Protein Alignment kibra and herc5.4

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_005160166.1
• Gene: herc5.4 / 100148091
• ZFINID: ZDB-GENE-090311-7
• Length: 995
• Species: Danio rerio
• Alignment Length: 569
• Identity: 121/569 - (21%)
• Similarity: 189/569 - (33%)
• Gaps: 182/569 - (31%)

  Fly   275 GEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQT-DLCGSSGENLNGGARFAEMA 338
            |.:|||..  .||:      .:|:...|..:     :.|.:|.. |:  |:|::..|..|
Zfish     6 GAQVREGF--GLVK------PEQVRHGNWGI-----KFCPSSAVQDI--SAGKSCIGFIR----- 50

  Fly   339 KTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDR---------ILLIQEKEKLLNDLNSIS 394
                   |.:..:.:|..:.||  |::||.||::::.|         :||..:.:.|:.|.:::.
Zfish    51 -------EGKVSVLRLHNEDAD--EKLEPLQLQNERIRSIVCGEAGAVLLADDGKVLIMDQSTVC 106

  Fly   395 LKSRSEEEKRVIH-----QTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKL 454
            ...:|.|.::||.     |....|..|.:......||          ..||.|.|.|...:|.:.
Zfish   107 RPLKSLENRQVIQIACGDQHSMALSNDGQLFVWGENT----------HGQLGLRKEQAGTQSPQH 161

  Fly   455 LEER------------------------------------------------LKSFSSESTFSIS 471
            |:..                                                :||...:.|.|||
Zfish   162 LQSLCEIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTKDRFVPTIVKSLCGKKTVSIS 226

  Fly   472 SGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQ- 535
            .|   |..:...||....||      |....   ...|...|  |..:|        ||.|..:
Zfish   227 CG---GEHTATLSKGGTVFT------FGSGG---FGQLGHNS--LKDEH--------HPRLIAEL 269

  Fly   536 ---QSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISG 597
               :.::||.....:|..|  .:|.:.|:.|.....|....|....:.           |:|:
Zfish   270 WGSKVSQVTCGRHHTLVFE--ESSKLIYSFGCGMQGQLGNGEQVKQSV-----------PLPV-- 319

  Fly   598 VRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSP--ISEKP------SLLDLPQEMLSR 654
                       :|.....|..::||..|...:.|:...:|  .||||      .:|.|...|:.|
Zfish   320 -----------LLPTECTEFTMEKLITGEHHSFALFFKNPGNESEKPKSGSNGGILTLNDRMIDR 373

  Fly   655 SSSTS----------NTRSVSAAVSNESVAGDS--GVFEASRAH------LPRKELAQVQIGLKY 701
            ..|.|          ||...|||..|.|....|  ..::.|..|      |.:...|:: ...|.
Zfish   374 WVSESDPWPTVKNEINTVFSSAASLNGSFLKTSRDEHYQTSVEHCGLDFDLVKTSFAKL-FASKS 437

  Fly   702 LKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKAL 750
            |..|.|.||......:|....| ..:..::||....|.|.|...|||.:
Zfish   438 LISEVVKVVQQTLLPSLNPNPT-GVEALRLYLLLPELINGLKKQRTKLI 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	17/58 (29%)
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274	7/38 (18%)
		RCC1	133..183	CDD:278826	10/59 (17%)
		RCC1	186..235	CDD:278826	8/51 (16%)
		RCC1	239..286	CDD:278826	12/65 (18%)
		RCC1	294..343	CDD:278826	11/72 (15%)
		HECTc	658..993	CDD:294058
		HECTc	682..992	CDD:214523

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900