DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and Nedd4

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001344927.1	Gene:	Nedd4 / 17999	MGIID:	97297	Length:	1207	Species:	Mus musculus

Alignment Length:	517	Identity:	118/517 - (22%)
Similarity:	191/517 - (36%)	Gaps:	161/517 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LPDGWDIAKDFDGKTYYIDHINKKTTWL------DPRD---CYTKPQTFEDCVGDELPMGWEESY 111
            ||.||:..:|..|::||:||.:|.|||.      |||.   .:.:.:|..:.:| .||.||||..
Mouse   727 LPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPRSKIPAHLRGKTDSNDLG-PLPPGWEERT 790

  Fly   112 DPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY 176
            ..:...::|||..:.||.||||     :|...::..........:.|.|.|    :|.|..|.:.
Mouse   791 HTDGRVFFINHNIKKTQWEDPR-----LQNVAITGPAVPYSRDYKRKYEFF----RRKLKKQTDI 846

  Fly   177 -NHLKLAASRSSLCSSS----SSMSRHDPELLRADLML-------------ARERVHQLKQELTH 223
             |..::...|:::...|    ..:.|.|  ||:|.|.:             |||....:.:|:
Mouse   847 PNKFEMKLRRANILEDSYRRIMGVKRAD--LLKARLWIEFDGEKGLDYGGVAREWFFLISKEM-- 907

  Fly   224 ITNDISYTERGMNTLYSVGE---------KINARENGCYD--------IAEVHAIREEMLKVHKS 271
                       .|..|.:.|         :||.....|.:        |..|..    |...|..
Mouse   908 -----------FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAG----MAVYHGK 957

  Fly   272 LVSGEKVR---EELMRSLVQIKN--ELGRQQISE-----ENS----DLASPFDRVCVASQTDLCG 322
            |:.|..:|   :.:::.|:.:.:  .:..:..|.     ||.    ||....|.       :|.|
Mouse   958 LLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDE-------ELFG 1015

  Fly   323 SSGEN--LNGGARFAEMAKTKWQY----AEWRKHIKKLQQQLADHVERIEPGQLE---SDKDRIL 378
            .:.::  ..||:......|.|.:|    .:|| .:.::|:|:|...|    |..|   .|..:|.
Mouse  1016 QTHQHELKTGGSEIVVTNKNKKEYIYLVIQWR-FVNRIQKQMAAFKE----GFFELIPQDLIKIF 1075

  Fly   379 LIQEKEKLLNDLNSISLKSRSEEEK---------RVIH-----------QTRHKLEE-------- 415
            ...|.|.|:..|..:.:....|..|         :|||           :.|.:|.:
Mouse  1076 DENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRV 1140

  Fly   416 ---DLKEAYEAN-------------------NTCVANRLRF--HEEKQLLLDKLQEALKSTK 453
               ...|.|.:|                   :||. |||..  :|....|.||||.|:::|:
Mouse  1141 PMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCF-NRLDLPPYESFDELWDKLQMAIENTQ 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/35 (43%)
		WW	103..132	CDD:278809	12/28 (43%)
		C2_Kibra	693..813	CDD:176062
Nedd4	NP_001344927.1	C2	<477..530	CDD:326325
		WW	574..602	CDD:238122
		WW	727..756	CDD:306827	14/28 (50%)
		WW	781..813	CDD:197736	15/36 (42%)
		HECTc	874..1203	CDD:214523	73/360 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900