Protein Alignment kibra and wwc3

DIOPT Version :10

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: XP_002932841.2
• Gene: wwc3 / 100127609
• XenbaseID: XB-GENE-5928407
• Length: 1196
• Species: Xenopus tropicalis
• Alignment Length: 1271
• Identity: 378/1271 - (29%)
• Similarity: 607/1271 - (47%)
• Gaps: 222/1271 - (17%)

  Fly    21 RPQQQQQQHHHHHQQQQQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDP 85
            |.||||||......:||:.........::..|:.|||.||:.|:|:||:.:||||..::|:|:||
 Frog    11 RRQQQQQQQPQAPSEQQRCPSPGPSSCRRGSSELPLPAGWEEARDYDGRVFYIDHNTRQTSWIDP 75

  Fly    86 RDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSA 150
            ||..|||.||.||||:|||:|||...|..||.||::|:.|.||:||||::|:..||:||.:||..
 Frog    76 RDRITKPLTFADCVGNELPLGWEIVRDQQIGVYYMDHINQLTQVEDPREQWRREQERMLKEYLVV 140

  Fly   151 AQDQLENKREMFDVKQQRLLWAQEEYNHLKLAA---SRSSLCSSS--SSMSRHDPELLRADLMLA 210
            ||:.|..|:|::.:||||...||||:..|....   |||.:.|.|  |:.:::||..::|::...
 Frog   141 AQEALNAKKEIYQIKQQRFELAQEEFQQLHDLCEDDSRSYVSSFSGFSANTKYDPYQIKAEIANR 205

  Fly   211 RERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSG 275
            |:|:.:||:|||.:..::.|.|:|:.||..:..|:::.... |.:.|..||..|:..:.:::..|
 Frog   206 RDRLSRLKRELTVMKQELQYKEKGVETLQEIDRKMSSAHTN-YKLDEAQAIMSELRTLRQAICMG 269

  Fly   276 EKVREELMRSLVQIKNEL-----------GRQQISEENSDLASPFDRVCVASQTDLCGSSGENLN 329
            ||.|.:||:||.::.:..           |.|..|...:|...|.......||||..|..|  .:
 Frog   270 EKERRDLMQSLAKLTDGFRNSCCISDSLYGAQHNSGSLTDSCLPQQYCDACSQTDNIGEFG--FD 332

  Fly   330 GGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSIS 394
            ..:|.|:..:..|||.|.:|.:..:|.|||.......|...|:|:|.:.||:|||.||.||..|.
 Frog   333 DKSRLADRVRLNWQYEEAKKRVSSIQHQLALLDNETWPVMAEADRDHLQLIKEKEALLQDLQLIC 397

  Fly   395 LKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERL 459
            .:.||.|:...:.:...:|.::::.|:..:...:..||...|::..||..|:||.:....|..::
 Frog   398 QQRRSPEDLSRMEEEMRRLSDEIQRAHATSAQGITERLLLQEKRNSLLRCLEEATRLASYLHTQI 462

  Fly   460 KSFSSESTFSISSGSSLGSL-----STASSK---SALSFTDIYIDPFAVDSPIDVVDLRRRSQRL 516
            ||.|: ||.::|||||.|||     |.|||:   |::||||||..|.           ..:::..
 Frog   463 KSLSA-STLTVSSGSSRGSLASSRGSLASSRGSLSSISFTDIYGLPH-----------YEKAETQ 515

  Fly   517 FQQHQQQRLHPVH----------------PVLQQQQ------SAEVTLSPRSSLSMETPPASPMK 559
            .:..||.|...:.                |.|.:|:      .:..:||.|||||..:||:||:.
 Frog   516 VEYGQQMRFDMIPLDALSKDCQYSETGGLPNLNKQKISMDTPQSLASLSSRSSLSSLSPPSSPLD 580

  Fly   560 ---YNAGAD----QTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDL-----DSTVLDC 612
               .:|..|    |..:.|:|..:..:               :..:|.....|     ..|....
 Frog   581 TPFLSASCDSPLTQMSEGLEEIMSIGS---------------LDMIRGNSLTLGEENNQGTSSQT 630

