DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7886 and Nod2

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_038953498.1	Gene:	Nod2 / 291912	RGDID:	1306368	Length:	1012	Species:	Rattus norvegicus

Alignment Length:	335	Identity:	67/335 - (20%)
Similarity:	130/335 - (38%)	Gaps:	70/335 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SVPPLVKKSSKSRSFHFRYLELCRAKNLTPVPEIRSKSNATTTF----LELCGDKLAVSDWQLLT 87
            |:||.|...:||......::.|.|  :|..:.|::....|....    |:|...::..::...|.
  Rat   693 SIPPAVPGETKSMHAMPGFIWLIR--SLYEMQEVQLAREAVRRLDIGHLKLTFCRVGPAECAALA 755

  Fly    88 EALHY---------------DLVLQQLV--------VRLRRTYPQTNIDPIDTEKRARLF----- 124
            ..|.:               |:.::||:        :.||    ..||    :::.||..
  Rat   756 FVLQHLQRPVALQLDHNSVGDVGVEQLLPCLGVCTALYLR----DNNI----SDRGARTLVECAL 812

  Fly   125 ----RQRPVIYTRFIFNSLVQAIANCVSSNKNLSVLKLEGLPLQDGYIETIAKALADNECLESVS 185
                .|:..::...:.:....::|..::..:|...|::....:.....|.:|:.|..|..|:.:.
  Rat   813 RCEQLQKLALFNNKLTDGCASSVAKLLAHKQNFLSLRVGNNHITAAGAEVLAQGLKSNTSLQFLG 877

  Fly   186 FRKSNIGDKGCEVVCNTAKYLNRIEVFDLSECGLTSKGAEHVADMLKMQKITRFTEGWEKSLRYR 250
            |..:::||||.:.:........|::...|....:.|.||..:|.||:..|
  Rat   878 FWGNSVGDKGSQALAEVVADHQRLKWLSLVGNNIGSVGAHALALMLEKNK--------------- 927

  Fly   251 SVDVNTIGGLRTVLLADNPEIGDVGIRWITEVLKEDAWIKKIDMEGCGLTDIGANLILDCLELNT 315
                    .|..:.|.:| .|.|.|:..:.|.||.::.:|.:.:...|:|..||..:|..|..|:
  Rat   928 --------SLEELCLEEN-HICDEGVYSLAEGLKRNSTLKFLKLSNNGITYRGAEALLQALNRNS 983

  Fly   316 AITEFNVRNN 325
            .:.|..:|.|
  Rat   984 TVLEVWLRGN 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	39/177 (22%)
		leucine-rich repeat	153..180	CDD:275381	5/26 (19%)
		leucine-rich repeat	181..208	CDD:275381	6/26 (23%)
		leucine-rich repeat	209..246	CDD:275381	8/36 (22%)
		leucine-rich repeat	260..285	CDD:275381	8/24 (33%)
Nod2	XP_038953498.1	DD	7..87	CDD:417479
		DD	107..186	CDD:417479
		NACHT	266..436	CDD:399032
		NOD2_WH	518..574	CDD:407651
		NLRC4_HD2	576..729	CDD:407648	10/37 (27%)
		LRR_RI	<752..984	CDD:423007	51/263 (19%)
		leucine-rich repeat	786..816	CDD:275380	6/37 (16%)
		leucine-rich repeat	817..844	CDD:275380	2/26 (8%)
		leucine-rich repeat	845..872	CDD:275380	5/26 (19%)
		leucine-rich repeat	873..900	CDD:275380	6/26 (23%)
		leucine-rich repeat	901..928	CDD:275380	8/49 (16%)
		leucine-rich repeat	929..953	CDD:275380	8/24 (33%)
		leucine-rich repeat	957..978	CDD:275380	6/20 (30%)
		leucine-rich repeat	979..1006	CDD:275380	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900