 1003

  Fly   707 VLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKL 771
            ..|:|:                             :.|..:::||.:           |:.|:  
  Rat  1004 TAVISV-----------------------------VGSRHSQSLGCY-----------PVELE-- 1026

  Fly   772 LTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDI---PS---T 830
              :..:....::.|.||..:|...:.:||..|.        :...:.....:.::|   |:   |
  Rat  1027 --RGPRGFGFSLRGGKEYNMGLFILRLAEDGPA--------IKDGRIHVGDQIVEINGEPTQGIT 1081

  Fly   831 SAAAAAAAVAASNAP----NPGNNR-EESSDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLG 890
            ...|.....|..|..    .||... .:..|....:.|.::.:...|.|.:......|.......
  Rat  1082 HTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDIYSPSSSNVIYDEQPPPLPSSHSAATFEESHV 1146

  Fly   891 PLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKSR 955
            |:.|.........::.|||.|.       :....|.|:.....||.:...|..:...   |.:|.
  Rat  1147 PVTEDSLIRVQTCEKAEELKDT-------VQEKKSTLNGSQPEMKYQSVQKNVSKKD---PSRSH 1201

  Fly   956 GQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHSK 1020
            |..    |:.:.:.:.                           ||...  .|.|:.::|:..||:
  Rat  1202 GHG----DKNLPKGEN---------------------------GVTRR--GRSASPKKSVNRHSE 1233

  Fly  1021 APKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIE 1085
            .       |...|||   .|..|.:.: |:...|:.:  |.:|..:|..||...:||        
  Rat  1234 E-------HLEKIPR---PLRSDPKGK-SRDRSLSPR--KGENKGQVTIKAGSGQDP-------- 1277

  Fly  1086 NEEFQRLVARADPAKCPEERQLQKL----LMKT---AKEIHKLRKTKVPKGCPD-LVSFKEKITF 1142
                    .|.|..:....|:.||:    |..|   ..|....|...:....|: |...||| :.
  Rat  1278 --------CRKDRGRSSSPRKQQKIGGNSLSNTEGKLSEAGSRRAAGLSSDSPEQLPEGKEK-SG 1333

  Fly  1143 FTRKGLSV----------PE----------LPSEFTLPEANPIEEEEE--------EEDENEFYN 1179
            .:||.|.:          ||          |||:.|...|:.:..|:|        |...::...
  Rat  1334 VSRKDLKLSQLGKNRTRSPEKRSSKVDEASLPSKKTSDTASRVVSEKEKGRKPGTGERSRDKTGE 1398

  Fly  1180 SAETAIAINTALVASSNRNKNLSEHPHRA--TSGAVPKIPAPVVTPAATPAATPAATPAATSAAT 1242
            |.:|:....|............||...|.  .:|..|:..:||.....||.  |...|.|.....
  Rat  1399 SVQTSAKPLTQEAGEKMALSKASEVTDRGKERAGGAPESSSPVKKAPITPG--PWRVPRANKVTG 1461

  Fly  1243 PA 1244
            .|
  Rat  1462 TA 1463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122 15/29 (52%)
WW 103..132 CDD:459800 16/28 (57%)
C2_Kibra 693..813 CDD:176062 19/133 (14%)
Magi3NP_620784.3 PDZ0_MAGI-1_3-like 14..106 CDD:467212
Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:16316992 18..108
NK 125..>199 CDD:450170
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266
HUL4 <211..>373 CDD:227354 40/76 (53%)
WW 299..329 CDD:238122 15/29 (52%)
WW 345..375 CDD:238122 16/29 (55%)
PDZ1_MAGI-1_3-like 411..495 CDD:467213 15/83 (18%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 15/81 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..575 8/30 (27%)
PDZ2_MAGI-1_3-like 577..658 CDD:467214 15/80 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..700 7/34 (21%)
PDZ3_MAGI-1_3-like 727..811 CDD:467215 18/83 (22%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 17/81 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..847 7/35 (20%)
PDZ4_MAGI-1_3-like 851..936 CDD:467216 16/111 (14%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 16/113 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976 7/36 (19%)
PDZ5_MAGI-1_3-like 1020..1102 CDD:467217 15/104 (14%)
PTZ00112 1115..>1405 CDD:240274 70/362 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1124..1146 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1470 75/372 (20%)
Blue background indicates that the domain is not in the aligned region.

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