Protein Alignment kibra and HECTD2

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001271203.2
• Gene: HECTD2 / 143279
• HGNCID: 26736
• Length: 780
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 110/607 - (18%)
• Similarity: 201/607 - (33%)
• Gaps: 221/607 - (36%)

  Fly   626 TPLNLAV-APLSPISEKPSLLDLPQEMLSRSSST-----------SNTRSVSAAVSNESVAGDSG 678
            |||.:|. ||.....::.....||..:.:.:.:|           |...|..:|||.:..|.::
Human    12 TPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFSSFISAVSPKKEAAEN- 75

  Fly   679 VFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLT 743
              .:|.|||       |...:|.:::...:.:.:.:...      .|.|.|...::|.:||..:.
Human    76 --RSSPAHL-------VFPNIKNVREPPPICLDVRQKQR------TSMDASSSEMKAPVLPEPIL 125

  Fly   744 SIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTL 808
            .|:.|.:.|||:.|                              |::              .|:.
Human   126 PIQPKTVKDFQEDV------------------------------EKV--------------KSSG 146

  Fly   809 KWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQA 873
            .| ..:...::.:|:|  .|..:||....|.|:.      |..|:|...:...::...||
Human   147 DW-KAVHDFYLTTFDS--FPELNAAFKKDATASF------NTIEDSGINAKFVNAVYDTL----- 197

  Fly   874 PCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEF 938
                              ||.|:              |.|.....|::||          :.:|:
Human   198 ------------------LNTPQ--------------DVQKTVLKGIINS----------LLREW 220

  Fly   939 ADKETNTD-RAYL-----PEKSRGQSQLMDDRPVKRSQTFTPSE-----AFSKNRYNCRLNRSDS 992
            ....|..| |||.     |:.:...:.::....:::..|...::     .:.|.:|: ||::.
Human   221 KGPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKQYS-RLSQK-- 282

  Fly   993 DSAMHCGVAPHTFQRGAAERR----SLRFHSKAPKS---VTK---------------------LH 1029
                       .|:: ..||.    |||.....|:.   :||                     :|
Human   283 -----------RFKQ-LVERLLQFISLRLFPAKPEEFPPITKCSWWIPSAAKVLALLNTANNLVH 335

  Fly  1030 HTHIPRT-----SLDLELDLQAQ-HSKLYFLNDQ---------IAKLQNLKEVLQKACENKDPLV 1079
            ...||.|     :|| .:||..: |:...|.|..         :..:...|.::|:..|.:
Human   336 PPLIPYTDFYNSTLD-HIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQ---- 395

  Fly  1080 AAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKE------ 1138
                :.|...|.||.:....:.|:   :..|.:..     |:|:|.:.....|.::.|.
Human   396 ----MINIARQSLVDKVSRRQRPD---MNILFLNM-----KVRRTHLVSDSLDELTRKRADLKKK 448

  Fly  1139 -KITFFTRKGLSVPELPSEFTL 1159
             |:||....||.:..|..|:.|
Human   449 LKVTFVGEAGLDMGGLTKEWFL 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	17/119 (14%)
HECTD2	NP_001271203.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		8/33 (24%)
		HECTc	421..778	CDD:238033	13/55 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900