Protein Alignment kibra and Magi2

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_063141422.1
• Gene: Magi2 / 113970
• RGDID: 621855
• Length: 1461
• Species: Rattus norvegicus
• Alignment Length: 1448
• Identity: 269/1448 - (18%)
• Similarity: 455/1448 - (31%)
• Gaps: 470/1448 - (32%)

  Fly    11 SQHHLHPHHLRPQQQQQQHHHHHQQQQQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDH 75
            ||.:..|.:.:|:          :.:.|...|...:.:::....||||.|::|....|:.|:|||
  Rat   269 SQPYPAPVYSQPE----------ELKDQMDDTKSTKPEENEDSDPLPDNWEMAYTEKGEVYFIDH 323

  Fly    76 INKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQ 140
            ..|.|:||||| ...|.:..|:|..:|||.|||:..||..|.||::|:.:.||.|:|
  Rat   324 NTKTTSWLDPR-LAKKAKPAEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENP-------- 379

  Fly   141 EQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRA 205
                         .||.||::          .|....|.:|...     ...:...|..|
  Rat   380 -------------VLEAKRKL----------QQHNMPHTELGTK-----PLQAPGFREKP----- 411

  Fly   206 DLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIREEMLKVHK 270
              :..|: ..|||.  |.::..:..:..|.......|::                 .:|.|:|..
  Rat   412 --LFTRD-ASQLKG--TFLSTTLKKSNMGFGFTIIGGDE-----------------PDEFLQVKS 454

  Fly   271 SLVSGEKVREELMRS---LVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENL---- 328
            .:..|...::..|.:   :|.| ||:  ..:...::|:...|..|.:....:|....|..|
  Rat   455 VIPDGPAAQDGKMETGDVIVYI-NEV--CVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDP 516

  Fly   329 ----------------------NGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLE 371
                                  ||          :..|..:.::|.:..|.:.|..:| .|..|.
  Rat   517 EDPANSMVPPLAIMERPPPVMVNG----------RHNYETYLEYISRTSQSVPDITDR-PPHSLH 570

  Fly   372 SDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHE 436
            |......|.......::| :::|:.|....:..::..|       :.:..:.....:|:......
  Rat   571 SMPADGQLDGTYPPPVHD-DNVSVASSGATQAELMTLT-------IVKGAQGFGFTIADSPTGQR 627

  Fly   437 EKQLL----LDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDP 497
            .||:|    ...|.|.....::.::.:::.|......|.....:|     |..|.:.....:..|
  Rat   628 VKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVG-----SETSLIIHRGGFFSP 687

  Fly   498 FAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLS-PRSSLSMETPPASPMKYN 561
            :....|  :||.                      .:.|.|.:.:|| |....|:..|||  :..:
  Rat   688 WKTPKP--MVDR----------------------WENQGSPQTSLSAPAVPQSLPFPPA--LHRS 726

  Fly   562 AGADQT---------PQAL--KEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMML 615
            :..|.|         |..|  |....|.:....||..:              :.:||:..|...|
  Rat   727 SFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTS--------------FRMDSSGPDYKEL 777

  Fly   616 EAKLQKLNMGTPLNL--AVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSG 678
            :..|:::..|....:  ...|..||                        .:.|.::..|...|
  Rat   778 DVHLRRMESGFGFRILGGDEPGQPI------------------------LIGAVIAMGSADRD-- 816

  Fly   679 VFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLT 743
                .|.| |..||..|         :|:.|.. :....::.|...:|.|.||.|
  Rat   817 ----GRLH-PGDELVYV---------DGIPVAG-KTHRYVIDLMHHAARNGQVNL---------- 856

  Fly   744 SIRTKAL-GDFQKPVFNDTFAVPIT-------LDKLLTKSLQVTVVTMTGQKEEIIGTVQISMA- 799
            ::|.|.| |..|:.....:|.:|:|       .|.|::     |.:::.|        :|:..:
  Rat   857 TVRRKVLCGADQRASGGLSFCLPLTQRSTDPRKDCLVS-----TFISVLG--------IQLRSSW 908

  Fly   800 ---EFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTIT 861
               |..||:..             |..|:....:|..:..|..|.||...|.:|  .|..|...:
  Rat   909 LHREPCPENGR-------------SPGSVSTHHSSPRSDYATYANSNHAAPSSN--ASPPEGFAS 958

  Fly   862 SS-QTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECS-------------DDDDDDEEEEL--- 909
            .| |||.:      .:..:|......:.:..||.||..             |....|...:|
  Rat   959 HSLQTSDV------IIHRKENEGFGFVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVG 1017

  Fly   910 -----------------DDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKSRGQ 957
                             |..:|:.|.|       |...|:.:.||..:..|:...:   ||....
  Rat  1018 DRILAVNGQSIINMPHADIVKLIKDAG-------LSVTLRIIPQEELNSPTSAPSS---EKQSPM 1072

  Fly   958 SQ-----LMDDRPVKRSQTFTPSEAFS-------------KNRYNCRLN-RSDSDSAMHCGVAPH 1003
            :|     .....|:.:....||:...:             :|.|...:. |.|        |.|.
  Rat  1073 AQQHSPLAQQHSPLAQPSPATPNSPVAQPAPPQPLQLQGHENSYRSEVKARQD--------VKPD 1129

  Fly  1004 TFQRGAAERRSLRFHSKAP-----KSVTKL-HHTHIPRT-----------------SLDLELDLQ 1045
            ..|....:.|......:.|     ...:.| :..|.|.|                 ::|:|...:
  Rat  1130 IRQPPFTDYRQPPLDYRQPPGGDYSQPSPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAK 1194

  Fly  1046 A----------QHSKLYFL----------------NDQIAKLQNLKEVLQKACENKDPLVAAWAI 1084
            .          ....||.|                .|||.::..         |:...:..|.||
  Rat  1195 GFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEING---------ESTRDMTHARAI 1250

  Fly  1085 E----NEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDL-VSFKEKITFFT 1144
            |    .....||:.:....:.||..:........|          ...|.|:: ||.::.::.|:
  Rat  1251 ELIKSGGRRVRLLLKRGTGQVPEYDEPYAWSAAAA----------AAPGLPEVGVSLEDILSPFS 1305

  Fly  1145 RKGLSVPELPSEFTLPEAN-PIEEEEEEEDENEFYNSAETAIAINTALVASSNRNKNLSEH---- 1204
            ....:.|..||....|:.. .|:.|.:.....|              |.|...:.:.|.|.
  Rat  1306 PSHPAPPSDPSHQIGPDPTWDIQREHDVRKPKE--------------LSAGGQKKQRLGEQRERS 1356

  Fly  1205 --PHRATSGAVPKIPAPVVTPAATPAATPAAT-----------PAATSAATPAATPVVSPAAQPD 1256
              |.|:....:.::|.....|.|...|:.||.           |.|..|....|...|...|:|.
  Rat  1357 ASPQRSARPRLEEVPGGQGRPEAGRPASEAADGKEALRGRREGPGAAGAREAEAKVGVRSGARPA 1421

  Fly  1257 AKP---------ADAPIP 1265
            |:|         |.||.|
  Rat  1422 ARPTGGGLARKAAVAPGP 1439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/29 (52%)
		WW	103..132	CDD:459800	14/28 (50%)
		C2_Kibra	693..813	CDD:176062	25/131 (19%)
Magi2	XP_063141422.1	None