DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7886 and Lrrc45

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_705773.2	Gene:	Lrrc45 / 217366	MGIID:	2387183	Length:	670	Species:	Mus musculus

Alignment Length:	787	Identity:	150/787 - (19%)
Similarity:	289/787 - (36%)	Gaps:	197/787 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FHFRYLELCRAKNLTPVPEIRSKSNATTT-FLELCGDKLAVSDWQLLTEALHYDLVLQQLVVRLR 104
            |...|..||......|...:..:.:.... .|:|....|.|...:.|.:.||.:.:|::||:.
Mouse     4 FRRSYNRLCEESGAEPQEAVLQQLHQLPKGGLDLTTQSLTVETCRALGKLLHKETLLKELVLS-- 66

  Fly   105 RTYPQTNIDPIDTEKRARLFRQRPVIYTRFIFNSLVQAIANCVSSNKNLSVLKLEGLPLQDGYIE 169
                    |.:.:|:.:.|           :|..|      |  :|.::..|.|:|..|:....|
Mouse    67 --------DCMLSEEGSTL-----------LFQGL------C--ANTSVQHLDLKGNNLRATGAE 104

  Fly   170 TIAKALADNECLESVSFRKSNIG--DKGCEVVCNTAKYLNRIEVFDLSECGLTSKGAEHVADMLK 232
            .:.|.|..|:.::|::...:|:|  :......|......:.:...||....::.||||.:|..||
Mouse   105 ALGKLLRQNKSIQSLTLEWNNLGTWEDAFATFCGGLAANSALRQLDLRNNQISHKGAEELALALK 169

  Fly   233 ----MQKITRFTEGWEKSLRYRSVDVNTIGGLRTVLLADNPEIGDVGIRWITEVLKEDAWIKKID 293
                :|::         .||:.:                   ||.:|.|.:...|..:..:.|:|
Mouse   170 GNTTLQQL---------DLRWNN-------------------IGLLGGRALVNCLPSNRTLWKLD 206

  Fly   294 MEGCGLTDIGANLILDCLELN-TAITEFNVRNNEGISKFLQRSIHDRLGCLPEEKQEPEYDLSCV 357
            :.|..:.......:...::.| ..:|.|  |.|:..:|.|.:.:..    |.|||.:...||
Mouse   207 LAGNNIPGDILRAVEQAMDHNQDRLTAF--RENQARTKILSKEVQH----LQEEKSKQFLDL--- 262

  Fly   358 NGLQSLPKNKK----------VTVSQLLSHTKALEEQLSFERTLRKKAEKLNE--KLSHQLMRPD 410
              ::::.|.::          |.|.||   .:||.|:.|....|:.|.:....  .||.|.:|..
Mouse   263 --METIDKQREEMARDSRASAVRVGQL---QEALNERQSIINALKAKLQMTEAALALSEQKVRDL 322

  Fly   411 SNHMVQEKAMEGGSQTNISREYVARNDVMPEVIKNSQSYRQSHFNRLVNSAATSPEVTPRSEIVT 475
            ...:|      .|.|...|..  .|::...::.:...:.|:|...|.: |||:...:..||::..
Mouse   323 GELLV------AGDQERQSLS--QRHEKERKLERQEAADRESKLLRDL-SAASEKNLLLRSQVDE 378

  Fly   476 LRKEQQLQRQQ--PPPMEVKHLSLEQQIRNLRDVQKKVDLDVEEEEEEEEEEQQAEESQSESEPQ 538
            |.::.:.|::|  ....|:.:.|.|.:|   |.:|.:..||||:...::..|...:....|.:..
Mouse   379 LERKARSQQEQLFLTKQELTNTSAELKI---RAIQAEERLDVEKRRAKQNMEDLEKLHSKEVDHM 440

  Fly   539 NEEQQHYEQQMQVQRKHLQVRKVRSEIKYVENNPKEAAKKNRESKSDHEFANERDFKLNPSVQFE 603
            ....:..|:.||.:.:.|:..::..|   .|.:..:||..:...:::.|....|
Mouse   441 TRHLEESERAMQERVQRLEALRLSLE---EELSRMKAAVLSERGQAEEELIKAR----------- 491

  Fly   604 TDIGDNVMVNPGHRYEGGGGDTAYVYNYEHEQQQQPVKRGYEHGYVVGVGDGSHRRQRQSQLVEA 668
                :...:...||.                                     :|..::...|.:|
Mouse   492 ----NQARLEEQHRL-------------------------------------AHLEEKIRLLAQA 515

  Fly   669 --------LVQKRVPGASDGHVAQFVSNLERQANAGKTGKKRLKPRPED---------------- 709
                    :.||::...|...|:|....:|.|       ::||:...::
Mouse   516 RDEAQGTCVQQKQMVAESQARVSQLNLQMEGQ-------QRRLEELQQELINKDQEKVAEVARVR 573

  Fly   710 -DLQVPVGDMHMESSYMSRSEELSSTDVTLEN--SDYETEATDSTLLSSSKYSSMHVFVRRKQSE 771
             :||..:|.|..:   :...|.|......||.  ....:|..::.|...|:.:|:...:|.|::|
Mouse   574 VELQEQMGRMQAD---LVAQEALREKVAALERQMKVIGSEHREALLDRESENASLREKLRLKEAE 635

  Fly   772 SMSLTEE 778
            ...:.:|
Mouse   636 ISRIRDE 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	36/184 (20%)
		leucine-rich repeat	153..180	CDD:275381	8/26 (31%)
		leucine-rich repeat	181..208	CDD:275381	4/28 (14%)
		leucine-rich repeat	209..246	CDD:275381	10/40 (25%)
		leucine-rich repeat	260..285	CDD:275381	5/24 (21%)
Lrrc45	NP_705773.2	leucine-rich repeat	30..55	CDD:275380	5/24 (21%)
		LRR_RI	<35..229	CDD:393385	50/250 (20%)
		LRR 1	59..79		6/40 (15%)
		leucine-rich repeat	60..87	CDD:275380	10/55 (18%)
		LRR 2	87..108		5/20 (25%)
		leucine-rich repeat	88..115	CDD:275380	8/26 (31%)
		LRR 3	115..136		3/20 (15%)
		leucine-rich repeat	116..145	CDD:275380	4/28 (14%)
		LRR 4	145..166		6/20 (30%)
		leucine-rich repeat	146..173	CDD:275380	9/26 (35%)
		LRR 5	173..194		7/48 (15%)
		leucine-rich repeat	174..201	CDD:275380	8/54 (15%)
		LRR 6	201..223		3/21 (14%)
		SMC_prok_B	<267..608	CDD:274008	75/420 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..352		2/21 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900