DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)L1231 and INO80D

DIOPT Version :9

Sequence 1:	NP_001247104.1	Gene:	l(3)L1231 / 41776	FlyBaseID:	FBgn0086686	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	XP_011509671.1	Gene:	INO80D / 54891	HGNCID:	25997	Length:	1056	Species:	Homo sapiens

Alignment Length:	1050	Identity:	233/1050 - (22%)
Similarity:	360/1050 - (34%)	Gaps:	303/1050 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 TSPASLPSPTLPPATAAVTAMVAP-----ISVSPKGG-LPL--------PPSKFHHTTLAQHLQK 298
            |...||..|||        |:..|     :|:||.|. :||        .|..|:...  ..|:|
Human   137 TMAFSLTVPTL--------ALKMPNGLDGMSLSPPGARVPLHYLETELEDPFAFNEED--DDLKK 191

  Fly   299 VECLKKKKSLPLACQNNNNNSNLPNNNNVESLKKPVVQGTSYNQTH--PPPLMVFNTGTVAVPAQ 361
            ...::||....||       .|.......|.||        ..|.|  |||         |...|
Human   192 GATVRKKLQSKLA-------QNRQRQRETEILK--------VRQEHFSPPP---------APSQQ 232

  Fly   362 SPQTAAPQKHSTGNSVDDSDLNEIPVNVIFRKP-QEAGGAAKTGGPGGLSAPVSGTPQTRPAEVK 425
            .|    ||:||          :..|::...:.| ...|...|:..|...|.|:.|
Human   233 QP----PQQHS----------HLSPLSTSLKPPAPPQGSVCKSPQPQNTSLPMQG---------- 273

  Fly   426 MVTPLTPPTPPEMSAPPLLAQMQP-PQIPTSCVPALAPSFKVSSPAVLSPKVISPAPA-SPKLLC 488
                 ..||...::....|:..:| |.:|:|..|.:.|.        .:.:::..|.| ||...|
Human   274 -----VAPTTHTIAQARQLSHKRPLPLLPSSRAPTVDPP--------RTDRILMKATAFSPHFSC 325

  Fly   489 PTAPASTNSLQIAPKAVPATTTSSAPALATKSEQMSSKV-ANLNAFNRQAPIASKGVRNGITNNN 552
                  .:.||...|            |.|:..|:.:.: .:|                |:..:.
Human   326 ------ISRLQRLVK------------LCTQKHQLDTDLFPHL----------------GLDWSE 356

  Fly   553 NNRNSNVVAKKSSPTSMPPPKDPIAPIAANELTDSEHRQRRRKPASACRRSLDTLSENESFSVDS 617
            .:......::::||..:           |..:.::...||        ..|.|..:|:.|..| :
Human   357 ESGEEPEDSEQASPYQV-----------AWSIRETLRYQR--------HASDDDDAESRSSRV-T 401

  Fly   618 PYC--LQQHWLHSGFNNKSHDAPLSQSNRREDRIAVRKGALRRQALQLLST------RSLQELPM 674
            ..|  .||.:.|           |.:..|.|.|....:...|:..||..|.      :.:||| .
Human   402 QLCTYFQQKYKH-----------LCRLERAESRQKKCRHTFRKALLQAASKEPECTGQLIQEL-R 454

  Fly   675 RAAKQRLQCVQNMLIKYQDHA--GQQQGIGIGNHCLVASCKQPTLSMAAHCERHIVNNSTQQLFQ 737
            |||..|....:..|.:.:..|  |..:|         ..|....|....||.:||:.|.:||||.
Human   455 RAACSRTSISRTKLREVEPAACSGTVKG---------EQCANKALPFTRHCFQHILLNHSQQLFS 510

  Fly   738 PCVAWRMDGTACQAPVFDVLHTLALCKVH-----SHLRSGMDGARPASKQPPVSLPVAGVATLYV 797
            .|.|...||..|..||||:.|...||:.|     :.||.  |.:|....|
Human   511 SCTAKFADGQQCSVPVFDITHQTPLCEEHAKKMDNFLRG--DNSRKVQHQ--------------- 558

  Fly   798 PVKQQRKRKANTNAVARPQKRGRKPANEPIANQISSQINKLIPGA---GMQRKSSTTSLESIASN 859
               ||||.:..|...|..:|..:|....|...|      |.||.|   |.....::.||...||:
Human   559 ---QQRKPRKKTKPPALTKKHKKKRRRGPRRPQ------KPIPPAVPQGNLSMPASVSLPVEASH 614

  Fly   860 SQSSAT---SHSQPPYKPGNVLAAVPAAQNLSQRSIPPALAPLSSDFQ--PNHQQQEPLLVPKLE 919
            .:|.:|   |..:.|....|.:..:|....|:|......|..|..|.|  ...:.:...|:|..|
Human   615 IRSPSTPELSADELPDDIANEITDIPHDLELNQEDFSDVLPRLPDDLQDFDFFEGKNGDLLPTTE 679

  Fly   920 VDSLFKFDADQQQNQQQQSTLDPSLLSLDIANIKAEEISQIVAQLAAAG----------GDLQNP 974
                   :|::.:...|..|   ||..|....:.|:.....|.:|:..|          ..:|:.
Human   680 -------EAEELERALQAVT---SLECLSTIGVLAQSDGVPVQELSDRGIGVFSTGTGASGIQSL 734

  Fly   975 NNNNNNNIG-------IHNN-NSVHFNNNNNNSMNYSNNNNNSFPSFNTAFGNAMGQ---PSNTI 1028
            :...|.::|       :|:| :|:..:.|...|...||      |....| |...||   |:|.
Human   735 SREVNTDLGELLNGRIVHDNFSSLELDENLLRSATLSN------PPTPLA-GQIQGQFSAPANV- 791

  Fly  1029 THNGHAVPAVLANTADLLGQDMF-----GICENSSAYASSEDTGLGGLSESELIGT------NDA 1082
               |.....:::.:|  ||:..|     |:.:.|.|........|  ||:::.:.|      :|.
Human   792 ---GLTSATLISQSA--LGERAFPGQFHGLHDGSHASQRPHPAQL--LSKADDLITSRQQYSSDH 849

  Fly  1083 DDIALNGAHLLEEH------DLVNVFDTLSDDAFNELFQSVQQAECEAM-DRALDRALQQTMGG- 1139
            ...:.:|:|...||      |.:....|.|....|  ..:...||...| ...|...|:..:||
Human   850 SHSSPHGSHYDSEHVPSPYSDHITSPHTTSYSGDN--MAATFSAEMPIMAQHLLPTQLEVPLGGV 912

  Fly  1140 -------------SADSAFLNDFLDVGDDLLADAVMHSPNTSGID-APPLFGDSSSGGGNSSSNG 1190
                         ..|.:..::.|.....||:.::...|.||..: ..|.|       ...:.:.
Human   913 VNPRTHWGNLPVNLGDPSPFSNLLGADGHLLSTSLSTPPTTSNSETTQPAF-------ATVTPSS 970

  Fly  1191 ASDIRGLVQT 1200
            :|.:.||.||
Human   971 SSVLPGLPQT 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)L1231	NP_001247104.1	zf-C3Hc3H	712..767	CDD:290602	24/59 (41%)
INO80D	XP_011509671.1	zf-C3Hc3H	50..108	CDD:290602
INO80D	XP_011509671.1	zf-C3Hc3H	476..540	CDD:290602	25/72 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145846
Domainoid	1	1.000	57	1.000	Domainoid score	I10962
eggNOG	1	0.900	-	-		E1_2C29R
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto91434
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16198
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.890