DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and hecd-1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_001368365.1	Gene:	hecd-1 / 177486	WormBaseID:	WBGene00016405	Length:	2650	Species:	Caenorhabditis elegans

Alignment Length:	1368	Identity:	258/1368 - (18%)
Similarity:	448/1368 - (32%)	Gaps:	448/1368 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 GWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQ--- 167
            |..|..||.:|. ....|....:.|||:     |.|..|..: :|..|:.  .|:|.|..:.
Worm   175 GKMEPTDPELGK-CAESLGALLEHEDPK-----VSESALRCF-AALTDRF--VRKMMDPAELAMH 230

  Fly   168 --------RLLWAQEEYNHLKLAASR---------SSLCSSSSSMSRH---DPEL---LRADLML 209
                    .::.|..:.|....|::.         .:||..||.::..   .|.:   |:|.|..
Worm   231 SNLVEHLISIMVASNDENSPTTASANILSIVLSLIGNLCRGSSLITEKVLTSPNMITGLKATLTN 295

  Fly   210 ARERVHQLKQELTHITNDISYTE---------RGMNTLYSVGEKINARENGCYDIAEVHAIREEM 265
            ..|||         :|:.:.:.:         |....|.||.....|..:|    ||
Worm   296 KEERV---------VTDGLRFCDLLLVLLCEGRSALPLTSVVSGDYAAGSG----AE-------- 339

  Fly   266 LKVHKSLVSGEKVREELMRSLVQIKNELGR------QQISEENSDLASPFDRVCVASQTDLCGSS 324
             :||:.|:  :.:|::.:.:||. ..|.|:      ..:.:..::.||.|..:.:...  || ..
Worm   340 -RVHRQLI--DAIRQKDLTALVD-AIESGQVDVNFADDVGQSLTNWASAFGSIEMVQY--LC-DK 397

  Fly   325 GENLNGGARFAEMAKTKWQYAEWRKH---IKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKL 386
            |.::|.|.:.:.:     .||.....   :|.|.|:.|:...|.|.|:...||.|.....:..::
Worm   398 GSDVNKGHKSSSL-----HYAACFGRPDVVKLLLQRGANPDLRDEDGKTALDKARERSDDDHNQV 457

  Fly   387 LNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALK- 450
            .|.|.|.|...|::|:.:|...|..:.....|.  |..|..:..:: .|:...:..:..|::|.
Worm   458 ANILESPSAFMRNKEDPKVKASTSKQPGTSTKP--ELPNPNLVRKV-LHQLLPIFCEIFQKSLNG 519

  Fly   451 -----STKLLEERLKSFSSESTFSISSGS-----SLGSLSTASSKSALSFTDIYIDPFAVDSPID 505
                 |..|:.:.:::.......::..|:     |...:||..|..|.|...:.:.  .:|...|
Worm   520 SVRRTSLSLMRKIVENIGDLRQSAVGDGNAPAAQSARKMSTDVSAGAESLVAVVVS--VMDQEDD 582

  Fly   506 VVDLRRRSQRLFQQHQQQRLHPVHPVLQQ--QQSAEV---------TLSPRSSLSMETPPASPMK 559
                       .:.|:|..|     :|:.  ::.||:         ......:::.|.|......
Worm   583 -----------HEGHEQVLL-----ILESLLEKDAELWVIELVRLGVFERVEAMAKEPPKGLEEV 631

  Fly   560 YNA----GADQ-TPQAL--KEEPTYANALPAPPAYTA----PPPVPISGVRARPYDLDSTVLDCM 613
            .||    |..: ||..:  :.:|:.:.|:|     ||    ...||.|...|   |.:|.
Worm   632 LNAIHLEGRSRVTPMEIDFENQPSSSTAVP-----TANDIMDTTVPSSSGGA---DAESN----- 683

  Fly   614 MLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSG 678
                       ..|..:.:|  .|.|..||  ...|:.:|:..:|:::.:.||.:...|......
Worm   684 -----------SNPSTIEMA--DPESSTPS--SSTQQSISKPKATASSTASSAILQVVSKLSSVA 733

  Fly   679 VFEASRAHLPRKELAQV-QIGLKYLKQEGVLVVSLERANNLLALWT----------------ASA 726
            ..:.|.|.:.:|....| ..|..|..:|..:|    |....|.:|:                ..|
Worm   734 SLDKSAAAVDKKPTKTVLSQGTPYRWKEWRIV----RGTTSLFIWSDVLLIELPFQSNGWFRYLA 794

