Protein Alignment kibra and Nedd4

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001344927.1
• Gene: Nedd4 / 17999
• MGIID: 97297
• Length: 1207
• Species: Mus musculus
• Alignment Length: 517
• Identity: 118/517 - (22%)
• Similarity: 191/517 - (36%)
• Gaps: 161/517 - (31%)

  Fly    56 LPDGWDIAKDFDGKTYYIDHINKKTTWL------DPRD---CYTKPQTFEDCVGDELPMGWEESY 111
            ||.||:..:|..|::||:||.:|.|||.      |||.   .:.:.:|..:.:| .||.||||..
Mouse   727 LPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPRSKIPAHLRGKTDSNDLG-PLPPGWEERT 790

  Fly   112 DPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY 176
            ..:...::|||..:.||.||||     :|...::..........:.|.|.|    :|.|..|.:.
Mouse   791 HTDGRVFFINHNIKKTQWEDPR-----LQNVAITGPAVPYSRDYKRKYEFF----RRKLKKQTDI 846

  Fly   177 -NHLKLAASRSSLCSSS----SSMSRHDPELLRADLML-------------ARERVHQLKQELTH 223
             |..::...|:::...|    ..:.|.|  ||:|.|.:             |||....:.:|:
Mouse   847 PNKFEMKLRRANILEDSYRRIMGVKRAD--LLKARLWIEFDGEKGLDYGGVAREWFFLISKEM-- 907

  Fly   224 ITNDISYTERGMNTLYSVGE---------KINARENGCYD--------IAEVHAIREEMLKVHKS 271
                       .|..|.:.|         :||.....|.:        |..|..    |...|..
Mouse   908 -----------FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAG----MAVYHGK 957

  Fly   272 LVSGEKVR---EELMRSLVQIKN--ELGRQQISE-----ENS----DLASPFDRVCVASQTDLCG 322
            |:.|..:|   :.:::.|:.:.:  .:..:..|.     ||.    ||....|.       :|.|
Mouse   958 LLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDE-------ELFG 1015

  Fly   323 SSGEN--LNGGARFAEMAKTKWQY----AEWRKHIKKLQQQLADHVERIEPGQLE---SDKDRIL 378
            .:.::  ..||:......|.|.:|    .:|| .:.::|:|:|...|    |..|   .|..:|.
Mouse  1016 QTHQHELKTGGSEIVVTNKNKKEYIYLVIQWR-FVNRIQKQMAAFKE----GFFELIPQDLIKIF 1075

  Fly   379 LIQEKEKLLNDLNSISLKSRSEEEK---------RVIH-----------QTRHKLEE-------- 415
            ...|.|.|:..|..:.:....|..|         :|||           :.|.:|.:
Mouse  1076 DENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRV 1140

  Fly   416 ---DLKEAYEAN-------------------NTCVANRLRF--HEEKQLLLDKLQEALKSTK 453
               ...|.|.:|                   :||. |||..  :|....|.||||.|:::|:
Mouse  1141 PMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCF-NRLDLPPYESFDELWDKLQMAIENTQ 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/35 (43%)
		WW	103..132	CDD:459800	12/28 (43%)
		C2_Kibra	693..813	CDD:176062
Nedd4	NP_001344927.1	C2	<477..530	CDD:472691
		WW	574..602	CDD:238122
		WW	727..756	CDD:459800	14/28 (50%)
		WW	781..813	CDD:197736	15/36 (42%)
		HECTc	874..1203	CDD:214523	73/360 (20%)