DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7886 and NOD2

DIOPT Version :9

Sequence 1:NP_650378.1 Gene:CG7886 / 41775 FlyBaseID:FBgn0038248 Length:818 Species:Drosophila melanogaster
Sequence 2:NP_071445.1 Gene:NOD2 / 64127 HGNCID:5331 Length:1040 Species:Homo sapiens


Alignment Length:231 Identity:47/231 - (20%)
Similarity:90/231 - (38%) Gaps:57/231 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 QRPVIYTRFIFNSLVQAIANCVSSNKNLSVLKLEGLPLQDGYIETIAKALADNECLESVSFRKSN 190
            |:..::...:.:....::|..::..:|...|:|....:.....:.:|:.|..|..|:.:.|..:.
Human   846 QKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNR 910

  Fly   191 IGDKGCEVVCNTAKYLNRIEVFDLSECGLTSKGAEHVADMLKMQKITRFTEGWEKSLRYRSVDVN 255
            :||:|.:.:                        ||.:.|              .:|||:.|:..|
Human   911 VGDEGAQAL------------------------AEALGD--------------HQSLRWLSLVGN 937

  Fly   256 TIGGLRTVLLA--------------DNPEIGDVGIRWITEVLKEDAWIKKIDMEGCGLTDIGANL 306
            .||.:....||              :...:.|.|:..:.|.||:::.:|.:.:....:|.:||..
Human   938 NIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEA 1002

  Fly   307 ILDCLELNTAITEFNVRNNEGISKFLQRSIHDRLGC 342
            :|..||.|..|.|..:|.|    .|....: |:|||
Human  1003 LLQALERNDTILEVWLRGN----TFSLEEV-DKLGC 1033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7886NP_650378.1 LRR_RI <142..320 CDD:238064 38/191 (20%)
leucine-rich repeat 153..180 CDD:275381 5/26 (19%)
leucine-rich repeat 181..208 CDD:275381 5/26 (19%)
leucine-rich repeat 209..246 CDD:275381 3/36 (8%)
leucine-rich repeat 260..285 CDD:275381 6/38 (16%)
NOD2NP_071445.1 DD 34..119 CDD:301326
ATG16L1-binding motif 63..77
CARD_NOD2_2_CARD15 134..214 CDD:260056
Required for CARD9 binding. /evidence=ECO:0000269|PubMed:24960071 241..274
NACHT 293..463 CDD:283404
leucine-rich repeat 764..791 CDD:275381
LRR_RI 767..1032 CDD:238064 44/228 (19%)
LRR 1 791..812
LRR <795..1040 CDD:227223 47/231 (20%)
leucine-rich repeat 795..816 CDD:275380
LRR 2 816..839
leucine-rich repeat 820..844 CDD:275380
LRR 3 844..865 1/18 (6%)
leucine-rich repeat 845..868 CDD:275380 2/21 (10%)
leucine-rich repeat 869..900 CDD:275380 6/30 (20%)
LRR 4 872..884 3/11 (27%)
LRR 5 900..920 5/43 (12%)
leucine-rich repeat 901..928 CDD:275380 8/64 (13%)
LRR 6 928..949 8/20 (40%)
leucine-rich repeat 929..952 CDD:275380 8/22 (36%)
LRR 7 956..976 2/19 (11%)
leucine-rich repeat 957..984 CDD:275380 5/26 (19%)
LRR 8 984..1005 4/20 (20%)
leucine-rich repeat 985..1006 CDD:275380 5/20 (25%)
LRR 9 1012..1032 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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