Protein Alignment CG3505 and HPN

DIOPT Version :10

• Sequence 1: NP_650380.2
• Gene: CG3505 / 41777
• FlyBaseID: FBgn0038250
• Length: 360
• Species: Drosophila melanogaster
• Sequence 2: NP_002142.1
• Gene: HPN / 3249
• HGNCID: 5155
• Length: 417
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 85/312 - (27%)
• Similarity: 131/312 - (41%)
• Gaps: 71/312 - (22%)

  Fly    78 VQVC-CPSTAGLGALTHPLLPSDCGKVRW---QRSNDTDTRIREFPWLALIEYTRGNQEKIHACG 138
            :.|| ||....|.|:.     .|||:.:.   :.....||.:..:||...:.|     :..|.||
Human   135 ISVCDCPRGRFLAAIC-----QDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRY-----DGAHLCG 189

  Fly   139 GVLISDRYVLTAAHCVAQAATSNLQITAVRLGEWDTSTNPDCQYHEDSKVADCAPPYQDIAIEEL 203
            |.|:|..:|||||||..:....        |..|....         ..||..:|....:.::.:
Human   190 GSLLSGDWVLTAAHCFPERNRV--------LSRWRVFA---------GAVAQASPHGLQLGVQAV 237

  Fly   204 LPH----PLYNRTDRTQINDIALVRLASPAKLNDFVQPICLP--NKQLRADELEDLVTEVAGW-- 260
            :.|    |..:.......||||||.|:||..|.:::||:|||  .:.|    ::..:..|.||
Human   238 VYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQAL----VDGKICTVTGWGN 298

  Fly   261 ------QASSSQRMRKGYVTISSIEECQRK--YASQQLRIQASKLC------GLTNSQECYGNAG 311
                  ||...|..|   |.|.|.:.|...  |.:|   |:....|      |:   ..|.|::|
Human   299 TQYYGQQAGVLQEAR---VPIISNDVCNGADFYGNQ---IKPKMFCAGYPEGGI---DACQGDSG 354

  Fly   312 GPLM----LFKNDGYLLGGLVSFGPVPCPNPDWPDVYTRVASYIDWIHDSLK 359
            ||.:    :.:...:.|.|:||:| ..|.....|.|||:|:.:.:||..::|
Human   355 GPFVCEDSISRTPRWRLCGIVSWG-TGCALAQKPGVYTKVSDFREWIFQAIK 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3505	NP_650380.2	CLIP	32..82	CDD:463440	2/4 (50%)
		Tryp_SPc	111..356	CDD:238113	75/270 (28%)
HPN	NP_002142.1	Hepsin-SRCR	51..159	CDD:462736	9/28 (32%)
		Tryp_SPc	163..400	CDD:238113	73/272 (27%)