DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7886 and lrrc34

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001373409.1	Gene:	lrrc34 / 556175	ZFINID:	ZDB-GENE-091118-73	Length:	410	Species:	Danio rerio

Alignment Length:	393	Identity:	80/393 - (20%)
Similarity:	151/393 - (38%)	Gaps:	106/393 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RYLELCRAKNLTP----VPEIRSKSNATTTFLELCGD-----KLAVSDWQLLTEALHYDLVLQQL 99
            |||.:| |:...|    |.|:...:.::...|:|.|:     :|...|..:||:.|..:..::.|
Zfish     7 RYLSVC-AELQQPTHASVLEVLGNNKSSDCCLKLAGNDQPGARLTDDDMLVLTKTLEGNSAIKGL 70

  Fly   100 VVRLRRTYPQTNIDPIDTEKRARLFRQRPVIYTRFIFNSLVQAIANCVSSNKNLSVLKLEGLPLQ 164
            .:|..          ..|:|.|                   ..||:.:..:|:|..|.|....::
Zfish    71 DLRYN----------CITDKGA-------------------VHIAHLIQDSKSLQSLDLMCNDIE 106

  Fly   165 DGYIETIAKALADNECLESVSFRKSNIGDKGCEVVCNTAKYLNRIEVFDLSECGLTSKGAEHVAD 229
            ....|.|||:|..|..|:::....:.||::|...:....:....:|..|:|:|.|.::.....|.
Zfish   107 ADGAEVIAKSLHKNITLKTLRMTGNKIGNQGAMQLATMLQINATLEEVDVSDCDLATQSVIAFAI 171

  Fly   230 MLKMQKITRFTEGWEKSLRYRSVDVN----------TIGGLRTVLLADNP---------EIGDVG 275
            :|...|            |..:::|:          |...:..:|:.:|.         ::.|.|
Zfish   172 VLMNNK------------RICAINVSRPLLFSLQEETTVHMAQMLVVNNTLKELHMGKHDMTDTG 224

  Fly   276 IRWITEVLKEDAWIKKIDMEGCGLTDIGANLILDCLELNTAI----TEFNVRNNEGISKFLQRSI 336
            :..:.|.||.:..::.:|:....:|..||..:.:.|:.|.::    ..||...:.|       :|
Zfish   225 VETLCEALKRNISLRYLDLCCNRITRDGAKHLSEVLKQNCSLEILDLSFNCIEDVG-------AI 282

  Fly   337 HDRLGCLPEEKQEPEYDLSCVNGLQSLPKNKKVTVSQLLSHTKALEEQLSFERTLRKKAEKLNEK 401
            |     |.|..:.|...|..:    |:..| |:....|||.:.|:               ::|..
Zfish   283 H-----LSEAIKLPHSKLKAL----SVTSN-KIRKGGLLSLSAAM---------------RVNSS 322

  Fly   402 LSH 404
            |:|
Zfish   323 LTH 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	40/200 (20%)
		leucine-rich repeat	153..180	CDD:275381	9/26 (35%)
		leucine-rich repeat	181..208	CDD:275381	4/26 (15%)
		leucine-rich repeat	209..246	CDD:275381	8/36 (22%)
		leucine-rich repeat	260..285	CDD:275381	6/33 (18%)
lrrc34	NP_001373409.1	RNA1	<21..>138	CDD:227563	30/145 (21%)
		leucine-rich repeat	67..94	CDD:275381	7/55 (13%)
		LRR_RI	<95..332	CDD:423007	56/275 (20%)
		leucine-rich repeat	95..122	CDD:275380	9/26 (35%)
		leucine-rich repeat	123..150	CDD:275380	4/26 (15%)
		leucine-rich repeat	151..178	CDD:275380	8/38 (21%)
		leucine-rich repeat	179..202	CDD:275380	2/22 (9%)
		leucine-rich repeat	210..237	CDD:275380	5/26 (19%)
		leucine-rich repeat	238..265	CDD:275380	6/26 (23%)
		leucine-rich repeat	266..292	CDD:275380	7/37 (19%)
		leucine-rich repeat	323..344	CDD:275380	2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900