DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and Trip12

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_011236956.1	Gene:	Trip12 / 14897	MGIID:	1309481	Length:	2074	Species:	Mus musculus

Alignment Length:	1082	Identity:	208/1082 - (19%)
Similarity:	340/1082 - (31%)	Gaps:	364/1082 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 RADLMLARERVHQLKQELTHITNDISYTERG------MNTLYSVGEKINARENGCYDIAEVHAIR 262
            |.|..:.....||:.::      :||.:..|      .|::..:.|          |.....||:
Mouse   828 RIDSRIIEVAAHQVGED------EISLSTLGRVYTIDFNSMQQINE----------DTGTARAIQ 876

  Fly   263 EEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSS-GE 326
            .:...:..|..||..          ::|.:..|.|:.:|:.:||..|.:.......::..|| |.
Mouse   877 RKPNPLANSNTSGYS----------ELKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGP 931

  Fly   327 NLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILL--IQEKEKLLND 389
            .:......|.:....:..||..|.:.| ...::.|:    ...|.|...:|::  :|..|.|:..
Mouse   932 AVRHKCLRAILRIIYFADAELLKDVLK-NHAVSSHI----ASMLSSQDLKIVVGALQMAEILMQK 991

  Fly   390 LNSI-SLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTK 453
            |..| |:..|.|   .|:||.:|..|                                    |..
Mouse   992 LPDIFSVYFRRE---GVMHQVKHLAE------------------------------------SES 1017

  Fly   454 LLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQ 518
            ||....|:.::.|       .||||.:.|||.:|.:.|:...|..:
Mouse  1018 LLTSPPKACTNGS-------GSLGSTTPASSGTATAATNASADLGS------------------- 1056

  Fly   519 QHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPA 583
                       |.||..:...:.|||:..||                   ..||.:...... |.
Mouse  1057 -----------PSLQHSRDDSLDLSPQGRLS-------------------DVLKRKRLPKRG-PR 1090

  Fly   584 PPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLL-DL 647
            .|.|:.|              .|...:|                 |.|.:|.:..|.|.|.| .|
Mouse  1091 RPKYSPP--------------RDDDKVD-----------------NQAKSPTTTQSPKSSFLASL 1124

  Fly   648 PQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLK---------YLK 703
            ..:...|.|:.||:.::..|    ..||.||:..|:..........:::..:|         |..
Mouse  1125 NPKTWGRLSAQSNSNNIEPA----RTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFS 1185

  Fly   704 QEGV--------LVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVF-- 758
            .|.:        ::..|..|...|.|.........|.:|:.:..:.::|...:..| |.|.:.
Mouse  1186 SENMDGSNPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSG-FVKQLLLY 1249

  Fly   759 ----NDTFAV--PITLDKLLTKSLQVTVVTMTGQKEEIIGTVQ-------ISMAEFNPEDSTLKW 810
                |:..||  .|.|.:.|.......:     ..||.:|.|:       :::..        |.
Mouse  1250 LTSKNEKDAVGREIRLKRFLHVFFSSPL-----PGEEPVGRVEPVGHAPLLALVH--------KM 1301

  Fly   811 YNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPC 875
            .|.||.......:..|.||.:.|..:.::      |.|     |.......:.|.....:....|
Mouse  1302 NNCLSQMEQFPVKVHDFPSGNGAGGSFSL------NRG-----SQALKFFNTHQLKCQLQRHPDC 1355

  Fly   876 MELQE-------------QMAAE-------LLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGL 920
            ..:::             ..|.|       :...|.:.|.: .|.|||..:||:|:.....   .
Mouse  1356 ANVKQWKGGPVKIDPLALVQAIERYLVVRGIFRYGRVREDD-EDSDDDGSDEEIDESLAAQ---F 1416

  Fly   921 MNSSSMLHA---YL------QNM---------------KQEFADKETN-TDRA----------YL 950
            :||.::.|.   |:      .||               ::|..|.|:| ..||          |.
Mouse  1417 LNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSVQAEDERESTDDESNPLGRAGIWTKTHTIWYK 1481

  Fly   951 PEKSRGQSQLMDDRPVK--------RSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQR 1007
            |.:.       |:...|        |:|| .|::...:       |....|...|.||.|
Mouse  1482 PVRE-------DEESTKDCVGGKRGRAQT-APTKTSPR-------NAKKHDELWHDGVCP----- 1526

  Fly  1008 GAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHS---KLYFLNDQIAKLQNLKEVLQ 1069
            ..|....:......|:::|      ....|||:.|.|:..|:   ..|:|.|...    .||:
Mouse  1527 SVANPLEVYLIPTPPENIT------FEDPSLDVILLLRVLHAISRYWYYLYDNAM----CKEI-- 1579

  Fly  1070 KACENKDPLVAAWAIENEEF--QRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPD 1132
                          |...||  .:|.|:|:       ||||..|:.....| ....|::.|.||.
Mouse  1580 --------------IPTSEFINSKLTAKAN-------RQLQDPLVIMTGNI-PTWLTELGKTCPF 1622

  Fly  1133 LVSFKEK-----ITFFTRKGLSVPELPSEFTLPEANPIEEEE 1169
            ...|..:     :|.|.|.......|.   |.||.|..:.::
Mouse  1623 FFPFDTRQMLFYVTAFDRDRAMQRLLD---TNPEINQSDSQD 1661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	24/151 (16%)
Trip12	XP_011236956.1	SRP1	489..>714	CDD:227396
		WWE	814..876	CDD:397111	11/63 (17%)
		HECTc	1672..2072	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900