DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and Plekha7

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:XP_017177675.1 Gene:Plekha7 / 233765 MGIID:2445094 Length:1359 Species:Mus musculus


Alignment Length:1467 Identity:261/1467 - (17%)
Similarity:484/1467 - (32%) Gaps:433/1467 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 LPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYI 120
            ||:.|......||:.::|:...:.||||.||.  .:|......:..:||.||||.:......::|
Mouse    10 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRT--GEPVNSGHMIRSDLPRGWEEGFTEEGASFFI 72

  Fly   121 NHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHL------ 179
            :|..|:|....|      |..|                   |..:....:..:|.:.|:      
Mouse    73 DHNQQTTTFRHP------VTGQ-------------------FSSENSEYVLREEPHPHMSKPERN 112

  Fly   180 ----KLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQL--KQELTHITNDISYTERG-MNT 237
                .:.:..|:..::|:..::..|:::::.     .:||..  :.:......::....|| ::.
Mouse   113 QRPSSMVSETSTAGTTSTLEAKPGPKIVKSS-----SKVHSFGKRDQAIRRNLNVPVVVRGWLHK 172

  Fly   238 LYSVGEKI-----------------NARENG--------CYDIAEVHAIREEMLKVH--KSLVSG 275
            ..|.|.::                 ::||..        .|.|:.| |..:.:.:.:  |::.:|
Mouse   173 QDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPV-APEDRISRKYSFKAVHTG 236

  Fly   276 EKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKT 340
                   ||:|:......|.|.   |:|.:.:.:          ....:.|::|...|....|..
Mouse   237 -------MRALIYSTTTAGSQM---EHSGMRTYY----------FSADTLEDMNAWVRAMNQAAQ 281

  Fly   341 KWQYAEWRKHIKKLQQQL---ADHVE------RIEPGQ--------------------------- 369
            ....:..|:.:.|:::|.   |:|.:      .:.||.                           
Mouse   282 VLSRSSLRRDVDKVERQAMPQANHTDACQECGHVGPGHSRDCPRRGYEDSYGFNRREQEEERFRA 346

  Fly   370 ----LESDKDRI-----LLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAY---E 422
                ||..:||.     .|..|::.|..||.......:::.:         :.|::....|   |
Mouse   347 QRDPLEGRRDRSKARSPYLPAEEDALFVDLPGGPRGQQAQPQ---------RAEKNGVPPYGLGE 402

  Fly   423 ANNTCVANRL-------RFHEEKQLLLDKLQEALKSTK------LLEERLKSFSSESTFSI---- 470
            .|.|....|.       ..|.:::..|.:.:...|:.|      .|::.|.........|.    
Mouse   403 QNGTNGYQRTAPPRANPEKHSQRKTGLAQAEHWTKAQKGDGRSLPLDQTLPRQGPSQPLSFPENY 467

  Fly   471 -SSGSSLGSLSTASSKSALSFTDIYIDPFAVD--SPIDVVDLRRRSQR------LFQQHQQQRLH 526
             |...|...||.:||....:....|  .:|.|  |.:.:....||:.|      |::..|:|:..
Mouse   468 QSLPKSTRHLSGSSSPPPRNLPSDY--KYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFR 530

  Fly   527 ---PVHPVLQQQQSAEVTLSPRSSLSMETP-----PASPMKYNAGADQTPQALKEEPTYANALPA 583
               |..|:  ...|.|.|...||...:|.|     |.||      :|..|             |.
Mouse   531 HGSPTAPI--GAGSPEFTEQGRSRSLLEVPRSISVPPSP------SDIPP-------------PG 574

  Fly   584 PPAYTAP--PPVPISGVRARPYDLDSTV------------------------------------- 609
            ||....|  |..|...|..:|.:...:|                                     
Mouse   575 PPRPFPPRRPHTPAERVTVKPPEQRRSVDISLGGSPRKARGHAAKNSSHVDRRSMPSMGYMTHTV 639

  Fly   610 ------------LDCMMLEAKLQKLNMGTPLNLAVAPL-------SPISEKPSLLDLPQEMLSRS 655
                        |..::...:..:..:.:..|.||..|       .......:.|.|.:::....
Mouse   640 SAPSLHGKSLEELSLLLTRLQRHQSKLASVRNFAVGQLLHHYLTFPACQADDTYLQLKKDLEYLD 704

