DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7886 and Cep78

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_068509.2	Gene:	Cep78 / 60347	RGDID:	620464	Length:	789	Species:	Rattus norvegicus

Alignment Length:	822	Identity:	180/822 - (21%)
Similarity:	316/822 - (38%)	Gaps:	187/822 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 HFRYLELCRAKNLTPVPEIRSKSNATTTFLELCGDKLAVSDWQLLTEALHYDLVLQQLVVRLRRT 106
            |:.|  ||..::..|:|.:|  :......|:...|:|...||..|..:|           |:.|.
  Rat    18 HYEY--LCALQDSAPLPAVR--ACLRDGVLDFNADRLRAVDWAPLLSSL-----------RVNRD 67

  Fly   107 YP----QTNIDPIDTEK--------RARLFRQR-PVIYTRFIFNSLVQAIANCVSSNKNLSVLKL 158
            .|    :::..|...|.        ..|:.|.| |.:.::.|...|.:|:..|:|.:..|..|:|
  Rat    68 LPLVAIKSSFQPWLGESVLRSGGADAHRVCRNRVPSVRSKDISFQLCKALKGCLSVSGVLRNLEL 132

  Fly   159 EGLPLQDGYIETIAKALADNECLESVSFRKSNIGDKGCEVVCNTAKYLNRIEVFDLSECGLTSKG 223
            .||.|::..:.::.|.|:.:..|..:|.....:||.|.|::|...|....::..:.:.|.||.:|
  Rat   133 NGLILRERDLTSLTKGLSKSASLVHLSLANCPVGDGGLEIICQGIKNSVTLKTVNFTGCNLTWQG 197

  Fly   224 AEHVADMLKMQKITRFTEGWEKSLRYRSVDVNTIGGLRTVLLADNPEIGDVGIRWITEVLKEDAW 288
            |.|:|.:||.|.:.|..|.|.:|||||..|::.:.|||.:.|..|..|||.|.....:.|.||.|
  Rat   198 ASHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDQGASAFADSLSEDLW 262

  Fly   289 IKKIDMEGCGLTDIGANLILDCLELNTAITEFNVRNNEGISKFLQRSIHDRL---GCLPEEKQEP 350
            ::.:|::.||||..||..:|:.||.|..:...::|.|..|...:.:::..::   |    .....
  Rat   263 LRALDLQQCGLTSEGAKALLEALETNRTLVVLDIRKNPLIDHSMMKAVIRKVLQNG----RSATS 323

  Fly   351 EYDLSCVNGLQSLP---KNKKVTVSQLLSHTKALEEQLSFERTLRKKAEKLNEKLSHQLMRPDSN 412
            ||.......|:.||   |.||.|:        .|......:.|:|.
  Rat   324 EYQWVTSPSLKELPKTTKQKKKTI--------VLGSSRKGKATIRV------------------- 361

  Fly   413 HMVQEKAMEGGSQTNISREYVARNDVMPEVIKNSQSYRQSHFNRLVNSAATSPEVTPRSEIVTLR 477
            .:..:|.:..|.:..:|::                            |.|..|.....|..:..|
  Rat   362 GLATKKPVSNGRKHGLSKD----------------------------SYAPDPLPPGASGFLPWR 398

  Fly   478 KEQQLQRQQPPPMEVKH-LSLEQQIRNLRDVQKKVDLDVEEEEEEEEEEQQAEESQSESEPQNEE 541
            ..::.:|.:..|:...| ||     .:|:.....|.:.||.....|.:         |||..:|.
  Rat   399 TAERARRNRSFPLIKTHDLS-----NHLQQSDFPVTVTVESPSSSETD---------ESEDSSES 449

  Fly   542 QQHYEQQMQVQRKHLQVRKVRSEIKYVENNPKEAAKKN-RESKSDHEFANER--DFKLNPSVQFE 603
            .....|:..::::.|| .|:...:|.::.......|.: |.|:.:||.|..|  :|.|:.::|.:
  Rat   450 VHEVPQKTSIRQETLQ-EKLEECLKQLKEERVTRLKTDKRISELEHENAQLRNINFSLSEALQAQ 513

  Fly   604 TDIGDNVMVNPG------------HRY-----EGGGGDTAYVYNYEHEQQQQPVKRGYEHGYVVG 651
            : :...::.:.|            |.:     :.|.|..|.:...:...           .:::|
  Rat   514 S-LTSMILDDEGVLGSIENSFQKFHAFLDLLKDAGLGQLATMAGIDQSD-----------FHLLG 566

  Fly   652 VGDGSHRRQRQSQLVEALVQKRVPGASDGHVAQFVSNLE-RQANAG--------KTGKKRLKPRP 707
                   |.:.|..|...|::: .|..|       .||: :|...|        |.....:.|.|
  Rat   567 -------RPQMSSTVNTPVEEQ-KGLED-------ENLDLKQTAVGQMQDIGFQKITSDPMVPLP 616

  Fly   708 EDDLQVPVGDMHMESS-------------------YMSRSEELSSTDVTLENSDYETEATDSTLL 753
            .|..|||........|                   :::.:...|:..::...|..|...:..:..
  Rat   617 LDTNQVPASTQEAAGSSRDHLGVVALEQQEGSAVGFIAITGSPSADGISGGRSLEEVVLSKHSRS 681

  Fly   754 SSSKYSSMHVFVRRKQSESMSLTEEAGDGDA---GGGGGSGD 792
            ||.|.|:.....||:.:|..|..:...|.|:   ..|.|.|:
  Rat   682 SSGKGSTASEPSRRQSAERHSRKDLHSDSDSPVNSKGKGPGE 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	62/177 (35%)
		leucine-rich repeat	153..180	CDD:275381	8/26 (31%)
		leucine-rich repeat	181..208	CDD:275381	8/26 (31%)
		leucine-rich repeat	209..246	CDD:275381	13/36 (36%)
		leucine-rich repeat	260..285	CDD:275381	9/24 (38%)
Cep78	NP_068509.2	LRR_RI	<113..299	CDD:238064	64/185 (35%)
Cep78	NP_068509.2	PhaP_Bmeg	<413..485	CDD:299060	17/86 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006566
OrthoInspector	1	1.000	-	-		oto98556
orthoMCL	1	0.900	-	-		OOG6_106357
Panther	1	1.100	-	-	LDO	PTHR24110
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5564
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.700