DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7886 and NLRP9

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_789790.2	Gene:	NLRP9 / 338321	HGNCID:	22941	Length:	991	Species:	Homo sapiens

Alignment Length:	448	Identity:	92/448 - (20%)
Similarity:	149/448 - (33%)	Gaps:	151/448 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 HFRYLELCRAKNLTPVPE--IRSKSNATTTFLELCGDKLAVSDWQLL-TEALHYD--------LV 95
            |...|.:| .:|:.|...  |...:.....:.|||...:...::|:| .|....|        ..
Human   590 HLTTLRMC-VENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKA 653

  Fly    96 LQQLVVRLRRTYPQTNIDPIDTEKRARLFRQRPVIYTRFIF---NSLVQAIANCVSSNKNLSVLK 157
            |.|.|.:||:                       :|:|...|   :.|.:|:.:    |.:|.:|.
Human   654 LAQPVCKLRK-----------------------LIFTSVYFGHDSELFKAVLH----NPHLKLLS 691

  Fly   158 LEGLPLQDGYI-----------------------------ETIAKALADNECLESVSFRKSNIGD 193
            |.|..|....|                             |.||..||.|..|:.:|..::.:.|
Human   692 LYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRD 756

  Fly   194 KGCEVVCNTAKYLN-RIEVFDLSECGLTSKGAEHVADMLKMQKITRFTEGWEKSLRYRSVDVNTI 257
            :|..::|...|:.: .:|...|..|.|||...:.::::|..          .|||....:..|.
Human   757 EGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC----------SKSLSLLDLGSNA- 810

  Fly   258 GGLRTVLLADNPEIGDVGIRWITEVLKEDAW-IKKIDMEGCGLT-----DIGANLILDCLELNTA 316
                   |.||      |:..:...||.... |:::.:.||.||     ||.|.||.:. :|.|.
Human   811 -------LEDN------GVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNG-KLKTL 861

  Fly   317 ITEFNVRNNEGISKFLQRSIHDRLGCLPEEKQEPEYDLSCVNGLQSLPKNKK------------- 368
            ....|...:.|:.:            |....|.|...|.|: |||:.|..:.
Human   862 KLGHNEIGDTGVRQ------------LCAALQHPHCKLECL-GLQTCPITRACCDDIAAALIACK 913

  Fly   369 -----------------VTVSQLLSHTKALEEQL-----SFERTLRKKAEKLNEKLSH 404
                             |.:.:.|||.....:.|     .|:...:|....:.||:.|
Human   914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPH 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	49/213 (23%)
		leucine-rich repeat	153..180	CDD:275381	12/55 (22%)
		leucine-rich repeat	181..208	CDD:275381	6/27 (22%)
		leucine-rich repeat	209..246	CDD:275381	7/36 (19%)
		leucine-rich repeat	260..285	CDD:275381	5/24 (21%)
NLRP9	NP_789790.2	Pyrin_NALPs	11..93	CDD:260032
		NACHT	146..314	CDD:310381
		LRR_RI	622..897	CDD:330982	74/339 (22%)
		LRR 1	743..763		4/19 (21%)
		LRR 2	772..793		6/20 (30%)
		LRR 3	800..820		7/33 (21%)
		LRR 4	829..850		7/20 (35%)
		LRR 5	857..877		4/31 (13%)
		LRR 6	886..907		6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900