Protein Alignment kibra and wwc1

DIOPT Version :9

• Sequence 1: NP_001034055.1
• Gene: kibra / 41783
• FlyBaseID: FBgn0262127
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_001096212.1
• Gene: wwc1 / 100124763
• XenbaseID: XB-GENE-985007
• Length: 1108
• Species: Xenopus tropicalis
• Alignment Length: 1214
• Identity: 380/1214 - (31%)
• Similarity: 609/1214 - (50%)
• Gaps: 222/1214 - (18%)

  Fly    53 DFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGP 117
            :.|||:||:.|:|.|||.|||||.:|.|:|:||||.:|||.||.||:|||||:|||||||..:|.
 Frog     5 ELPLPEGWEEARDVDGKVYYIDHTSKTTSWIDPRDRFTKPLTFADCIGDELPLGWEESYDTQVGV 69

  Fly   118 YYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLK-- 180
            |||:|.:|:||:||||.:|:..||:||.|||..||:.|..::|::.||||||..||:||..|.
 Frog    70 YYIDHNSQTTQIEDPRVQWRREQERMLKDYLVLAQEALLAQKEIYQVKQQRLELAQKEYRTLNDV 134

  Fly   181 ---LAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVG 242
               ...|::||.|.|||.|::||::|:|::...:.||::||:|:..:..::.|.|.|..||..:.
 Frog   135 WKHKVGSQTSLVSGSSSSSKYDPDILKAEIATTKSRVNKLKREMVFLRQELQYKENGYQTLKEID 199

  Fly   243 EKINARENGC-YDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKN----ELGRQ-QISEE 301
            .|::  :|.| |.:.|..||..||..:.|::.|||:.:::|::||.::||    :.|.| .:...
 Frog   200 LKMS--KNHCAYKLDEAQAILNEMKTIKKAITSGEREKQDLIQSLAELKNGFLVDKGSQSDLWAS 262

  Fly   302 NSDLASPFDRVC-----VASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADH 361
            |:.|||..:.:.     |:||||:.|:.....|.  ..||..:.:.:|.|.::.|..::.|||..
 Frog   263 NTSLASSANSLSRQYLNVSSQTDISGNLSVVSNN--HLAEKVRLQLRYEEAKRRIANIKIQLAKI 325

  Fly   362 VERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNT 426
            .....||.|:|::||::||.|||:||.::..||.:..|:.|...:...:.:|||||:.|.:..:.
 Frog   326 DSDAWPGVLDSERDRLILISEKEELLKEMRFISPRKWSQSEVERLESEKKQLEEDLQAARDTQSK 390

  Fly   427 CVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSL---------STA 482
            .:..||:...::..|:.:|:|..:....|:.:||..|: |..|:|||||.|||         |:.
 Frog   391 ALTERLKMSSKRNQLVKELEETTRLIASLQAQLKCLST-SMQSLSSGSSPGSLASSRGSLVTSSQ 454

  Fly   483 SSKSALSFTDIYIDPF-AVDSPIDVVDLRRRSQRLFQQ--------------HQ-----QQRLHP 527
            .|.::.|.:|:|.:.. .:||     :.:.:...|.|:              |:     .|:..|
 Frog   455 DSSTSASVSDLYYEQLDHLDS-----EYQNKVDFLIQEGAMGYRPSGCITTIHENEVVRSQKTDP 514

  Fly   528 VHPV-----LQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAY 587
            .:.|     |.....:..:||||||||..:||.||                       |...|..
 Frog   515 ANRVKALRSLSGTPKSMTSLSPRSSLSSPSPPCSP-----------------------LVTDPLL 556

  Fly   588 TAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMG---TPLNLAVAPLS---PISEKPSLLD 646
            |                     :|..:.:...:.:::.   |.||:.....|   ...|:||
 Frog   557 T---------------------VDAFLSQIDFEDIDLPLSFTELNVNAGGDSYQHETDEEPS--- 597

