Protein Alignment kibra and HECW1

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_016867371.1
• Gene: HECW1 / 23072
• HGNCID: 22195
• Length: 1639
• Species: Homo sapiens
• Alignment Length: 944
• Identity: 165/944 - (17%)
• Similarity: 282/944 - (29%)
• Gaps: 387/944 - (40%)

  Fly    18 HHLRPQQQ----QQQHHHHHQQQQQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINK 78
            |:.:|..|    :.:|||:..                 .|.|||..|:...|..|:.:|:||:|:
Human   839 HNSQPVSQLPSLRPEHHHYPT-----------------IDEPLPPNWEARIDSHGRVFYVDHVNR 886

  Fly    79 KTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQM 143
            .|||..|....|             |.|...|             ....|:|...:.::.:|.
Human   887 TTTWQRPTAAAT-------------PDGMRRS-------------GSIQQMEQLNRRYQNIQR-- 923

  Fly   144 LSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSM------------S 196
                                                .:|..||...|.|.|.            |
Human   924 ------------------------------------TIATERSEEDSGSQSCEQAPAGGGGGGGS 952

  Fly   197 RHDPELLRADLMLARE---------RVHQLKQE--LTHITNDISYTERGMNTLYSVGEKINAREN 250
            ..:.|..::.|.|.||         ::..|.|.  :..|||...:|....|  ||......:  :
Human   953 DSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHAN--YSAYRVFTS--S 1013

  Fly   251 GCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKN------------------ELGRQQ 297
            .|        ::..:|||.:...:.|:.:..  |.||...|                  :.|:..
Human  1014 TC--------LKHMILKVRRDARNFERYQHN--RDLVNFINMFADTRLELPRGWEIKTDQQGKSF 1068

  Fly   298 ISEENSDLASPFD-RVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADH 361
            ..:.||...:..| |:.:        .:|...|              :...|:|:::|:...|.
Human  1069 FVDHNSRATTFIDPRIPL--------QNGRLPN--------------HLTHRQHLQRLRSYSAG- 1110

  Fly   362 VERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNT 426
                |..::..::...||.:....|:..:.|               |.:|   |.|..||  |:.
Human  1111 ----EASEVSRNRGASLLARPGHSLVAAIRS---------------QHQH---ESLPLAY--NDK 1151

  Fly   427 CVANRLRFHEEKQL--LLDKLQEALKSTKLLEERLKSFSSESTF---SISSGSSLGSLSTASSKS 486
            .||    |..:..:  :|.:.|.:|.....|.|::....:|...   .:|..:.|..|.:...:.
Human  1152 IVA----FLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEE 1212

  Fly   487 ALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSME 551
            .:|:..:                            |...||.:           :.|||.|
Human  1213 IMSYVPL----------------------------QAAFHPGY-----------SFSPRCS---- 1234

  Fly   552 TPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLE 616
             |.:||              :..|....|....|:               ||..|        .|
Human  1235 -PCSSP--------------QNSPGLQRASARAPS---------------PYRRD--------FE 1261

  Fly   617 AKL----QKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDS 677
            |||    :||. ..........:..|..:..||:
Human  1262 AKLRNFYRKLE-AKGFGQGPGKIKLIIRRDHLLE------------------------------- 1294

  Fly   678 GVFEASRAHLPRKELAQVQIGLKYLKQEGV----------LVVSLERANNLLALWTASADNS--- 729
            |.|....|: .||||.:.::.:.::.:||:          .::|.|..|....|:..||:::
Human  1295 GTFNQVMAY-SRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTV 1358

  Fly   730 QVYLRAALLPNSLTSIR--TKALG-----------DFQKPVFNDTFAVPIT------LDKLLTKS 775
            |:...:|.:.|.|...|  .:.||           .|.:|.:.....:|..      ||:...:|
Human  1359 QISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQS 1423

  Fly   776 LQ---------VTVVTMTGQKEEIIGTV----------QISMAEFNPE---DSTLKW-------- 810
            ||         :..:|.| ..||:.|.|          ...:.|.|.:   :..:||
Human  1424 LQWMKDNNITDILDLTFT-VNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQ 1487

  Fly   811 ---------YNVLSSKFIPSFESLDIPSTSAAAA 835
                     |.|:.|:.:..|::.::....|..|
Human  1488 QTEALVRGFYEVVDSRLVSVFDARELELVIAGTA 1521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	12/29 (41%)
		WW	103..132	CDD:278809	5/28 (18%)
		C2_Kibra	693..813	CDD:176062	34/190 (18%)
HECW1	XP_016867371.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900