DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and YAP1

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_005271435.1	Gene:	YAP1 / 10413	HGNCID:	16262	Length:	510	Species:	Homo sapiens

Alignment Length:	369	Identity:	92/369 - (24%)
Similarity:	145/369 - (39%)	Gaps:	113/369 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCY---------TKP--- 92
            ||. .|...:...|.|||.||::||...|:.|:::||::.|||.|||...         |.|
Human   158 QHL-RQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221

  Fly    93 QTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQE--WKTVQEQMLSDYLSAAQ--- 152
            |...:.....||.|||::...:...|||||..::|...|||.:  :.....|.:|......|
Human   222 QNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFGKAMNQRISQSAPVKQPPP 286

  Fly   153 ------------------------DQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSS 193
                                    .||:.::|...:|||.||      ..::..|.|:  .:.|:
Human   287 LAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELL------RQVRPQAMRN--INPST 343

  Fly   194 SMSRHDPEL-LRADL-MLARERVHQ-------LKQELTHITNDIS--------------YTERGM 235
            :.|....|| ||:.| .|.::...|       :.|||..:|.:.|              .|:.|:
Human   344 ANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGL 408

  Fly   236 N-TLYSV----------------GEKIN-----ARENGCYDIAEVHAIREEMLKVHKSLVSGEKV 278
            : :.|||                |:.||     :::|...|..|  ||  ....|....:.|:.:
Human   409 SMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLE--AI--PGTNVDLGTLEGDGM 469

  Fly   279 R---EELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTD 319
            .   ||||.||        ::.:|   ||:.:..:.|..|::.|
Human   470 NIEGEELMPSL--------QEALS---SDILNDMESVLAATKLD 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	14/29 (48%)
		WW	103..132	CDD:278809	11/28 (39%)
		C2_Kibra	693..813	CDD:176062
YAP1	XP_005271435.1	WW	174..203	CDD:238122	13/28 (46%)
YAP1	XP_005271435.1	WW	232..261	CDD:366073	11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900