DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kibra and herc3

DIOPT Version :9

Sequence 1:NP_001034055.1 Gene:kibra / 41783 FlyBaseID:FBgn0262127 Length:1288 Species:Drosophila melanogaster
Sequence 2:NP_001139096.1 Gene:herc3 / 100003587 ZFINID:ZDB-GENE-090313-139 Length:1046 Species:Danio rerio


Alignment Length:375 Identity:70/375 - (18%)
Similarity:135/375 - (36%) Gaps:102/375 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 PYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLEN------KREMF------------- 162
            |:.:.|:.::..:.|..:|.....:..|...|....|..|.      .:|.|             
Zfish   697 PFLVLHVRRNHLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYG 761

  Fly   163 ---DVKQQRLLWAQE----EYNHLKLAASRSSLCS----SSSSMSRHDPELLRADLMLARERVHQ 216
               ...:..|||..:    |:|...|.   ..:|.    :|:.:..|.|.:|...|:.....:..
Zfish   762 MFTQYSESNLLWFSDKCFVEHNWFHLI---GIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLDD 823

  Fly   217 LKQELTHITNDISYTE-RGMNTLYSVGEKINARENGCYDIA---EVHAIRE--EMLKVHKSLVSG 275
            ||        ::|.|| |.:..|...  :.:..|..|.:.|   |.:.|.|  |:::..|::...
Zfish   824 LK--------ELSPTEGRSLQQLLEF--EGDVEETFCLNFAITREYYGITEVKELVQGGKTIAVD 878

  Fly   276 EKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENL------------ 328
            :..|:|.:::.:|.   :....:.|:.|..:|.|.:||          .||.|            
Zfish   879 KTNRKEFVQAYLQY---VFSDAVQEQYSAFSSGFLKVC----------GGEILSLFQPSELMAMV 930

  Fly   329 --NGGARFAEMAKT---KWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKL-L 387
              |....:.||.|.   |.:::.....:|...:...:.       .||..|..:|.:...::: :
Zfish   931 VGNNNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEF-------SLEKKKQFLLFLTGSDRIPI 988

  Fly   388 NDLNS--ISLKSRSEEEKRV-------------IHQTRHKLEEDLKEAYE 422
            :.:.|  |.::|.:.||..:             .:||:..|.:.|.:|.|
Zfish   989 HGMASLRIVIQSTAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLTQAVE 1038

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kibraNP_001034055.1 WW 57..87 CDD:238122
WW 103..132 CDD:278809 2/14 (14%)
C2_Kibra 693..813 CDD:176062
herc3NP_001139096.1 RCC1 4..49 CDD:278826
RCC1_2 37..65 CDD:290274
RCC1 52..99 CDD:278826
RCC1 103..152 CDD:278826
RCC1 155..205 CDD:278826
RCC1 208..257 CDD:278826
RCC1 260..308 CDD:278826
RCC1 314..374 CDD:278826
HECTc 699..1044 CDD:238033 69/373 (18%)
HECTc 723..1043 CDD:214523 66/349 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.