Protein Alignment Hexim and HEXIM2

DIOPT Version :10

• Sequence 1: NP_731932.1
• Gene: Hexim / 41778
• FlyBaseID: FBgn0038251
• Length: 360
• Species: Drosophila melanogaster
• Sequence 2: XP_011522610.4
• Gene: HEXIM2 / 124790
• HGNCID: 28591
• Length: 447
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 75/288 - (26%)
• Similarity: 113/288 - (39%)
• Gaps: 99/288 - (34%)

  Fly     1 MAEAVKNGKNRHSGSAEKES------GSQQRP---LDSGGG----------------GGASGGGG 40
            ||...:...|..|..|.:|:      ||.|.|   .||||.                .||.||.|
Human   163 MATPNQTACNAESPVALEEAKTSGAPGSPQTPPERHDSGGSLPLTPRMESHSEDEDLAGAVGGLG 227

  Fly    41 --------VAVGGGSG---MPKRKHRRGKKSKMQPKKTKNHYPQWKLDMSTGAGATLEGNQRQNS 94
                    .:.||.|.   :.::||||      :|.|.|.|   |:..:........:.::||:.
Human   228 WNSRSPRTQSPGGCSAEAVLARKKHRR------RPSKRKRH---WRPYLELSWAEKQQRDERQSQ 283

  Fly    95 RTKLVRSRSL-----LVPYNTNRFLMEEHMSELHKDDSDDNCF--------GSQTEDQV------ 140
            |...||....     :.||||.:|||.:      :|..:.|..        ||..|.:.
Human   284 RASRVREEMFAKGQPVAPYNTTQFLMND------RDPEEPNLDVPHGISHPGSSGESEAGDSDGR 342

  Fly   141 -----LFLSKEFSDVYERARLERLETMSKQELIQECMQIEDRYSKAQNISK-------------- 186
                 .|..|:||:.|||...|.|:..|||||:::.:::|.|.|:|:..::
Human   343 GRAHGEFQRKDFSETYERFHTESLQGRSKQELVRDYLELEKRLSQAEEETRRLQQLQACTGQQSC 407

  Fly   187 ----EFGA---KLRAQDDKIRQLSRENQ 207
                |..|   :||.::.::||   |||
Human   408 RQVEELAAEVQRLRTENQRLRQ---ENQ 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hexim	NP_731932.1	HEXIM	90..181	CDD:464638	34/114 (30%)
HEXIM2	XP_011522610.4	HEXIM	263..388	CDD:464638	35/130 (27%)
		ZapB	380..437	CDD:442308	13/56 (23%)