DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and PLEKHA7

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:XP_024304124.1 Gene:PLEKHA7 / 144100 HGNCID:27049 Length:1365 Species:Homo sapiens


Alignment Length:1337 Identity:234/1337 - (17%)
Similarity:413/1337 - (30%) Gaps:464/1337 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 LPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYI 120
            ||:.|......||:.::|:...:.||||.||.  .:|......:..:||.||||.:......|:|
Human    11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRT--GEPVNSGHMIRSDLPRGWEEGFTEEGASYFI 73

  Fly   121 NHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASR 185
            :|..|:|....|                ...|...||...:...:....:..|:.........|.
Human    74 DHNQQTTAFRHP----------------VTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSE 122

  Fly   186 SSLCSSSSSM-SRHDPELLRADLMLARERVHQL--KQELTHITNDISYTERG-MNTLYSVGEKI- 245
            :|...::|:: ::..|:::::.     .:||..  :.:......::....|| ::...|.|.:: 
Human   123 TSTAGTASTLEAKPGPKIIKSS-----SKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLW 182

  Fly   246 ----------------NARENG--------CYDIAEVHAIREEMLKVH--KSLVSGEKVREELMR 284
                            ::||..        .|.|:.| |..:.:.:.:  |::.:|       ||
Human   183 KRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPV-APEDRISRKYSFKAVHTG-------MR 239

  Fly   285 SLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRK 349
            :|:...:..|.|   .|.|.:.:.:          ....:.|::|...|....|......:..::
Human   240 ALIYNSSTAGSQ---AEQSGMRTYY----------FSADTQEDMNAWVRAMNQAAQVLSRSSLKR 291

  Fly   350 HIKKLQQQL---ADHVE------RIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRV 405
            .::|:::|.   |:|.|      |:.||.......|     ..:.::|       ..|.|:|...
Human   292 DMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHR-----GHDDIVN-------FERQEQEGEQ 344

  Fly   406 IHQTRHKLE--EDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTF 468
            ....|..||  .|..:|....:..        ||..|.:| |....:..:...:|          
Human   345 YRSQRDPLEGKRDRSKARSPYSPA--------EEDALFMD-LPTGPRGQQAQPQR---------- 390

  Fly   469 SISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQR---LFQ-------QHQQQ 523
                ....|.|..:......:.|..|...|...:     :..:.|||   |.|       |....
Human   391 ----AEKNGMLPASYGPGEQNGTGGYQRAFPPRT-----NPEKHSQRKSNLAQVEHWARAQKGDS 446

  Fly   524 RLHPVHPVLQQQQSAEVTLSPRSSLSM----ETPPASPMKYNAGADQTPQALKEEPTYANALPAP 584
            |..|:...|.:|       .|..|||.    :|.|.|....:.|:...|:.|..:..||.     
Human   447 RSLPLDQTLPRQ-------GPGQSLSFPENYQTLPKSTRHPSGGSSPPPRNLPSDYKYAQ----- 499

  Fly   585 PAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPL---SP----ISEKP 642
               .....:.:|....|.: .|.||......:.: |:...|:|    .||:   ||    .....
Human   500 ---DRASHLKMSSEERRAH-RDGTVWQLYEWQQR-QQFRHGSP----TAPICLGSPEFTDQGRSR 555

  Fly   643 SLLDLPQEMLSRSSSTSNTRSVSAAVSNESV--AGDSGVFEASRAHLPRKELAQVQIGLKYLKQE 705
            |:|::|             ||:|...|...:  .|...||...|.|.|.:     ::.:|...|.
Human   556 SMLEVP-------------RSISVPPSPSDIPPPGPPRVFPPRRPHTPAE-----RVTVKPPDQR 602

  Fly   706 GVLVVSL----ERANNLLALWTASADNSQVYLRAALLPN--------SLTSIRTKALGDFQKPVF 758
            ..:.:||    .||..     .|..::|.|..|:  :|:        |..|:..|:|.:      
Human   603 RSVDISLGDSPRRARG-----HAVKNSSHVDRRS--MPSMGYMTHTVSAPSLHGKSLEE------ 654

  Fly   759 NDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFE 823
                     |..|||:                                                 
Human   655 ---------LSLLLTR------------------------------------------------- 661

  Fly   824 SLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPCMELQEQMAAELLG 888
                                                        |.|:||....::....::|| 
Human   662 --------------------------------------------LRRHQAKLASVRNFAISQLL- 681

  Fly   889 LGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEK 953
            ...|..|.|..||                           .|||..|          |..||..|
Human   682 QHQLTFPTCQADD---------------------------TYLQLKK----------DLEYLDLK 709

  Fly   954 SRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFH 1018
            .:....|::          ...:...|:...||..||.:.             |...:.|||:  
Human   710 IKNNEPLIN----------VLYKVLKKSARGCRPRRSMTG-------------RDLLKDRSLK-- 749

  Fly  1019 SKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWA 1083
                       ...|..:..|::|.:..:..::         ||:|::.::...||||.|.:...
Human   750 -----------PVKIAESDTDVKLSIFCEQDRV---------LQDLEDKIRALKENKDQLESVLE 794

  Fly  1084 IENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGL 1148
            :.:.:.::.  |..|....:....||||.:                  |||..:.::   :|:..
Human   795 VLHRQMEQY--RDQPQHLEKIAYQQKLLQE------------------DLVHIRAEL---SREST 836

  Fly  1149 SVPELPSEFTLPEANPIEEEE---EEEDENEFYNSAETAIA--------INTALVASSNRNKNLS 1202
            .:....:|: |...|.:|:.:   :|:....|:...::.|.        :...|.|:....:.|.
Human   837 EMENAWNEY-LKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILV 900

  Fly  1203 E---HPHRATSGAVPKIPAPVVT-------PAATPAATPAATPAAT------------------- 1238
            |   :|.|.|....|..|.|.::       |..:|..:|..||...                   
Human   901 ESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQL 965

  Fly  1239 -SAATPAATPV-VSPAAQPDAKPADAPIPVASNDAEQ 1273
             ...:|..:|. ..|..|.|..|...|:|...:..:|
Human   966 RKVTSPLQSPTKAKPKVQEDEAPPRPPLPELYSPEDQ 1002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122 10/29 (34%)
WW 103..132 CDD:278809 11/28 (39%)
C2_Kibra 693..813 CDD:176062 19/131 (15%)
PLEKHA7XP_024304124.1 WW 11..40 CDD:306827 10/28 (36%)
WW 56..85 CDD:306827 11/28 (39%)
PH_PEPP1_2_3 159..281 CDD:270068 22/142 (15%)
NESP55 <299..460 CDD:115071 38/207 (18%)
DUF1640 779..905 CDD:311647 26/149 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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