DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7886 and Nlrp4b

DIOPT Version :9

Sequence 1:NP_650378.1 Gene:CG7886 / 41775 FlyBaseID:FBgn0038248 Length:818 Species:Drosophila melanogaster
Sequence 2:NP_001342080.1 Gene:Nlrp4b / 210045 MGIID:3056570 Length:863 Species:Mus musculus


Alignment Length:265 Identity:51/265 - (19%)
Similarity:102/265 - (38%) Gaps:76/265 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 NKNLSVLKLEGLPLQDGYIETIAKALADNEC---------------------------LESVSFR 187
            ||::..|::|.....:...:.....|.::.|                           ||.:..|
Mouse   628 NKDIKTLRIEDTIFNEPVFKIFYSYLKNSSCILKTLVAYNVSFLCDKRLFLELIQSYNLEELYLR 692

  Fly   188 KSNIGDKGCEVVCNTAKYLNR----IEVFDLSECGLTSKGAEHVADMLKMQKITRFTEGWEKSLR 248
            .:.:.....|::|:   .||:    |.:.||:.|.|.....::::|:|:.          .||||
Mouse   693 GTFLSHSDVEMLCD---ILNQAECNIRILDLANCSLCEHSWDYLSDVLRQ----------NKSLR 744

  Fly   249 YRSVDVNTIGGLRTVLLADNPEIGDVGIRWITEVLK-EDAWIKKIDMEGCGLTDIGANLILDCLE 312
            |.::..|              .:.|.|::.:...|. .::.:..:.:|.|.||  ||    .|.:
Mouse   745 YLNISYN--------------NLKDEGLKALCRALTLPNSALHSLSLEACQLT--GA----CCKD 789

  Fly   313 LNTAITEFN-------VRNNEGISKF--LQRSIHDRLGCLPEEK-QEPEYDLSCVNGLQS-LPKN 366
            |.:..|.:.       .:|:.|.|..  |.:::.|:...|.|.| :..::|......|.| :.:|
Mouse   790 LASTFTRYKCLRRINLAKNSLGFSGLFVLCKAMKDQTCTLYELKLRMADFDSDSQEFLLSEMERN 854

  Fly   367 KKVTV 371
            |.:::
Mouse   855 KILSI 859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7886NP_650378.1 LRR_RI <142..320 CDD:238064 38/201 (19%)
leucine-rich repeat 153..180 CDD:275381 3/26 (12%)
leucine-rich repeat 181..208 CDD:275381 6/26 (23%)
leucine-rich repeat 209..246 CDD:275381 7/36 (19%)
leucine-rich repeat 260..285 CDD:275381 3/25 (12%)
Nlrp4bNP_001342080.1 Pyrin_NALPs 10..93 CDD:260032
NACHT 145..311 CDD:310381
LRR_RI 601..834 CDD:330982 45/238 (19%)
LRR 1 618..643 4/14 (29%)
LRR 2 683..706 4/22 (18%)
leucine-rich repeat 686..709 CDD:275380 5/25 (20%)
leucine-rich repeat 715..742 CDD:275380 7/36 (19%)
LRR 3 717..740 6/32 (19%)
LRR 4 741..763 8/35 (23%)
LRR 5 765..782 3/16 (19%)
leucine-rich repeat 772..799 CDD:275380 9/32 (28%)
LRR 6 797..824 4/26 (15%)
leucine-rich repeat 800..821 CDD:275380 4/20 (20%)
LRR 7 843..863 4/17 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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