DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)L1231 and Ino80d

DIOPT Version :9

Sequence 1:	NP_001247104.1	Gene:	l(3)L1231 / 41776	FlyBaseID:	FBgn0086686	Length:	1200	Species:	Drosophila melanogaster
Sequence 2:	NP_001108081.1	Gene:	Ino80d / 227195	MGIID:	3027003	Length:	1021	Species:	Mus musculus

Alignment Length:	1028	Identity:	224/1028 - (21%)
Similarity:	357/1028 - (34%)	Gaps:	255/1028 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 PLPPSKFH-----HTTLAQHLQKVECLKKKKSLPLACQNNNNNSNLPNNNNVESLK-KPVVQGTS 339
            |:|.|:..     |..:...:.|.|  :|||:.|                 |:.:| :..:...:
Mouse    65 PIPKSEDRRYCNSHLQVLGFIPKKE--RKKKTDP-----------------VDEVKARHQMDAMA 110

  Fly   340 YNQTHPPPLMVFNTGTVAVPAQSPQTAAPQKHSTGNSVDDSDLNE----IPVNVIFRKPQEAGGA 400
            ::.|.|...:....|..::....|....|..:......|....||    :...|..||..:
Mouse   111 FSLTVPTLALKMPNGLDSMSLSPPGARVPLHYLDTELEDPFAFNEEDDDLKKGVTVRKKLQ---- 171

  Fly   401 AKTGGPGGLSAPVSGTPQTRPAEVKMVTP---LTPPTPPEMSA--PPLLAQMQPPQIPTSCVPAL 460
                     |.......:.|..|:..|..   .||||||:...  .||...::||..|...|
Mouse   172 ---------SKLAQNRQRQRETEILKVRQEHFSTPPTPPQQHTHLSPLSTSLKPPAPPQGSV--- 224

  Fly   461 APSFKVSSPAVLSPKVISPAPASPKL-LCPTAPASTNSLQIA----PKAVPATTTSSAP-ALATK 519
                           ..||.|.:..| :...||.:.:..||.    .:.:|...:|.|| :.|.:
Mouse   225 ---------------CKSPQPQNTSLPMQGVAPTTHSIAQIRQASHKRPLPLLPSSRAPISDAPR 274

  Fly   520 SEQMSSKVANLNAFNRQAPIASKGVRNGITNNNNNRNSNVVAKKSSPTSMPPPKDPIAPI----- 579
            ::::..|.|   ||:......|             |...:|...:....:.....|...:
Mouse   275 TDRILMKAA---AFSPHLSCIS-------------RLQRLVKLCTQKRQLDADLFPHLGLDWSEE 323

  Fly   580 AANELTDSEHRQRRRKPASACRRSLDTLSENESFSVD----------SPYC--LQQHWLHSGFNN 632
            :..||.|::    :..|........:||......|.|          :..|  .||.:.|
Mouse   324 SGEELEDAD----QASPYQVAWSIRETLRHERHTSDDDDMESRSSRVTQLCTYFQQKYKH----- 379

  Fly   633 KSHDAPLSQSNRREDRIAVRKGALRRQALQLLST------RSLQELPMRAAKQRLQCVQNMLIKY 691
                  |.:..|.|.|....:...|:..||..|.      :.:||| .|||..|....|..|.:.
Mouse   380 ------LCRLERAESRQKKCRHTFRKALLQAASKEPECTGQLIQEL-RRAACSRASLRQTKLKEV 437

  Fly   692 QDHA--GQQQGIGIGNHCLVASCKQPTLSMAAHCERHIVNNSTQQLFQPCVAWRMDGTACQAPVF 754
            :..|  |..:|         ..|.:..|....||.:||:.|.:||||..|.|...||..|..|||
Mouse   438 EPAACSGTVKG---------EQCTKQALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVF 493

  Fly   755 DVLHTLALCKVH-----SHLRSGMDGARPASKQPPVSLPVAGVATLYVPVKQQRKRKANTNAVAR 814
            |:.|...||:.|     :.||.  |.:|....|                  ||||.:..|...|.
Mouse   494 DITHQTPLCEEHAKKMDNFLRG--DNSRKVQHQ------------------QQRKPRKKTKPPAL 538

  Fly   815 PQKRGRKPANEPIANQISSQINKLIPGA---GMQRKSSTTSLESIASNSQSSAT---SHSQPPYK 873
            .:|..:|....|...|      |.||.|   |.....::.||...||..:|.:|   |..:.|..
Mouse   539 TKKHKKKRRRGPRRPQ------KPIPPAVPQGNLSMPTSVSLPVEASQMRSPSTPELSADELPDD 597

  Fly   874 PGNVLAAVPAAQNLSQRSIPPALAPLSSDFQ--PNHQQQEPLLVPKLEVDSLFKFDADQQQNQQQ 936
            ..|.:..:|....|:|......|..|..|.|  ...:.:...|:|..|       :|::.:...|
Mouse   598 IANEITDIPHDLELNQEDFADVLPRLPDDLQDFDFFEGKNGDLLPTTE-------EAEELERALQ 655

  Fly   937 QSTLDPSLLSLDIAN----IKAEEISQIVAQLAAAGGD---LQNPNNNNNNNIG-IHNNNSVHFN 993
            ..|....|.::.:.:    :..:.:|.....:.:.|.|   :|:.:...|.::| :.|...||
Mouse   656 AVTSLECLSTIGVLSQSDGVPVQGLSDRGMGVFSTGTDASGIQSLSREVNTDLGELLNGRIVH-- 718

  Fly   994 NNNNNSMNYSNNNNNSFP--SFNTAF-GNAMGQ---PSNTITHNGHAVPAVLANTADLLGQDMF- 1051
             ::.:|:....|..:|.|  |..||. |...||   |::.    |.....:|:.:|  ||:..|
Mouse   719 -DSFSSLELDENLLHSAPLSSPPTALAGQIQGQFSAPASA----GLTSATLLSQSA--LGERAFP 776

  Fly  1052 ----GICENSSAYASSEDTGLGGLSESELIGT------NDADDIALNGAHLLEEH-------DLV 1099
                |:.:.|.|........|  ||:::.:.|      :|....:.:|:|...||       .:.
Mouse   777 GQFHGLHDGSHASQRPHPAQL--LSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHIT 839

  Fly  1100 NVFDTLSDDAFNELFQSVQQAECEAM-DRALDRALQQTMGGSAD---------------SAFLND 1148
            :...:.|.|.....|    .||...| ...|...|:..:||..:               |||.|
Mouse   840 SPHTSYSGDNMAATF----SAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSAFSN- 899

  Fly  1149 FLDVGDDLLADAVMHSPNTSGID-APPLFGDSSSGGGNSSSNGASDIRGLVQT 1200
            .|.....||:.::...|.||..: ..|.|       ...:.:.:|.:.||.||
Mouse   900 LLGADGHLLSTSLSTPPTTSNSETTQPAF-------ATVTPSSSSVLPGLPQT 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)L1231	NP_001247104.1	zf-C3Hc3H	712..767	CDD:290602	24/59 (41%)
Ino80d	NP_001108081.1	zf-C3Hc3H	18..79	CDD:372789	3/13 (23%)
		PRK14971	<170..>300	CDD:237874	35/176 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..239		16/62 (26%)
		zf-C3Hc3H	442..506	CDD:372789	25/72 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..570		19/81 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	808..844		5/35 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..940		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..1021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835917
Domainoid	1	1.000	57	1.000	Domainoid score	I10893
eggNOG	1	0.900	-	-		E1_2C29R
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto95015
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16198
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920