  Fly   613 MMLEAKLQKLNMGTPL--NLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTR-----SVSAAVSN 670
            .....:.:..|:..||  .|.::..|||.|                 ...||     .|||.:|:
 Frog   631 QGYNTENKGKNLSGPLLSRLQMSAASPIQE-----------------VCTTRLQGACRVSAGLSD 678

  Fly   671 ESVAGDSGVFEASR-----------AHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTA 724
            :|:..||||||...           .:..:.|..||.:|:.|..:...|:|.:.:..||...:
 Frog   679 DSLTSDSGVFETLNKRNGNVDDSVLKNSAKNEEPQVHVGIVYDSESECLLVHVLQLKNLSCAF-- 741

  Fly   725 SADNSQVYLRAAL--LPNSLTSIR-TKALGDFQKP-VFNDTFAVPITLDKLLTKSLQVTVVTMTG 785
            .....::::|..|  |.:|..|.. :||| :|..| :||:.|.:|:....|...|||:.:.::..
 Frog   742 FKQGCKIHIRVYLPSLDSSTPSTYCSKAL-EFHMPLMFNEIFQIPMHASILKQSSLQLYICSVCP 805

  Fly   786 Q-KEEIIGTVQISMAEFNPEDST---LKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPN 846
            | :|:::|..||.:|::  |.||   |:||.      |..:.|.|....|        ...::..
 Frog   806 QLQEKLLGIAQIGLADY--EGSTEMHLQWYP------IQMYSSTDPQKVS--------EIEDSMQ 854

  Fly   847 PGNNREESSDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDD 911
            |..|..|     |.|.:.:..|.|..|....::.::|.|.:.|....|.....:..:|:.|.:.:
 Frog   855 PAENVTE-----TKTDAVSILLARTTAQLEAVERELAVERVKLEYTEEEILEMERKEDQTEAISE 914

  Fly   912 K-------------------------------QLVSDVGLMNSSSMLHAYLQNMKQEFADKETNT 945
            :                               |..:..|..|....:..:.:.:|   .||||||
 Frog   915 RSWQAESVDSGCHSNYNQLSPHYSEGCYGDAVQGSAQTGQANLYDPVKTHNEPIK---VDKETNT 976

  Fly   946 DRAY------LPE-----KSRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCG 999
            :..:      ||:     :||| |..:....:.|||||:|.   ::::|.|||.||||||:....
 Frog   977 EDVFPDEVTNLPKERTCHRSRG-SPFVRSSTIVRSQTFSPG---ARSQYVCRLYRSDSDSSTLPR 1037

  Fly  1000 VAPHTFQRGAAERRSLRFHSKA-PKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQN 1063
            .:|  |.|...|||:||:..:: ..|:.::    :.||||||||||||..::...||::|..|:.
 Frog  1038 KSP--FIRNTLERRTLRYKQQSCQSSMAEI----MARTSLDLELDLQASRTRQRQLNEEINALRE 1096

  Fly  1064 LKEVLQKACENKDPLVAAWAIENEEFQRLVARAD------PAKCPEERQLQKLLMKTAKEIHKLR 1122
            ||..|::........:..|.:.:|.|:.|:..|:      ..:..:|:..:|:|.|.:|||..||
 Frog  1097 LKHRLEEVQLRGQSDLPQWVLRDERFRSLLLEAERQTRQTKLEHHQEQAAEKMLKKASKEIFHLR 1161

  Fly  1123 --KTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSE 1156
              ..|.|.   .:.:|:|||.||||..:::|.||::
 Frog  1162 GQNQKEPF---QVQTFREKIAFFTRPRINIPPLPAD 1194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	15/29 (52%)
		WW	103..132	CDD:459800	15/28 (54%)
		C2_Kibra	693..813	CDD:176062	38/127 (30%)
wwc3	XP_002932841.2	WW	46..75	CDD:459800	14/28 (50%)
		WW	93..122	CDD:459800	15/28 (54%)
		EnvC	181..>489	CDD:443969	96/311 (31%)
		DR0291	197..>285	CDD:441187	27/88 (31%)
		C2_Kibra	712..833	CDD:176062	36/125 (29%)