DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7886 and Nlrc3

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_011244204.1	Gene:	Nlrc3 / 268857	MGIID:	2444070	Length:	1109	Species:	Mus musculus

Alignment Length:	323	Identity:	63/323 - (19%)
Similarity:	122/323 - (37%)	Gaps:	90/323 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 TRFIFNSLVQAIANCVSSNKNLSVLKLEGLPLQDGYIETIAKALADNEC-LESVSFRKSNIGDKG 195
            ::.:..||:..:..|.|       |:|:....||..:|.:...|:..:| :..:|..::.||:||
Mouse   662 SQHVLQSLLPQLLYCQS-------LRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKG 719

  Fly   196 CEVVCNTAKYLNRIEVFDLSECGLTSKGAEHVADMLKMQK-ITRFT--------EG--------- 242
            .:.:..:......:...||....:...||:.:||.||:.: :|..:        :|
Mouse   720 AKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVAEALV 784

  Fly   243 WEKSLRYRSVDVNTIG---------------GLRTVLLADNPEIGDVGIRWITEVLKEDAWIKKI 292
            ..:::....:..|.||               .|:.::.:.| .|||.|...:.|.||.:..::.:
Mouse   785 SNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSN-TIGDRGAIALAEALKVNQILENL 848

  Fly   293 DMEGCGLTDIGANLILDCLELNTAITEFNVRNN----EGISKFLQ---------------RSIHD 338
            |::...::|:|..:::..|..|..::..|:|.|    ||.....|               ..:||
Mouse   849 DLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHD 913

  Fly   339 RLGCLPEEKQEPEYDLSCVNGLQSLP----KNKKVTVSQL------LSHTKALEEQLSFERTL 391
            |                   |.|::.    :|..:|...|      ....:||.:.|...|||
Mouse   914 R-------------------GAQAIAVAVGENHSLTHLHLQWNFIQAGAARALGQALQLNRTL 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	41/211 (19%)
		leucine-rich repeat	153..180	CDD:275381	6/26 (23%)
		leucine-rich repeat	181..208	CDD:275381	5/26 (19%)
		leucine-rich repeat	209..246	CDD:275381	10/54 (19%)
		leucine-rich repeat	260..285	CDD:275381	8/24 (33%)
Nlrc3	XP_011244204.1	NACHT	176..342	CDD:368582
		NOD2_WH	432..490	CDD:375327
		NLRC4_HD2	492..617	CDD:375325
		LRR_RI	<662..863	CDD:393385	41/208 (20%)
		leucine-rich repeat	673..701	CDD:275380	8/34 (24%)
		leucine-rich repeat	705..730	CDD:275380	5/24 (21%)
		leucine-rich repeat	733..760	CDD:275380	8/26 (31%)
		leucine-rich repeat	761..788	CDD:275380	2/26 (8%)
		leucine-rich repeat	789..816	CDD:275380	3/26 (12%)
		LRR_RI	792..1097	CDD:393385	37/186 (20%)
		leucine-rich repeat	817..840	CDD:275380	7/23 (30%)
		leucine-rich repeat	845..872	CDD:275380	5/26 (19%)
		leucine-rich repeat	873..900	CDD:275380	6/26 (23%)
		leucine-rich repeat	901..928	CDD:275380	6/45 (13%)
		leucine-rich repeat	929..949	CDD:275380	4/19 (21%)
		leucine-rich repeat	957..977	CDD:275380	1/1 (100%)
		leucine-rich repeat	985..1012	CDD:275380
		leucine-rich repeat	1013..1047	CDD:275380
		leucine-rich repeat	1048..1075	CDD:275380
		leucine-rich repeat	1076..1095	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810