DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kibra and hecw2a

DIOPT Version :9

Sequence 1:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	XP_009302976.1	Gene:	hecw2a / 100150269	ZFINID:	ZDB-GENE-090311-22	Length:	1475	Species:	Danio rerio

Alignment Length:	481	Identity:	91/481 - (18%)
Similarity:	165/481 - (34%)	Gaps:	162/481 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDEL 103
            :|..|..|:    .|.|||..|:...|..|:.:::||:|:.|||..|             .|...
Zfish   712 RQDIHRYQR----VDEPLPPNWEARIDSHGRIFFVDHVNRTTTWQRP-------------TGPPA 759

  Fly   104 PMGWEESYD-----------PNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDY---------- 147
            |.|...|..           .:|.....:..::..::|||..:...|..|.:|:|
Zfish   760 PQGLTRSSSILQMEQLNRRYQSIRRTMTSERSEEPRVEDPPADETDVLAQSISEYRRDGIIGQSS 824

  Fly   148 ----------------LSA---------------------------------AQ--DQLENKRE- 160
                            ||:                                 ||  ::.::.|:
Zfish   825 SRSRLALLLQSPGAKFLSSPDFFSVLHSNPSAYRMFTSNTCLKHMISKVRRDAQHFERYQHNRDL 889

  Fly   161 -----MFDVKQQRLL--WAQEEYNHLKLAASRSSLCSSSSSMSRHDPEL----LRADLMLARERV 214
                 :|..||..|.  | :.:::|...|......|.:::.:   ||.|    .|:..:|| .|.
Zfish   890 VNFLNLFSNKQLELPRGW-EMKHDHTGKAFFVDHNCRATTFI---DPRLPLQNSRSSGLLA-HRQ 949

  Fly   215 HQLKQELTHITNDISYTER----------GMNTLY------SVGEKINA--RENGCYDIAEVHAI 261
            | |.::.:|...::....|          ..|:.|      :..:||.|  |:...::|.:..
Zfish   950 H-LSRQRSHSAGEVGDDSRSPSPPVQGRSSRNSQYQDLVPVAYNDKIVAFLRQPNIFEILQER-- 1011

  Fly   262 REEMLKVHKSLVSGEKVREELMRSLVQ-IKNELGRQQISEENSD-----LASPFDRVCVA----- 315
                        ..|.||...:|..|| |:|| |...::..:||     |.|.|:...::
Zfish  1012 ------------QPELVRNHSLREKVQFIRNE-GATGLTRLSSDADLVMLLSLFEEEVMSYVPPN 1063

  Fly   316 --SQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRIL 378
              ..:..|.:|.::..|..|....|...::        :..:.:|.:...::|.........::.
Zfish  1064 ALLLSSYCHASPQSSPGTPRANARAPAPYK--------RDFEAKLRNFYRKMETKGYGQGPGKVK 1120

  Fly   379 LIQEKEKLLND-LNSISLKSRSEEEK 403
            ||..::.||.| .|.|...||.:.::
Zfish  1121 LIIRRDHLLEDAFNQIMCYSRKDLQR 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	11/29 (38%)
		WW	103..132	CDD:278809	5/39 (13%)
		C2_Kibra	693..813	CDD:176062
hecw2a	XP_009302976.1	HECW_N	50..169	CDD:318711
		C2_NEDL1-like	188..323	CDD:176073
		WW	724..756	CDD:197736	13/44 (30%)
		WW	903..934	CDD:197736	7/34 (21%)
		HECTc	1120..1473	CDD:238033	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900