  Fly   727 DNS---QVYLRAALLPNSLTSIRTKALGDFQKP--------------VFNDTF-AVPITL----- 768
            ||.   |.....|.:...:|.   :...:|||.              ||:|.: :|||.:
Worm   795 DNDSHVQFVTGTASVDQQMTE---EEKDNFQKTERREMVSRWNAVKGVFDDDWSSVPIAVLGIPS 856

  Fly   769 -DKLLTKSLQVTVVTM------------------TGQKEEIIGTVQI--SMAEFNPEDSTLKWYN 812
             .|.:::.|:|....:                  |||...::.|::|  ....|..|..|.:..|
Worm   857 NAKKVSQKLEVPAWELWSSKSSELQIKSISSSAPTGQANTMLTTIKIQDDAGGFLFETGTGRKTN 921

  Fly   813 VLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPCME 877
            |:....:|                                  ||..|..||. ...||......:
Worm   922 VMPEHALP----------------------------------SDFHTGWSSH-GVSTRKMKFRQD 951

  Fly   878 LQEQMAAEL---LGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFA 939
            :|::...||   |.              :|..:|...|...:.|.|.|::..:.:.::::|.:..
Worm   952 IQKRKVQELAWKLW--------------NDHLKEAHAKPREALVRLENAARTIESTIRHVKAQSN 1002

  Fly   940 DKETNTD-------RAYLPEKSRGQSQLMDDRPVKRSQTFTPS-------------------EAF 978
            .|..|..       :.|....|.....::|||   |..||..|                   ::|
Worm  1003 FKHRNVKQPRIERVQEYCAAISTLHESIVDDR---RLSTFEFSVSGIVPALFGLLSMMEKFPDSF 1064

  Fly   979 SKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIP-RTSLDLEL 1042
            ....:..:.::.::.|.:...:.           ..|..:.|.|:     |....| .:|..|:|
Worm  1065 PSRIFKEQFSKGEALSYLALKIV-----------AVLEANEKFPQ-----HLYDSPGGSSFGLQL 1113

  Fly  1043 DLQAQHSKLYFLNDQIAKLQNLKEVLQKA-----CENKDPLVAAWAIENEEFQRLVARADPAKCP 1102
            ..:...:||..|.....|..|.:.::.|.     ||   ||.:..|| .....|:|.|
Worm  1114 LSRRVRTKLEMLPRADGKENNDENLVNKTGKIVKCE---PLASVGAI-RAYLHRMVTR------- 1167

  Fly  1103 EERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPEL--PSEFTLPEANPI 1165
            :....::...:..|||.:|:                      .||.|: ||  .|:|
Worm  1168 QWHDRERANYRYVKEIQELK----------------------TKGKSI-ELRHVSDF-------- 1201

  Fly  1166 EEEEEEEDENEFYNSAETAIAINTALVASSNRNKNLSEHPHRATSGAVPKIPAPVVTPAATPAAT 1230
                   |||                                   |.:..|           ...
Worm  1202 -------DEN-----------------------------------GVIYWI-----------GTN 1213

  Fly  1231 PAATPAATSAATPAATPVV-SPAAQPDAKPADA------PIPVASNDAEQQRFD-----YVVDRN 1283
            ..|.|..|:.||..|..:. |...||..||.|.      ||...::|.:...|.     :||..:
Worm  1214 GRAAPLWTNPATVKAVKITCSDTRQPFGKPEDLLSRDQNPINCHTSDDKNAHFTIDLGLFVVPTS 1278

  Fly  1284 YGV 1286
            |.:
Worm  1279 YSL 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	7/25 (28%)
		C2_Kibra	693..813	CDD:176062	34/180 (19%)
hecd-1	NP_001368365.1	Ank_2	345..436	CDD:403870	20/101 (20%)
		ANK repeat	345..372	CDD:293786	6/29 (21%)
		ANK repeat	374..403	CDD:293786	6/31 (19%)
		PTZ00322	383..>497	CDD:140343	30/123 (24%)
		ANK repeat	405..436	CDD:293786	6/35 (17%)
		F5_F8_type_C	1243..1365	CDD:419973	9/39 (23%)
		MIB_HERC2	1452..1509	CDD:399589
		HECTc	2221..2648	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900