DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7886 and nlrx1

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_021322089.1	Gene:	nlrx1 / 557335	ZFINID:	ZDB-GENE-071119-3	Length:	1005	Species:	Danio rerio

Alignment Length:	441	Identity:	82/441 - (18%)
Similarity:	153/441 - (34%)	Gaps:	130/441 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VLQQLVVRLRRTYPQTNIDPIDTEKRARLFRQRP----VIYTRFIFNSLVQAIANCVSSNKNLSV 155
            :...:...:.|:....|.|.:|..:::.|....|    .||||..  .|.......:....|..:
Zfish   595 IANTMAAEMFRSEDSFNEDVLDQVEQSLLGVHGPQPQEEIYTRAF--ELYPIFMGGLLHYGNRRL 657

  Fly   156 LKLEGLPLQDGYIETIAKALADN----------------------------------ECLESVSF 186
            |...|..::...:..|.:||..|                                  :.::|::.
Zfish   658 LDQLGCNIKSHTVSQITRALRKNLIKQSQKNQPPEELMDLLVLLYEFQNPRLTAEVLQSIKSLNL 722

  Fly   187 RKSNIGDKGCEVV-----CNTAKY-LNRIEVFDLSECGLTSKGAEHVADMLKMQKITRFTEGWEK 245
            ....:....|.|:     |.|:.: ||.:   :||.|        |:...|.......|......
Zfish   723 STVRMTPHKCFVLSTVLGCTTSSFHLNEL---NLSSC--------HITPELLQMLWPAFRHTRNL 776

  Fly   246 SLRYRSVDVNTIGGLRTVLLADNPEI----------GDVGIRWITEVLKEDAWIKKIDMEGCGLT 300
            :|::.|:|..:...||.:||..|..|          .|.||..:.|.|..:..::::::...||:
Zfish   777 NLQFNSLDPESCILLRDLLLEPNCTIKSLQLCDNYLSDSGISHLLEALSGNHSLQRLNLMHTGLS 841

  Fly   301 DIGANLILDCLELNTAITEFNVR-NNEGISKFLQ-----------RSIHDRLGCLPEEKQEPEYD 353
            |..|.|:.:.|..:..:.|.||. ||.|.|..|.           .::|..|..|.:..::..|
Zfish   842 DKSALLLAEKLGQHDQLKELNVAYNNIGDSAALTLVDACREHPSIHTVHLYLNQLTDVAKQSLY- 905

  Fly   354 LSCVNGLQSLPKNKKVTVSQLLSHTKALEE------------QLSFERTLRKKAEKLNEKLSHQL 406
               |.|...:.:.::|.|...::....:.|            .||:||      :::.|:|
Zfish   906 ---VRGGPRVKEGRRVKVLASVTEGSDISEDWHPILSVIGKNSLSWER------DRVREQL---- 957

  Fly   407 MRPDSNHMVQEKAMEGGSQTNISREYVARNDVMPEVIKNSQSYRQSHFNRL 457
                   :|..|.:|.|.:.::|                  .:::.||.|:
Zfish   958 -------LVFLKDLEWGRKQHLS------------------FWKKMHFRRV 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	40/227 (18%)
		leucine-rich repeat	153..180	CDD:275381	6/60 (10%)
		leucine-rich repeat	181..208	CDD:275381	6/32 (19%)
		leucine-rich repeat	209..246	CDD:275381	6/36 (17%)
		leucine-rich repeat	260..285	CDD:275381	11/34 (32%)
nlrx1	XP_021322089.1	P-loop_NTPase	179..338	CDD:328724
		LRR_RI	664..904	CDD:330982	48/250 (19%)
		leucine-rich repeat	717..740	CDD:275380	3/22 (14%)
		leucine-rich repeat	748..777	CDD:275381	8/39 (21%)
		leucine-rich repeat	778..801	CDD:275381	8/22 (36%)
		leucine-rich repeat	802..829	CDD:275381	6/26 (23%)
		leucine-rich repeat	830..857	CDD:275381	6/26 (23%)
		leucine-rich repeat	858..885	CDD:275381	8/26 (31%)
		leucine-rich repeat	886..911	CDD:275381	6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900