DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and herc-1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_490834.1	Gene:	herc-1 / 171700	WormBaseID:	WBGene00021685	Length:	1019	Species:	Caenorhabditis elegans

Alignment Length:	393	Identity:	66/393 - (16%)
Similarity:	121/393 - (30%)	Gaps:	167/393 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQL---- 129
            :|:|||.:|   |.:|.:..|....|.:|      |...|..|..:. |:.:|.:|:...:
Worm   586 ETFYIDELN---TSVDLKLEYVLELTRQD------PNKTELDYWTHF-PFLLNGVAKGELIFVEA 640

  Fly   130 ----------------------EDPRQEWKTVQEQMLSDYLSA---------------------A 151
                                  |.|..|....:|.::||.::.                     |
Worm   641 WLMQTLRRQSSLFNTAHGTIIFELPHLELTVRREFIVSDTMNQMAGLSESDLQKPLKVNIAGEDA 705

  Fly   152 QDQLENKREMFDVKQQRLL------WAQEEYNHLK-LAASRSSLCSSSSSMSRHDPELLRADLML 209
            .|....::|.|.:..:::|      ::::|.:||. .:...|..|.
Worm   706 DDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPSEFCD------------------- 751

  Fly   210 ARERVHQL--------------------------------KQELTHITND--------ISYTERG 234
             ||:.|||                                .::|..::..        :||.|..
Worm   752 -REQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDD 815

  Fly   235 MNTLYSVGEKINARENGCYD---IAEVHAIREEMLKVHKSLVSG--EKV-----REELMRSLVQI 289
            :..::.:        |.|..   :.|.|.         ..|:||  ||.     |:|.:|..|..
Worm   816 VEDVFGL--------NFCISFNILGETHT---------TELLSGGTEKPVTNANRDEYVRLYVHH 863

  Fly   290 KNELG------------RQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKW 342
            :.|||            |:..||........|.:.|...:. :.|:...:.|   .|.::...:.
Worm   864 RLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEM-IVGNENYDWN---EFRDILMYRG 924

  Fly   343 QYA 345
            :|:
Worm   925 EYS 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	7/17 (41%)
		WW	103..132	CDD:278809	7/54 (13%)
		C2_Kibra	693..813	CDD:176062
herc-1	NP_490834.1	ATS1	2..359	CDD:227511
herc-1	NP_490834.1	HECTc	667..1016	CDD:238033	48/302 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900