| Sequence 1: | NP_731932.1 | Gene: | Hexim / 41778 | FlyBaseID: | FBgn0038251 | Length: | 360 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001020307.1 | Gene: | Hexim1 / 498008 | RGDID: | 1559851 | Length: | 356 | Species: | Rattus norvegicus |
| Alignment Length: | 330 | Identity: | 84/330 - (25%) |
|---|---|---|---|
| Similarity: | 118/330 - (35%) | Gaps: | 145/330 - (43%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 3 EAVKNGKNRHSGSAEKESGSQQRPLDSGGGG---------------------GASGGGG--VAVG 44
Fly 45 GGS----GMP------------------------------------KRKHRRGKKSKMQPKKTKN 69
Fly 70 HY-PQWKLDMSTGAGATLEG----NQRQNSRTKLVRSRSL-----LVPYNTNRFLMEEHMSE--- 121
Fly 122 -----------LHKDDSDDNCF---------------GSQTEDQVLFLSKEFSDVYERARLERLE 160
Fly 161 TMSKQELIQECMQI-------EDRYSKAQNISKEFGA-------------KLRAQDDKIRQLSRE 205
Fly 206 NQFLR 210 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Hexim | NP_731932.1 | HEXIM | <107..178 | CDD:291959 | 34/106 (32%) |
| Hexim1 | NP_001020307.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..160 | 28/129 (22%) | |
| Basic region, mediates nuclear localization and interaction with 7SK snRNA and NR3C1. /evidence=ECO:0000250 | 147..174 | 14/40 (35%) | |||
| HEXIM | 163..295 | CDD:291959 | 41/143 (29%) | ||
| Interaction with P-TEFb. /evidence=ECO:0000250 | 199..202 | 2/2 (100%) | |||
| Autoinhibitory acidic region, in absence of 7SK snRNA interacts with the basic region preventing interaction with P-TEFb and modulating subcellular localization. /evidence=ECO:0000250 | 207..247 | 7/39 (18%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 209..259 | 8/53 (15%) | |||
| Mediates interaction with CCNT1. /evidence=ECO:0000250 | 283..311 | 7/27 (26%) | |||
| Required for inhibition of ESR1-dependent transcription. /evidence=ECO:0000250 | 307..352 | 12/41 (29%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 337..356 | 3/8 (38%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C166340665 | |
| Domainoid | 1 | 1.000 | 52 | 1.000 | Domainoid score | I11172 |
| eggNOG | 1 | 0.900 | - | - | E1_2CHCC | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 65 | 1.000 | Inparanoid score | I5263 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 1 | 1.000 | - | - | FOG0005824 | |
| OrthoInspector | 1 | 1.000 | - | - | otm46346 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_109694 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR13469 |
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 10 | 9.750 | |||||