DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hexim and Hexim2

DIOPT Version :9

Sequence 1:	NP_731932.1	Gene:	Hexim / 41778	FlyBaseID:	FBgn0038251	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001123987.1	Gene:	Hexim2 / 71059	MGIID:	1918309	Length:	313	Species:	Mus musculus

Alignment Length:	235	Identity:	66/235 - (28%)
Similarity:	101/235 - (42%)	Gaps:	51/235 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GSAEKESGSQQRPLDSG---GGGGAS----GGGGVAVGGGS---GMPKRKHRRGKKSKMQPKKTK 68
            ||....||.:.:..|.|   .|.|:|    |....:.||.|   .:.::||||      :|.|.|
Mouse    40 GSQLLPSGQEIQSEDEGTVPAGDGSSCNIRGSRTQSPGGCSVEAVLARKKHRR------RPSKRK 98

  Fly    69 NHYPQWKLDMSTGAGATLEGNQRQNSRTKLVRSRSL-----LVPYNTNRFLM------EEHMSEL 122
            .|   |:..:........:.::||:.|...||....     |.||||.:|||      |.::..|
Mouse    99 RH---WRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPLAPYNTTQFLMNDRDLEEPNLDVL 160

  Fly   123 H------------KDDSDDNCFGSQTEDQVLFLSKEFSDVYERARLERLETMSKQELIQECMQIE 175
            |            ..|||     .|......|..::||:.|||...|.|:..|||||:::.:.:|
Mouse   161 HGPSHSGSGGENEAGDSD-----GQGRAHGEFQQRDFSEAYERYHTESLQGRSKQELVRDYLDLE 220

  Fly   176 DRYSKAQNISKEF----GAKLRAQDDKIRQLSRENQFLRT 211
            .|.|:|:..::..    |...|....::.:|:.|.:.|||
Mouse   221 RRLSQAEQETRRLRQLQGCSSRQPCQQVEELAAEVERLRT 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hexim	NP_731932.1	HEXIM	<107..178	CDD:291959	28/88 (32%)
Hexim2	NP_001123987.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78		10/37 (27%)
		HEXIM	101..226	CDD:373740	37/129 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..139		6/27 (22%)
		Interaction with P-TEFb. /evidence=ECO:0000250	139..142		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..194		8/43 (19%)
		Interaction with CCNT1, HEXIM1 and HEXIM2. /evidence=ECO:0000250	225..286		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..313
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836946
Domainoid	1	1.000	52	1.000	Domainoid score	I11405
eggNOG	1	0.900	-	-		E1_2CHCC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	72	1.000	Inparanoid score	I5285
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005824
OrthoInspector	1	1.000	-	-		otm44248
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13469
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5413
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.880