DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Hace1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_006512697.1	Gene:	Hace1 / 209462	MGIID:	2446110	Length:	921	Species:	Mus musculus

Alignment Length:	790	Identity:	150/790 - (18%)
Similarity:	272/790 - (34%)	Gaps:	239/790 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 AQSTQL-EDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSS 187
            |::.:| ||......|:...:::|...:..:.|.|.:  |||   ...:.:.:.:.|.:||:
Mouse    18 ARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSK--FDV---NYAFGRVKRSLLHIAAN--- 74

  Fly   188 LCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGC 252
             |.|...:           ::|.::..:...|:::..|........|.....|...:.:|..|.|
Mouse    75 -CGSVECL-----------VLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNIC 127

  Fly   253 YDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQ------IKNELGR---------------Q 296
            .:        |.:..:|...|:|   |.||:..|||      :::.:|:               |
Mouse   128 NN--------EGLTAIHWLAVNG---RTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQ 181

  Fly   297 QISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADH 361
            .:.:..:|:..|                  |::|....         |...|:........:..|
Mouse   182 CLLDSGADINRP------------------NVSGATPL---------YFACRRVCLIFWTWIHSH 219

  Fly   362 VERIEPGQLESDKDRILLIQEKEKLLNDLNSIS-----LKSRSEEEKRVIHQTRHKL-------- 413
            .:|        |..:|||:: ..|.|.|.|.::     ::....:...|:.|...:|
Mouse   220 GQR--------DTAQILLLR-GAKYLPDKNGVTPLDLCVQGGYGQTCEVLIQYHPRLFQTIVQMT 275

  Fly   414 -EEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLG 477
             .|||:|          |.||      .:|..|.:..:|     :.||..:..:..:.::|..|.
Mouse   276 QNEDLRE----------NMLR------QVLQHLSQQSES-----QYLKILTGLAEVATTNGHKLL 319

  Fly   478 SLST---ASSKSALSFTDIYIDPFAV--DSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQS 537
            |||:   |..||.|....|:...|.:  .||.:.:|:.....:   ..:.|...|:..:......
Mouse   320 SLSSNYDAQMKSLLRIVRIFCHVFRIGPSSPSNGIDMGYNGNK---TPRSQVFKPLELLWHSLDE 381

  Fly   538 AEVTLSPRSSLSME--TPPASPMKYNAGADQTPQALKE-EPTYANALPAPPAYTAPPPVP----- 594
            ..|.::.....:.|  |...|.:....|.||...:|.. ||      |.|.:|.:.||.|
Mouse   382 WLVLIATELMKNKEDSTDITSILLKQKGQDQEAPSLSAFEP------PGPGSYESLPPGPGDSKP 440

  Fly   595 --ISGVRARPYDLDSTV-LDCMMLEAKLQKLNMGTPLNLAVAPLSP----------------ISE 640
              ::|.:....|....: :....|.|.:|...|.....:.....||                ::.
Mouse   441 EVLAGEQEASADCQDVISVTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNR 505

  Fly   641 KPS--------LLDLPQEMLSR---------------------SSSTSNTRSVSAAVSNES---V 673
            .|.        ||:.| |::||                     .|...::..|...||...   |
Mouse   506 NPKIIFDHFHFLLECP-ELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVSENDILLV 569

  Fly   674 AGDSGVFEASRAHLPRKELAQVQ--IGLKYLKQEGV---------LVVSLERANNLLALWTASAD 727
            ..|| :|.:|...:.:...|:::  |.:::..:||:         .::|.|..|...||:|.|||
Mouse   570 HRDS-IFRSSCEIVSKANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSAD 633

  Fly   728 ------NSQVYLRAALLPNSLTSIR--TKALG-----------DFQKPVFNDTFAVPI------T 767
                  ||..|:.    |:.|...|  .:.||           .|.:..:.....:|:      :
Mouse   634 GTTFQPNSNSYVN----PDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVAS 694

  Fly   768 LDKLLTKSLQ 777
            :|....|:||
Mouse   695 IDPEYAKNLQ 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	3/8 (38%)
		C2_Kibra	693..813	CDD:176062	27/121 (22%)
Hace1	XP_006512697.1	ANK repeat	66..95	CDD:293786	6/43 (14%)
		Ank_2	69..194	CDD:372319	27/168 (16%)
		ANK repeat	97..128	CDD:293786	5/30 (17%)
		ANK repeat	130..161	CDD:293786	10/33 (30%)
		ANK repeat	163..194	CDD:293786	4/48 (8%)
		Ank_2	168..263	CDD:372319	18/130 (14%)
		ANK repeat	196..233	CDD:293786	9/54 (17%)
		HECTc	566..915	CDD:238033	32/144 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900