DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7886 and cep78

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_009302592.1	Gene:	cep78 / 564741	ZFINID:	ZDB-GENE-070905-1	Length:	672	Species:	Danio rerio

Alignment Length:	811	Identity:	184/811 - (22%)
Similarity:	313/811 - (38%)	Gaps:	206/811 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PLVKKSSKSRSFHFRYLELCRAKNLTPVPEIRSKSNATTTFLELCGDKLAVSDWQLLTEALHYDL 94
            |...:...::.|...|..||.|:...||..:  |:..:...||...|:|:::||..:..||..:.
Zfish     4 PAQSRRRGAQDFEGYYDHLCAAQGSAPVRAV--KACLSRGVLEFNPDQLSLADWTPVLSALAINK 66

  Fly    95 VLQQLVVR---LRRTYPQTNIDPIDTEKRARLFRQRPVIYTRFIFNSLVQAIANCVSSNKNLSVL 156
            .|.|:.:|   |..|..|....|.:.:|       .|.|:::.:...|.:|:..|:..:.:|..|
Zfish    67 HLHQVSIRSCHLLSTGAQNVYRPHNKKK-------TPAIHSKTVSLQLCKAVQKCLCESSSLRTL 124

  Fly   157 KLEGLPLQDGYIETIAKALADNECLESVSFRKSNIGDKGCEVVCNTAKYLNRIEVFDLSECGLTS 221
            :|..|||::..:..:.|.||.:..||.:|.....|||:|.||:|.:.||.:.|:..|.:.|.:|.
Zfish   125 QLHALPLRERDLTALTKGLAKSVSLEHLSLAHCPIGDQGLEVICQSVKYSSTIKGVDFTSCNITW 189

  Fly   222 KGAEHVADMLKMQKITRFTEGWEKSLRYRSVDVNTIGGLRTVLLADNPEIGDVGIRWITEVLKED 286
            :||||:|:::|.|.:.|.:..|.::||||..:...:.|||.:.|.||..|||.|:..:...|.||
Zfish   190 QGAEHMANIIKHQAMRRHSTAWVETLRYRRAEFEAMNGLRRITLNDNILIGDRGVSALARELTED 254

  Fly   287 AWIKKIDMEGCGLTDIGANLILDCLELNTAITEFNVRNNEGISKFLQRSIHDRLGCLPEEKQEPE 351
            .|:|.:|::.||:::.||.::...|:.|:.:...::|.|                        |.
Zfish   255 LWVKAVDLQRCGISNDGAQVLEQMLQSNSTLCVLDIRRN------------------------PL 295

  Fly   352 YDLSCVNGLQSLPKNKKVTVSQLLSHTKALEEQLSF-------------ERTLRKKAEKLNEKLS 403
            .|.:.|          |..:.::|.:||.|:.|..:             .:..||.|.|...::.
Zfish   296 IDNNVV----------KAVLKKVLMNTKNLDSQYLWLKPPSPKDSADQSRQFRRKNAGKATYRIG 350

  Fly   404 HQLMRPDSNHMVQEKAMEGGSQTNISREYVARNDVMPEVIKNSQSYRQSHFNRLVNSAATSPEVT 468
               .|..|:.:...:....||...|.....||.|:.....:......||..|      |||.:||
Zfish   351 ---SRRSSSVISVFRPPRPGSTGYIPWRTAARADLQRGASRADGRTDQSFQN------ATSVQVT 406

  Fly   469 PRSEIVTLRKEQQLQRQQPPPMEVKHLSLEQQIRNLRDVQKKVDLDVEEEEEEEEEEQQAEESQS 533
                                                          ||.|.|.|:.|.:..||.
Zfish   407 ----------------------------------------------VETESESEDVEAKDVESP- 424

  Fly   534 ESEPQNEEQQHYEQQMQVQRKHLQVRKVRSEIKYVENNPKEAAKKNRESKSDH-----EFANERD 593
                       .|:....|.:.||....|.:::..|...:.|.::|...|::.     |..|||.
Zfish   425 -----------LEKITSYQFRRLQTENNRLKVELEECRLRLAEERNTRLKANSRLVELELENERL 478

  Fly   594 FKLNPSVQFETDIGDNVMVNPGHRYEGGGGDTAYVYNYEHEQQQQPVKRGYEHGYVVGVGDGSHR 658
            ..:|.|:. |..|..:|:                    |.|:..:.::..:            |:
Zfish   479 RTMNQSLS-EAHISSSVL--------------------EDERVLESIESSF------------HK 510

  Fly   659 RQRQSQLVEALVQKRVPGASDGHVAQFVS--NLERQANAGKTGKKRLK---------PRPED--D 710
            ......|::           |..:.||.|  .:| |::.|..|:.:|.         .|.||  :
Zfish   511 FHAFLDLLK-----------DAGLGQFASMAGIE-QSDFGVVGRPQLSSTERTHTGPARHEDRRN 563

  Fly   711 LQVPVGDMHMESSYMSRSEELSSTDVTLENSDYETEATDSTLLSSSKYSSMHVFVRRKQSESM-S 774
            ...||...|.||.  :|.|..:.|:...:...::.|.             :|..:..:.|.:: .
Zfish   564 SSAPVDVPHPESG--TRPEPPADTEDLPQPRPHQEEL-------------LHPVISSRSSPALQE 613

  Fly   775 LTEEAGDGDAGGGGGSGDFGDQNVISPANVY 805
            |...||.| :||...|.....:...|..:||
Zfish   614 LDLRAGSG-SGGSVSSVSLQSRGSPSSRSVY 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	62/177 (35%)
		leucine-rich repeat	153..180	CDD:275381	9/26 (35%)
		leucine-rich repeat	181..208	CDD:275381	12/26 (46%)
		leucine-rich repeat	209..246	CDD:275381	13/36 (36%)
		leucine-rich repeat	260..285	CDD:275381	10/24 (42%)
cep78	XP_009302592.1	LRR_RI	12..293	CDD:238064	90/289 (31%)
		leucine-rich repeat	101..125	CDD:275381	4/23 (17%)
		leucine-rich repeat	126..145	CDD:275381	6/18 (33%)
		leucine-rich repeat	149..176	CDD:275381	12/26 (46%)
		leucine-rich repeat	177..203	CDD:275381	10/25 (40%)
		leucine-rich repeat	204..227	CDD:275381	6/22 (27%)
		leucine-rich repeat	228..250	CDD:275381	9/21 (43%)
		leucine-rich repeat	251..284	CDD:275381	12/32 (38%)
		leucine-rich repeat	285..307	CDD:275381	6/55 (11%)
		MreC	<425..>542	CDD:302802	29/161 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006566
OrthoInspector	1	1.000	-	-		oto41254
orthoMCL	1	0.900	-	-		OOG6_106357
Panther	1	1.100	-	-	LDO	PTHR24110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5564
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.700