DRSC/TRiP Functional Genomics Resources

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Protein Alignment kibra and Wwp1

DIOPT Version :10

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_796301.2 Gene:Wwp1 / 107568 MGIID:1861728 Length:918 Species:Mus musculus


Alignment Length:466 Identity:97/466 - (20%)
Similarity:161/466 - (34%) Gaps:127/466 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RPQQQQQQHHHHHQQQQQQQHTHHQQQQQHH----------SD--FPLPDGWDIAKDFDGKTYYI 73
            ||..:..::....|.|:.|.....||..|.:          :|  .|||.||:...|...:.|::
Mouse   407 RPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFV 471

  Fly    74 DHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKT 138
            :|..|.|.|.|||   |:....|    :.||.|||..|......|:::|..::|..:|||....:
Mouse   472 NHNTKTTQWEDPR---TQGLPNE----EPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSS 529

  Fly   139 VQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEY--------NHLKLAASRSSLCSSS-SS 194
            |         :....|:..:|..      |...|...|        :|:|:..||.:|...| ..
Mouse   530 V---------TKGGPQIAYERSF------RWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQ 579

  Fly   195 MSRHDPELLRADLM-------------LARERVHQLKQELTHITNDISYTERGMNTLYSVGEKIN 246
            :....|..||..|.             ||||....|..|:             :|.:|.:.| ..
Mouse   580 IMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEV-------------LNPMYCLFE-YA 630

  Fly   247 ARENGCYDIAEVHAIREE--------------------------MLKVHKSLVSG-------EKV 278
            .:.|.|..|.....|..:                          .|..:|.::|.       |.:
Mouse   631 GKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESI 695

  Fly   279 REELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQ 343
            ..|...||:.|::    ..|.|...::....|...:...|     |.:...||:......:.|.:
Mouse   696 DTEFYNSLIWIRD----NNIEECGLEMYFSVDMEILGKVT-----SHDLKLGGSNILVTEENKDE 751

  Fly   344 Y----AEWR--KHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEE 402
            |    .|||  :.:::..:...|....:.|.|.....|.    :|.|.:|..:..:.|   ::.:
Mouse   752 YIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDE----KELEVMLCGMQEVDL---ADWQ 809

  Fly   403 KRVI--HQTRH 411
            :..:  |.||:
Mouse   810 RNTVYRHYTRN 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122 11/29 (38%)
WW 103..132 CDD:459800 9/28 (32%)
C2_Kibra 693..813 CDD:176062
Wwp1NP_796301.2 C2_E3_ubiquitin_ligase 17..140 CDD:175988
DUF5585 <148..>381 CDD:465521
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..182
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..360
Required for interaction with and ubiquitination of AMOTL2. Required for interaction with YAP1. /evidence=ECO:0000250|UniProtKB:Q9H0M0 345..527 37/126 (29%)
Interaction with ERBB4. /evidence=ECO:0000269|PubMed:19561640 345..525 36/124 (29%)
WW 347..376 CDD:459800
HUL4 <377..918 CDD:227354 97/466 (21%)
Blue background indicates that the domain is not in the aligned region.

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