DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7886 and Cep78

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_932136.2	Gene:	Cep78 / 208518	MGIID:	1924386	Length:	790	Species:	Mus musculus

Alignment Length:	849	Identity:	187/849 - (22%)
Similarity:	323/849 - (38%)	Gaps:	204/849 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 HFRYLELCRAKNLTPVPEIRSKSNATTTFLELCGDKLAVSDWQLLTEALHYDLVLQQLVVRLRRT 106
            |:.|  ||..::..|:|.:|  :......|:...|:|...||..|...|           |:.|.
Mouse    18 HYEY--LCALQDSVPLPAVR--ACLRDGVLDFNADRLRAVDWAPLLSTL-----------RVNRD 67

  Fly   107 YP----QTNIDP-----------IDTEKRARLFRQR-PVIYTRFIFNSLVQAIANCVSSNKNLSV 155
            .|    :::..|           .||.   |:.|.| |.:.::.|...|.:|:..|:|.:..|..
Mouse    68 LPLVAIKSSFQPWLGETVLRSGGADTH---RICRNRVPAVRSKDISFQLCKALRGCLSVSGVLRN 129

  Fly   156 LKLEGLPLQDGYIETIAKALADNECLESVSFRKSNIGDKGCEVVCNTAKYLNRIEVFDLSECGLT 220
            |:|.||.|::..:.::.|.|:.:..|..:|.....|||.|.|::|...|....::..:.:.|.||
Mouse   130 LELNGLILRERDLTSLTKGLSKSTSLVHLSLANCPIGDGGLEIICQGIKNSVTLKTVNFTGCNLT 194

  Fly   221 SKGAEHVADMLKMQKITRFTEGWEKSLRYRSVDVNTIGGLRTVLLADNPEIGDVGIRWITEVLKE 285
            .:||.|:|.:||.|.:.|..|.|.:|||||..|::.:.|||.:.|..|..|||.|.....:.|.|
Mouse   195 WQGACHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDQGASAFADSLSE 259

  Fly   286 DAWIKKIDMEGCGLTDIGANLILDCLELNTAITEFNVRNNEGISKFLQRSIHDRLGCLPEEKQEP 350
            |.|::.:|::.||||..||..:|:.||.|..:...::|.|..|...:.:::..::
Mouse   260 DLWLRALDLQQCGLTSEGAKALLEALETNRTLVVLDIRKNPLIDHSMMKAVIKKV---------- 314

  Fly   351 EYDLSCVNGLQSLPKNKKVTVSQLLSHTKALEEQLSFERTL---RKKAEKLNEKLSHQLMRPDSN 412
                 ..||..:..:.:.||.......:|..:::   ::|:   ..:..|...::.....:|.||
Mouse   315 -----LQNGRSADSEYQWVTSPSSKEPSKTAKQR---KKTIVLGSSRKGKATIRIGLATKKPSSN 371

  Fly   413 HMVQEKAMEGGSQTNISREYVARNDVMP-----------EVIKNSQS------------YRQSHF 454
                      |.:..:.::..|.|.:.|           |..|.|:|            .::|.|
Mouse   372 ----------GRKQGLGKDCYAPNPLPPGASGFLPWRTAERAKRSRSSSLIKTRDLSNHLKKSDF 426

  Fly   455 NRLVN----SAATSPEVTPRSEIV------TLRKEQQLQRQQPPPMEVKHLSLEQQIRNLRD--- 506
            ...|.    |::.:.|....||.|      |..||:.||.:           ||:.:|.|::
Mouse   427 PVTVTVESPSSSETDETEDSSESVQEAPQKTSIKEETLQEK-----------LEECLRQLKEERV 480

  Fly   507 VQKKVDLDVEEEEEEEEEEQQAEESQSES-EPQNEEQQ---------HYEQQMQVQRKHLQVRK- 560
            ::.|.|..|.|.|.|..:.:....|.||: ..|:....         ..|...|.....|.:.|
Mouse   481 IRLKADKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLKD 545

  Fly   561 --------------------VRSEIKYVENNPKEAAKKNRESKSDHEFANERDFKLNP------- 598
                                .|.::....|.|.:..|           |.| |..|:|
Mouse   546 AGLGQLATMAGIDQSDFHLLGRPQMNSTVNTPIQEQK-----------ALE-DETLHPKQTATGQ 598

  Fly   599 --SVQFETDIGD-------NVMVNPGHRYEGGGGDTAYVYNYEHEQQQQPVKRGYEHGYVV---- 650
              .::|:....|       |.:.:|....|..|....::.....|||:     |...|::.
Mouse   599 MQDIRFQKITSDALIPLPLNTVQDPASAQEAVGASRDHLGVVGLEQQE-----GSAAGFIAKTGS 658

  Fly   651 ----GVGDGSHRRQRQSQLVE------------ALVQKRVPGASDGHVAQFVSNLERQANAGKTG 699
                |:..|  |.||:.:::.            |....|.|.|........:|:.:...|:...|
Mouse   659 PLAGGIPGG--RSQREEEVLSKHSRSSSEKGSTASEPSRRPSAERHPRKDLLSDADPPGNSESKG 721

  Fly   700 ---KKRL--KPRPEDDLQVPVGDMHMESSYMSRSEELSSTDVTLENSDYETEATDSTLLSSSKYS 759
               ::.|  :|...:.|:..:............|:.:.|....||:|:.:|..:|.. |....:|
Mouse   722 PGDRRSLLNEPIKSESLKKCISIKKENRIVTVSSKTIKSKPNLLEHSESDTLGSDFE-LQERVHS 785

  Fly   760 SMHV 763
            |.|:
Mouse   786 SAHL 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	63/177 (36%)
		leucine-rich repeat	153..180	CDD:275381	8/26 (31%)
		leucine-rich repeat	181..208	CDD:275381	9/26 (35%)
		leucine-rich repeat	209..246	CDD:275381	13/36 (36%)
		leucine-rich repeat	260..285	CDD:275381	9/24 (38%)
Cep78	NP_932136.2	LRR_RI	<113..299	CDD:238064	65/185 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..345		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..385		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..462		8/33 (24%)
		GrpE	431..>498	CDD:295646	20/77 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..732		13/79 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	756..790		10/35 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006566
OrthoInspector	1	1.000	-	-		oto95060
orthoMCL	1	0.900	-	-		OOG6_106357
Panther	1	1.100	-	-	LDO	PTHR24110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4507
SonicParanoid	1	1.000	-	-		X5564
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.730