  Fly   656 SSTSNT------------RSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLK---YLKQE 705
            ....|.            :|........|:.|...:.:.|   |...::|:..|.:|   :.:|:
Mouse   705 LKIKNNEPLINVLYKVLKKSARGCRPGRSMTGRDLLKDRS---LKPMKIAESDIDVKLSIFCEQD 766

  Fly   706 GVL-------------VVSLERANNLLALWTASADNSQVYL-----RAALLPNSLTSIRTK---- 748
            .:|             ...||....:|...|....:...:|     :..||...|..||.:    
Mouse   767 RILQDLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRE 831

  Fly   749 ------ALGDFQKPVFNDTFAVPITLDKLLTKS---------------LQVTVVTMTGQKEE--- 789
                  |..::.| :..|...:..||.:...::               ::..:..::..||.   
Mouse   832 STEMENAWNEYLK-LEKDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVMAGLSANKENYRV 895

  Fly   790 IIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREES 854
            ::|:|:      |||..|           :|.|....:||.|...:..|:..|...:|.....| 
Mouse   896 LVGSVK------NPERKT-----------VPLFPHPSVPSLSPTESKPALQPSPPTSPVRTPLE- 942

  Fly   855 SDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDE--------EEELDD 911
              .......||....|...|  :|::.|:       ||..|..:....:||        |....:
Mouse   943 --VRLFPQLQTYVPYRPHPP--QLRKVMS-------PLQSPTKAKPQAEDEAPPRPPLPELYSPE 996

  Fly   912 KQLVSDVGLMNSSSML-HAYLQNMKQEFADKETNTD-------------RAYLPEKSRGQSQLMD 962
            .|..:...|...:::: |..::.:|::..:::.:.:             |:|:.|..  .:.|..
Mouse   997 DQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDLKVELRSYVSEPE--LASLSG 1059

  Fly   963 DRPVKRSQTFTPSEAF--SKNRYNC----RLNRSDSDSAMHCGVAPH-TFQRGA-AERRSLRFHS 1019
            |.|       .||.:.  |::||..    .|:.|.|.......:||: |.:||. ||..|..| |
Mouse  1060 DVP-------QPSLSLVGSESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAENSSATF-S 1116

  Fly  1020 KAPKSVTKLHHTHIPRTSLDLE--LDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPL---V 1079
            :...::.:|:.....|..:..|  |:...:|.|......:....|..|..|..|.....||   :
Mouse  1117 RPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGEKTGLLSARYLSQPLPGDL 1181

  Fly  1080 AAWAIENEEFQRLVARA--DPAKCPEERQL--------------QKLLMKTAKEIHKLRKTKVPK 1128
            .:|..|.|...:|:.||  ...|..||..|              |...:..::|:.|..|..:|:
Mouse  1182 GSWKREQEFDLQLLERAAQGDRKDKEEGWLKVQATPVMELDLEPQDYDLDISRELSKPEKVSIPE 1246

  Fly  1129 GC----PDLVSFKEKITFFTRKGLSVPELPSEFTLPEANPIEEEEEE-EDENEFYNSAETAIAIN 1188
            ..    |:.....|::....:|...:..:.:..::....|:.::... .|.:......|..|.|:
Mouse  1247 RYVELDPEEPPSLEELQARYQKAEKIRNILARSSMCNLQPLGQDRNSLADLDSQLQEQERIINIS 1311

  Fly  1189 TALVA-SSNRNKNLSEH-----PHRA--TSGAVPKIP 1217
            .||.: :|.|:|.::..     |.:|  :|..||..|
Mouse  1312 YALASEASKRSKQVAVQQLALLPPKAPLSSRTVPPYP 1348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122 10/29 (34%)
WW 103..132 CDD:278809 10/28 (36%)
C2_Kibra 693..813 CDD:176062 28/168 (17%)
Plekha7XP_017177675.1 WW 10..39 CDD:366073 10/28 (36%)
WW 55..84 CDD:366073 10/28 (36%)
PH_PEPP1_2_3 158..280 CDD:270068 22/142 (15%)
Smc <692..>894 CDD:224117 30/205 (15%)
PHA03247 <903..1009 CDD:223021 26/128 (20%)
PRK10263 <912..>1118 CDD:236669 47/227 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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