| Sequence 1: | NP_731932.1 | Gene: | Hexim / 41778 | FlyBaseID: | FBgn0038251 | Length: | 360 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_006451.1 | Gene: | HEXIM1 / 10614 | HGNCID: | 24953 | Length: | 359 | Species: | Homo sapiens |
| Alignment Length: | 252 | Identity: | 71/252 - (28%) |
|---|---|---|---|
| Similarity: | 108/252 - (42%) | Gaps: | 76/252 - (30%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 2 AEAVKNGKNRHSGSAEKESGSQQRPLDSGGGGGASGGGGVAVGGGSGMPKRKHRRGKKSKMQPKK 66
Fly 67 TKNHY-PQWKLDMSTGAGATLEG----NQRQNSRTKLVRSRSL-----LVPYNTNRFLMEEHMSE 121
Fly 122 --------------LHKDDSDDNCF---GSQTE--------DQVLFLSKEFSDVYERARLERLET 161
Fly 162 MSKQELIQECMQIEDRYSKAQNISKEF---GAKLRAQDDKIRQLSRENQFLRTHLLR 215 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Hexim | NP_731932.1 | HEXIM | <107..178 | CDD:291959 | 33/95 (35%) |
| HEXIM1 | NP_006451.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..163 | 20/67 (30%) | |
| Basic region, mediates nuclear localization and interaction with 7SK snRNA and NR3C1. /evidence=ECO:0000269|PubMed:15941832 | 150..177 | 14/40 (35%) | |||
| HEXIM | 200..298 | CDD:317686 | 33/97 (34%) | ||
| Interaction with P-TEFb | 202..205 | 2/2 (100%) | |||
| Autoinhibitory acidic region, in absence of 7SK snRNA interacts with the basic region preventing interaction with P-TEFb and modulating subcellular localization | 210..250 | 8/39 (21%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 213..262 | 8/48 (17%) | |||
| SH3_and_anchor | <283..351 | CDD:275056 | 17/56 (30%) | ||
| Mediates interaction with CCNT1 | 286..314 | 6/27 (22%) | |||
| Required for inhibition of ESR1-dependent transcription | 310..355 | 8/29 (28%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165147004 | |
| Domainoid | 1 | 1.000 | 53 | 1.000 | Domainoid score | I11372 |
| eggNOG | 1 | 0.900 | - | - | E1_2CHCC | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 73 | 1.000 | Inparanoid score | I5296 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S8077 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 1 | 1.000 | - | - | FOG0005824 | |
| OrthoInspector | 1 | 1.000 | - | - | otm42197 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_109694 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR13469 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R6090 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 12 | 11.730 | |||||