Protein Alignment kibra and WWP2

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001257383.1
• Gene: WWP2 / 11060
• HGNCID: 16804
• Length: 870
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 96/511 - (18%)
• Similarity: 177/511 - (34%)
• Gaps: 162/511 - (31%)

  Fly     5 QQTASQSQHHLHPHHLRPQ--QQQQQHHHHHQQQQQQQHTHHQQQQQHHSD-------------- 53
            ::|..:.:.:...|:.|..  |:....:..:.:|.|.|....|...||.|.
Human   338 KRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD 402

  Fly    54 --FPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIG 116
              .|||.||:..:| :|:.||::|..:.|.|.|||   |:....|..    ||.|||..|.....
Human   403 PLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPR---TQGMIQEPA----LPPGWEMKYTSEGV 459

  Fly   117 PYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY----- 176
            .|:::|..::|..:|||..:::..:|              .....:|   :...|...::
Human   460 RYFVDHNTRTTTFKDPRPGFESGTKQ--------------GSPGAYD---RSFRWKYHQFRFLCH 507

  Fly   177 -----NHLKLAASRSSLCSSS----SSMSRHDPELLRADLM-------------LARERVHQLKQ 219
                 :|:|::.||.:|...|    .:|..:|   ||..|.             :|||....|..
Human   508 SNALPSHVKISVSRQTLFEDSFQQIMNMKPYD---LRRRLYIIMRGEEGLDYGGIAREWFFLLSH 569

  Fly   220 ELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIREEMLK--------VHKSLVSGE 276
            |:             :|.:|.:.| ...:.|.|..|....:|..:.|.        :..:|..|:
Human   570 EV-------------LNPMYCLFE-YAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK 620

  Fly   277 KVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTK 341
            .:                       ::....||.:..:..:..|
Human   621 FI-----------------------DTGFTLPFYKRMLNKRPTL--------------------- 641

  Fly   342 WQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSE------ 400
                   |.::.:..:..:.:..|:...||.....:..||:.| :|..:.:..||...|
Human   642 -------KDLESIDPEFYNSIVWIKENNLEECGLELYFIQDME-ILGKVTTHELKEGGESIRVTE 698

  Fly   401 --EEKRVIHQTRHKLEEDLKEAYEA-----NNTCVANRLRFHEEK--QLLLDKLQE 447
              :|:.::..|..:....::|..:|     |.......||:.:||  :|:|..:||
Human   699 ENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQE 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	12/29 (41%)
		WW	103..132	CDD:278809	9/28 (32%)
		C2_Kibra	693..813	CDD:176062
WWP2	NP_001257383.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..299
		Atrophin-1	<164..343	CDD:331285	1/4 (25%)
		WW	302..331	CDD:306827
		WW	332..361	CDD:306827	4/22 (18%)
		WW	407..435	CDD:306827	11/28 (39%)
		WW	447..477	CDD:238122	10/29 (34%)
		HECTc	516..868	CDD:238033	52/308 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900