  Fly   647 LPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHL------------PRKELAQVQIGL 699
             .|.:.....|:.:...||||||:|||.|||||:||:....            ...:.|:::||:
 Frog   598 -GQGLSCLGVSSLSVAGVSAAVSDESVTGDSGVYEATNQRTLMENAVFDGEDSEMMDTAKIKIGM 661

  Fly   700 KYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTS---IRTKALGDFQKPVFNDT 761
            ||.::.....|.:.:.:||.||  ....|.::|:|.|:||.|.::   .||:.|......::|:.
 Frog   662 KYDEKNKHFAVFVIQLDNLAAL--LLHQNEKLYIRVAVLPCSESTSCLFRTRTLEQSDTLLYNEM 724

  Fly   762 FAVPITLDKLLTKSLQVTVVT-MTGQKEEIIGTVQISMAEF-NPEDSTLKWYNVLSSKFIPSFES 824
            |.|..:...|..|:|:|.|.| .:...||.:|..|||:|:. :.|:....|||:||.:::
 Frog   725 FLVSTSHSALRQKTLRVDVCTRQSNHHEECLGGSQISLADVCHSEEQEAHWYNLLSYRYL----- 784

  Fly   825 LDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPCMELQEQMAAEL--- 886
                                     .|:..:.:..|:..:.|.: .|......|.:|.||||
 Frog   785 -------------------------KRQSKTSKQKISCCEESGI-ENPDSVSALLKQTAAELEAV 823

  Fly   887 ---LG--------LGPLNEPECSDDD---DDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQE 937
               :|        :.|..:....|:|   :::.|||.|     .||......|.:.|...:...:
 Frog   824 RKQIGESTDPPEYIWPEKKDNVPDEDGISENEGEEEFD-----GDVQCETEESDMQAATDSASVK 883

  Fly   938 FADKETNTD------RAYLPEKSRG----QSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDS 992
             .||||||:      .:..|:..|.    |:..:....:.||:||:|.   .:::|.||||||||
 Frog   884 -VDKETNTEGLAMSLSSVRPKDKRAATPMQAPFIRGNTIIRSKTFSPG---PQSQYICRLNRSDS 944

  Fly   993 DSAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQ 1057
            :|:......|  |.|.|.||||:|.  |.| ||.......:.||||||||||||..:..:.|..:
 Frog   945 ESSTLSKKPP--FVRNAMERRSVRV--KRP-SVKSTGSERLIRTSLDLELDLQASRTWHHQLTQE 1004

  Fly  1058 IAKLQNLKEVLQKA---CENKDPLVAAWAIENEEFQRLVARADPAKCPE-----ERQLQKLLMKT 1114
            |:.|:.|||.|::|   .||:.|    ..::::|..:::.|....:..:     |.|..|::...
 Frog  1005 ISVLRELKEQLEQAKRLGENELP----QRVKDDETFKVMLRQVEKQVQKIEQKYEMQADKMMRAA 1065

  Fly  1115 AKEIHKLR--KTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSE 1156
            ||::|:||  .:|.|.   ::.||:||:.||||..:::|.|.::
 Frog  1066 AKDVHRLRGQSSKEPL---EVQSFREKMAFFTRPRMNLPTLTAD 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kibra	NP_001034055.1	WW	57..87	CDD:238122	18/29 (62%)
		WW	103..132	CDD:278809	18/28 (64%)
		C2_Kibra	693..813	CDD:176062	39/124 (31%)
wwc1	NP_001096212.1	WW	7..39	CDD:197736	20/31 (65%)
		WW	55..84	CDD:278809	18/28 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..456		9/21 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..547		10/23 (43%)
		C2_Kibra	655..778	CDD:176062	39/124 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	828..861		7/32 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2362
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1326
OMA	1	1.010	-	-		QHG50236
OrthoDB	1	1.010	-	-		D181722at33208
OrthoFinder	1	1.000	-	-		FOG0003726
OrthoInspector	1	1.000	-	-		otm49020
Panther	1	1.100	-	-	O	PTHR14791
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4620
SonicParanoid	1	1.000	-	-		X1418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110