DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and magi-1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001255577.1	Gene:	magi-1 / 178107	WormBaseID:	WBGene00010444	Length:	1054	Species:	Caenorhabditis elegans

Alignment Length:	900	Identity:	177/900 - (19%)
Similarity:	283/900 - (31%)	Gaps:	331/900 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYI 120
            ||..|:.|...:|..|:|||....|||.|||               |||.|||:..|.|.|.:|:
Worm   262 LPPNWETAYTENGDKYFIDHNTGTTTWDDPR---------------ELPPGWEQVDDQNYGTFYV 311

  Fly   121 NHLAQSTQLE------------DPRQEWKTV-------QEQMLSDYLSAAQDQLENKREM-FDVK 165
            :|:.:.||.|            |...::.|:       ...:.|.|.|.......:.|:. ||..
Worm   312 DHINRKTQYERPYGFGGSSATIDQPVKYGTLPSSTNHNHNNIYSHYNSGTLKSSSSPRDSGFDSS 376

  Fly   166 QQR---------LLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQEL 221
            ..|         ...:..:|:|.....||     ||:.:...||..|..:|:..:..........
Worm   377 PTRYRKFGDPPETATSSADYDHHSKMFSR-----SSNPLFTTDPARLGGELISTKIVKGAKGLGF 436

  Fly   222 THITNDISYTERG-----MNTLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREE 281
            |.|.||.|  .||     :.::.|.|.   |..||.....::      :::|:..|:.|...:|.
Worm   437 TLIGNDSS--SRGDEFIQVKSVLSGGP---AAANGVLRSGDI------LVRVNGRLLLGATQKEA 490

  Fly   282 LMRSLVQIKNELGRQQISEENSDLASPFDRV------CVASQTDL------CGSSG------ENL 328
            ....:....||....|:.........|.:|:      ..|...||      .||.|      :||
Worm   491 CDVFVAIPVNEAVDIQVCRGYELFIDPANRIVTENVYAAAKSRDLHEIDIFKGSEGFGFTIADNL 555

  Fly   329 NGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSI 393
            ||                  :.|||                       ||...:...|:.....:
Worm   556 NG------------------QRIKK-----------------------ILFPSQCPNLMEGDTIV 579

  Fly   394 SLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEAL--KSTKLLE 456
            .|..|:   .|.|..|:                              |:|.|:|..  ...||:.
Worm   580 ELDGRN---VRPIPHTQ------------------------------LVDMLRERPIGYRGKLVV 611

  Fly   457 ERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFA--VDS--PIDVVDLRRRSQRLF 517
            :|                  ||..|.|...:.:|.  |.:|..  :||  |:.|     ||:.
Worm   612 KR------------------GSPKTRSRTPSAAFR--YGEPQTNMMDSAAPLPV-----RSKT-- 649

  Fly   518 QQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALP 582
                        |..:|....|...:.|::|..:  ||...::...:...| |.:..|:......
Worm   650 ------------PAERQTSRTEEDQNVRNTLQRQ--PAVTSEWEGMSSAIP-ASRMRPSSTTLGF 699

  Fly   583 APPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQK-----------LNMGTPLNLAVAPLS 636
            |.|.|     :|:|....:|.||.:..|        ::|           :...|||::....:.
Worm   700 ATPNY-----IPLSQYNQKPSDLITVSL--------IRKPVGFGFRLLGGVESKTPLSVGQIVIG 751

  Fly   637 PISEKPSLLDLPQEMLS----RSSSTSNTRSV---SAAVSNESV--------------------A 674
            ..:|:...|....|::.    .....|::.:|   .||..|:.|                    |
Worm   752 GAAEEDGRLQEGDEIVEIDGHNVEGASHSEAVVLLEAAAQNKHVKLIVRRPSRTDPARRGSLNSA 816

  Fly   675 GDSGVFEA---------------SRAHLPRKELAQVQ------------IGLKYLKQEGVLVVSL 712
            |.||.::.               |..|.....:.|:|            :|.:.:...|:.::||
Worm   817 GPSGSYDVLLHRNENDGFGFVLMSSQHKNGSTVGQIQPGSPAARCGRLSVGDRVIAVNGIDILSL 881

  Fly   713 ERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQ 777
            ...:.:                 :|:.:|..|:|.             |.|.|.|...:| ..:.
Worm   882 SHPDTI-----------------SLIKDSGLSVRL-------------TIAPPNTAGPVL-PMVS 915

  Fly   778 VTV---VTMTGQKEEIIG--TVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDI 827
            .|:   .||.|..|...|  ....|:.|.:|..|.|            :|:.|.|
Worm   916 ATLGRNFTMNGHYESNYGLPPPPPSVYEKHPPPSYL------------AFDGLSI 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	13/29 (45%)
		WW	103..132	CDD:278809	13/40 (33%)
		C2_Kibra	693..813	CDD:176062	26/136 (19%)
magi-1	NP_001255577.1	NK	180..>244	CDD:302627
		WW	263..293	CDD:238122	14/44 (32%)
		WW	294..323	CDD:278809	13/28 (46%)
		PDZ	421..510	CDD:214570	20/99 (20%)
		PDZ_signaling	535..600	CDD:238492	22/138 (16%)
		PDZ_signaling	717..800	CDD:238492	15/90 (17%)
		PDZ_signaling	822..902	CDD:238492	13/109 (12%)
		PDZ_signaling	968..1049	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000