Protein Alignment kibra and HUWE1

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_016884680.1
• Gene: HUWE1 / 10075
• HGNCID: 30892
• Length: 4501
• Species: Homo sapiens
• Alignment Length: 1402
• Identity: 265/1402 - (18%)
• Similarity: 458/1402 - (32%)
• Gaps: 426/1402 - (30%)

  Fly    96 EDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLE----------DPRQEWKTVQEQMLS---DY 147
            ||.:.||.|                ::|:|::.|:          ||..|.:..||:..|   :.
Human  2506 EDVLMDEAP----------------SNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNED 2554

  Fly   148 LSAAQDQLENKREMFDVKQQ---------------RLLWAQEEYNHLK---------------LA 182
            ...:||:.|.:.|..:..|:               ..:...|:|..:.               |.
Human  2555 EDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPDMNASPLVRFERFDREDDLI 2619

  Fly   183 ASRSSLCSSSSSMSRHDPELLRADLMLARERVHQ-----LKQELTHITNDISYTERGMNTL-YSV 241
            ....::.||::.:......:.....::.|...|.     .....|.:|..|..::|.:..| .:.
Human  2620 IEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANT 2684

  Fly   242 GEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNEL-----GRQQISEE 301
            |..|:....|             ..:.:..|:....:.......::|:.:.|     ||.::...
Human  2685 GHTIHVHYPG-------------NRQPNPPLILQRLLGPSAAADILQLSSSLPLQSRGRARLLVG 2736

  Fly   302 NSDLASPFDRVCVASQTDLCG------SSGENLNGGARFAEMAKTKW-------QYAEWRKHIKK 353
            |.|:     .:...|..:|..      |:..:..|.......|.|:|       ........:..
Human  2737 NDDV-----HIIARSDDELLDDFFHDQSTATSQAGTLSSIPTALTRWTEECKVLDAESMHDCVSV 2796

  Fly   354 LQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLK 418
            ::..:.:|:|.:...:||..:       ||.:          |..:|||.::    ..|.:|| |
Human  2797 VKVSIVNHLEFLRDEELEERR-------EKRR----------KQLAEEETKI----TDKGKED-K 2839

  Fly   419 EAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTAS 483
            |..:.:..|.|:                   ||....|:.| |..:....|..:..|....:|:.
Human  2840 ENRDQSAQCTAS-------------------KSNDSTEQNL-SDGTPMPDSYPTTPSSTDAATSE 2884

  Fly   484 SKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVL----QQQQS--AEVTL 542
            ||..|.                          ..|..|||...|..|.|    |:.||  .|...
Human  2885 SKETLG--------------------------TLQSSQQQPTLPTPPALGEVPQELQSPAGEGGS 2923

  Fly   543 SPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPA----PPAYTAPPPVPISGVRARPY 603
            |.:..:.:|.....|.:.:..|:.|...|...||..:..|.    ..|.||..    |.:...|.
Human  2924 STQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVS----SQLEGSPM 2984

  Fly   604 DLDSTVLDCMMLEA----------KLQKLNMGTPLNL--AVAPLSPISEKPSLLDLPQEMLS--R 654
            | .|::..|.:.||          :..:....||.:.  |||.:...|:.......|.|..|  .
Human  2985 D-TSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPA 3048

  Fly   655 SSSTSNTRSVSAAVS-------------------NESVAGDS---GVFEASRAHLP---RKELAQ 694
            ||.:|:||..:.|:|                   .:.:||.|   ||..:..|.||   |:|:.|
Human  3049 SSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQ 3113

  Fly   695 VQIGLK---------------YLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTS 744
            .|:|::               .:...||..||.|                   ..|||.|    :
Human  3114 NQLGIRPPTRTAPSTNSSAPAVVGNPGVTEVSPE-------------------FLAALPP----A 3155

  Fly   745 IRTKALG---------DFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAE 800
            |:.:.|.         :..:...:||...|:|..:.|...|:.:|  :...::.::..:...:|
Human  3156 IQEEVLAQQRAEQQRRELAQNASSDTPMDPVTFIQTLPSDLRRSV--LEDMEDSVLAVMPPDIA- 3217

  Fly   801 FNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREE------------ 853
              .|...|:.......:.:.........||||.:|.....|..:...||...:
Human  3218 --AEAQALRREQEARQRQLMHERLFGHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTF 3280

  Fly   854 ----SSDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQL 914
                ||..:..:.|...||.|.:...: |..:..:.||.|..::||:.
Human  3281 QMGGSSSHNRPSGSNVDTLLRLRGRLL-LDHEALSCLLVLLFVDEPKL----------------- 3327

  Fly   915 VSDVGLMNSSSMLHAYLQNM-----------------KQEFADKE---------TNTDRAYLPEK 953
                    ::|.||..|:|:                 .|..::.|         |:.::.....|
Human  3328 --------NTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCIETPKLTTSEEKGKKSSK 3384

  Fly   954 SRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHC----------GVAPHTFQRG 1008
            |.|.|. .::||:   ......|:.|.|:.:. |:.| .|:|:.|          |...|| ::.
Human  3385 SCGSSS-HENRPL---DLLHKMESKSSNQLSW-LSVS-MDAALGCRTNIFQIQRSGGRKHT-EKH 3442

  Fly  1009 AAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLY--FLNDQIAKLQNL---KEVL 1068
            |:...::..|.:|...|.:    |:        ||...|.:|::  ....|..|..|.   :|..
Human  3443 ASGGSTVHIHPQAAPVVCR----HV--------LDTLIQLAKVFPSHFTQQRTKETNCESDRERG 3495

  Fly  1069 QKACENKDPLVAAWAIENEEFQRLV--------------ARADPAKCPEERQLQKLLMKTAKEIH 1119
            .|||.......::..|..:.:..||              .::.|.....|.:.....::.:
Human  3496 NKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGETSPYSLEAS---- 3556

  Fly  1120 KLRKTKVPKG-CPDLVSFK--EKITFFTRKGLSVPELPSEFTLPEANPIEEEEEEEDENEFYNSA 1181
                   |.| ..:::|..  .:.:..|.|.|.:..|.| ..||| |.:.|.:.        ||.
Human  3557 -------PLGQLMNMLSHPVIRRSSLLTEKLLRLLSLIS-IALPE-NKVSEAQA--------NSG 3604

  Fly  1182 ETAIAINTALVASSNRNKNLSEHPHRATSGAVPKIPAPVVTPAATPAATPAAT---PAATSAATP 1243
            ..|.:..||...:|......:     :|:...|..|.||.:..|..|||..:|   .|:|:..||
Human  3605 SGASSTTTATSTTSTTTTTAA-----STTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTP 3664

  Fly  1244 -AATPVVSPAAQPDAKPADAPIPVASNDAEQQRFDYV 1279
             .||..||  ..|..|.:.:|..|:...:....|..|
Human  3665 TTATTTVS--ISPTTKGSKSPAKVSDGGSSSTDFKMV 3699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	4/38 (11%)
		C2_Kibra	693..813	CDD:176062	24/143 (17%)
HUWE1	XP_016884680.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900