DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)L1231 and Ino80d

DIOPT Version :9

Sequence 1:	NP_001247104.1	Gene:	l(3)L1231 / 41776	FlyBaseID:	FBgn0086686	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_001178738.1	Gene:	Ino80d / 316440	RGDID:	1304808	Length:	1021	Species:	Rattus norvegicus

Alignment Length:	1031	Identity:	227/1031 - (22%)
Similarity:	354/1031 - (34%)	Gaps:	261/1031 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 PLPPSKFHHTTLAQHLQKVECLKKKKSLPLACQNNNNNSNLPNNNNVESLK-KPVVQGTSYNQTH 344
            |:|.|: .......|||.:..:.||:             ....|:.|:.:| :..:...:::.|.
  Rat    65 PIPKSE-DRRYCNSHLQVLGFIPKKE-------------RKKKNDPVDEVKVRHQMDAMAFSLTV 115

  Fly   345 PPPLMVFNTGTVAVPAQSPQTAAPQKHSTGNSVDDSDLNE----IPVNVIFRKPQEAGGAAKTGG 405
            |...:....|..::....|....|..:......|....||    :...|..||..:
  Rat   116 PTLALKMPNGLDSMSLSPPGARVPLHYLETELEDPFAFNEEDDDLKKGVTVRKKLQ--------- 171

  Fly   406 PGGLSAPVSGTPQTRPAEVKMVTP---LTPPTPPEMSAPPLLAQMQPPQIPTSCVPALAPSFKVS 467
                |.......:.|..|:..|..   .||||||:..     |.:.|  :|||..|...|...|.
  Rat   172 ----SKLAQNRQRQRETEILKVRQEHFSTPPTPPQQH-----AHLSP--LPTSLKPPAPPQGSVC 225

  Fly   468 SPAVLSPKVISPAPASPKL----LCPTAPASTNSLQIAPK-AVPATTTSSAPALAT-KSEQMSSK 526
            .         ||.|.|..|    :.||..:...:.|.:.| .:|...:|.||...| :::::..|
  Rat   226 K---------SPQPQSTSLPMQGVAPTTHSIAQTRQASHKRPLPLLPSSRAPVSDTPRTDRILMK 281

  Fly   527 VANLNAFNRQAPIASKGVRNGITNNNNNRNSNVVAKKSSPTSMPPPKDPIAPI-----AANELTD 586
            .   .||:......|             |...:|...:....:.....|...:     :..||.|
  Rat   282 A---TAFSPHFSCIS-------------RLQRLVKLCTQKHQLDADLFPHLGLDWSEESGEELED 330

  Fly   587 SEH--------------RQRRRKPASACRRSLDTLSENESFSVDSPYC--LQQHWLHSGFNNKSH 635
            |:.              ||.|       ..|.|..:|:.|..| :..|  .||.:.|
  Rat   331 SDQASPYQVAWSVRETLRQER-------HTSDDDDAESRSSRV-TQLCTYFQQKYKH-------- 379

  Fly   636 DAPLSQSNRREDRIAVRKGALRRQALQLLST------RSLQELPMRAAKQRLQCVQNMLIKYQDH 694
               |.:..|.|.|....:...|:..||..|.      :.:||| .|||..|....|..|.:.:..
  Rat   380 ---LCRLERAESRQKKCRHTFRKALLQAASKEPECTGQLIQEL-RRAACSRDSLSQTKLKEVEPA 440

  Fly   695 A--GQQQGIGIGNHCLVASCKQPTLSMAAHCERHIVNNSTQQLFQPCVAWRMDGTACQAPVFDVL 757
            |  |..:|         ..|....|....||.:||:.|.:||||..|.|...||..|..||||:.
  Rat   441 ACSGTVKG---------EQCTNQALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDIT 496

  Fly   758 HTLALCKVH-----SHLRSGMDGARPASKQPPVSLPVAGVATLYVPVKQQRKRKANTNAVARPQK 817
            |...||:.|     :.||.  |.:|....|                  ||||.:..|...|..:|
  Rat   497 HQTPLCEEHAKKMDNFLRG--DNSRKVQHQ------------------QQRKPRKKTKPPALTKK 541

  Fly   818 RGRKPANEPIANQISSQINKLIPGA---GMQRKSSTTSLESIASNSQSSAT---SHSQPPYKPGN 876
            ..:|....|...|      |.||.|   |.....::.||...||..:|.:|   |..:.|....|
  Rat   542 HKKKRRRGPRRPQ------KPIPPAVPQGNLSMPTSVSLPVQASQIRSPSTPELSADELPDDIAN 600

  Fly   877 VLAAVPAAQNLSQRSIPPALAPLSSDFQ--PNHQQQEPLLVPKLEVDSLFKFDADQQQNQQQQST 939
            .:..:|....|:|......|..|..|.|  ...:.:...|:|..|       :|::.:...|..|
  Rat   601 EITDIPHDLELNQEDFADVLPRLPDDLQDFDFFEGKNGDLLPTTE-------EAEELERALQAVT 658

  Fly   940 LDPSLLSLDIAN----IKAEEISQIVAQLAAAGGD---LQNPNNNNNNNIG-------IHNN-NS 989
            ....|.::.:.:    :..:.:|.....:.:.|.|   :|:.:...|.::|       :|:: :|
  Rat   659 SLECLSTIGVLSQSDGVPVQGLSDRGMGVFSTGTDASGIQSLSREVNTDLGELLNGRIVHDSFSS 723

  Fly   990 VHFNNNNNNSMNYSNNNNNSFPSFNTAFGNAMGQPSNTITHNGHAVPAVLANTADLLGQDMFGIC 1054
            :..:.|..:|...||      |....| |...||.|        |..:|...:|.||.|...|
  Rat   724 LELDENLLHSATLSN------PPTPLA-GQIQGQFS--------APASVGLTSATLLSQSALG-- 771

  Fly  1055 E----------NSSAYASSEDTGLGGLSESELIGT------NDADDIALNGAHLLEEH------- 1096
            |          :..::||........||:::.:.|      :|....:.:|:|...||
  Rat   772 ERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSD 836

  Fly  1097 DLVNVFDTLSDDAFNELFQSVQQAECEAM-DRALDRALQQTMGGSAD---------------SAF 1145
            .:.:...:.|.|.....|    .||...| ...|...|:..:||..:               |||
  Rat   837 HITSPHTSYSGDNMAATF----SAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSAF 897

  Fly  1146 LNDFLDVGDDLLADAVMHSPNTSGID-APPLFGDSSSGGGNSSSNGASDIRGLVQT 1200
            .| .|.....||:.::...|.||..: ..|.|       ...:.:.:|.:.||.||
  Rat   898 SN-LLGADGHLLSTSLSTPPTTSNSETTQPAF-------ATVTPSSSSVLPGLPQT 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)L1231	NP_001247104.1	zf-C3Hc3H	712..767	CDD:290602	24/59 (41%)
Ino80d	NP_001178738.1	zf-C3Hc3H	18..79	CDD:404731	3/14 (21%)
		PRK14971	<170..>285	CDD:237874	33/146 (23%)
		zf-C3Hc3H	442..506	CDD:404731	25/72 (35%)
		Herpes_BLLF1	<908..>1021	CDD:282904	11/45 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339555
Domainoid	1	1.000	57	1.000	Domainoid score	I10646
eggNOG	1	0.900	-	-		E1_2C29R
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto98514
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16198
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.890