DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kibra and WWP1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_008944.1	Gene:	WWP1 / 11059	HGNCID:	17004	Length:	922	Species:	Homo sapiens

Alignment Length:	466	Identity:	96/466 - (20%)
Similarity:	161/466 - (34%)	Gaps:	127/466 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RPQQQQQQHHHHHQQQQQQQHTHHQQQQQHH----------SD--FPLPDGWDIAKDFDGKTYYI 73
            ||..:..::....|.|:.|.....||..|.:          :|  .|||.||:...|...:.|::
Human   411 RPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFV 475

  Fly    74 DHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKT 138
            :|..|.|.|.|||     .|..::  .:.||.|||..|......|:::|..::|..:|||....:
Human   476 NHNTKTTQWEDPR-----TQGLQN--EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSS 533

  Fly   139 VQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY--------NHLKLAASRSSLCSSS-SS 194
            |         :....|:..:|..      |...|...|        :|:|:..||.:|...| ..
Human   534 V---------TKGGPQIAYERGF------RWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQ 583

  Fly   195 MSRHDPELLRADLM-------------LARERVHQLKQELTHITNDISYTERGMNTLYSVGEKIN 246
            :....|..||..|.             ||||....|..|:             :|.:|.:.| ..
Human   584 IMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEV-------------LNPMYCLFE-YA 634

  Fly   247 ARENGCYDIAEVHAIREE--------------------------MLKVHKSLVSG-------EKV 278
            .:.|.|..|.....|..:                          .|..:|.::|.       |.:
Human   635 GKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESI 699

  Fly   279 REELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQ 343
            ..|...||:.|::    ..|.|...::....|...:...|     |.:...||:......:.|.:
Human   700 DTEFYNSLIWIRD----NNIEECGLEMYFSVDMEILGKVT-----SHDLKLGGSNILVTEENKDE 755

  Fly   344 Y----AEWR--KHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEE 402
            |    .|||  :.:::..:...|....:.|.|.....|.    :|.|.:|..:..:.|   ::.:
Human   756 YIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDE----KELEVMLCGMQEVDL---ADWQ 813

  Fly   403 KRVI--HQTRH 411
            :..:  |.||:
Human   814 RNTVYRHYTRN 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	11/29 (38%)
		WW	103..132	CDD:278809	9/28 (32%)
		C2_Kibra	693..813	CDD:176062
WWP1	NP_008944.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..388
		HUL4	<307..922	CDD:227354	96/466 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900