DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3505 and F10

DIOPT Version :9

Sequence 1:	NP_650380.2	Gene:	CG3505 / 41777	FlyBaseID:	FBgn0038250	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	400	Identity:	102/400 - (25%)
Similarity:	150/400 - (37%)	Gaps:	112/400 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GRVTGHCI---SIRECDYFMRILLSGNLSQSDRNLLRDNQCGVRGNDVQVCCP---STAGLGALT 92
            |..|..|:   ..:.|:.|.|.|.|  |...|    .|..|....|.|...|.   :.|..|...
Human   106 GEYTCTCLEGFEGKNCELFTRKLCS--LDNGD----CDQFCHEEQNSVVCSCARGYTLADNGKAC 164

  Fly    93 HPLLPSDCGK-----------------------VRW-------------------------QRSN 109
            .|..|..|||                       :.|                         :|.:
Human   165 IPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGD 229

  Fly   110 DTDTRI--------REFPWLALIEYTRGNQEKIHACGGVLISDRYVLTAAHCVAQAATSNLQITA 166
            :..|||        .|.||.||:.    |:|....|||.::|:.|:||||||:.||....
Human   230 NNLTRIVGGQECKDGECPWQALLI----NEENEGFCGGTILSEFYILTAAHCLYQAKRFK----- 285

  Fly   167 VRLGEWDTSTNPDCQ-YHEDSKVADCAPPYQDIAIEELLPHPLYNR-TDRTQINDIALVRLASPA 229
            ||:|:.:|......: .||               :|.::.|   || |..|...|||::||.:|.
Human   286 VRVGDRNTEQEEGGEAVHE---------------VEVVIKH---NRFTKETYDFDIAVLRLKTPI 332

  Fly   230 KLNDFVQPICLPNKQLRADELED-LVTEVAGWQASSSQRMRKG-------YVTISSIEECQRKYA 286
            .....|.|.|||.:    |..|. |:|:..|..:...:...||       .:.:..::....|.:
Human   333 TFRMNVAPACLPER----DWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLS 393

  Fly   287 SQQLRIQASKLCGLTNSQE--CYGNAGGPLMLFKNDGYLLGGLVSFGPVPCPNPDWPDVYTRVAS 349
            |..:..|.....|....||  |.|::|||.:....|.|.:.|:||:|. .|.......:||:|.:
Human   394 SSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGE-GCARKGKYGIYTKVTA 457

  Fly   350 YIDWIHDSLK 359
            ::.||..|:|
Human   458 FLKWIDRSMK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3505	NP_650380.2	CLIP	30..82	CDD:288855	14/50 (28%)
		Tryp_SPc	111..356	CDD:238113	76/264 (29%)
		Tryp_SPc	111..354	CDD:214473	74/262 (28%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011	3/15 (20%)
		FXa_inhibition	129..164	CDD:317114	10/40 (25%)
		O-glycosylated at one site	183..203		1/19 (5%)
		Tryp_SPc	235..464	CDD:238113	74/260 (28%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920