DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7886 and LRRC45

DIOPT Version :9

Sequence 1:	NP_650378.1	Gene:	CG7886 / 41775	FlyBaseID:	FBgn0038248	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_659436.1	Gene:	LRRC45 / 201255	HGNCID:	28302	Length:	670	Species:	Homo sapiens

Alignment Length:	794	Identity:	141/794 - (17%)
Similarity:	281/794 - (35%)	Gaps:	211/794 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FHFRYLELCRAKNLTP----------VPEIRSKSNATTTFLELCGDKLAVSDWQLLTEALHYDLV 95
            |...|..|||.....|          :|..|         |:|....|.|...:.|.:.|..:.:
Human     4 FRRSYSRLCRESGAEPQEAVLQQLHQLPRGR---------LDLATQSLTVETCRALGKLLPRETL 59

  Fly    96 LQQLVVRLRRTYPQTNIDPIDTEKRARLFRQRPVIYTRFIFNSLVQAIANCVSSNKNLSVLKLEG 160
            ..:||:.          |.:.:|:.|.|               |::.:.    :|..|..|.|:|
Human    60 CTELVLS----------DCMLSEEGATL---------------LLRGLC----ANTVLRFLDLKG 95

  Fly   161 LPLQDGYIETIAKALADNECLESVSFRKSNIG--DKGCEVVCNTAKYLNRIEVFDLSECGLTSKG 223
            ..|:....|.:.|.|..|:.::|::...:::|  |......|........::..||....::.||
Human    96 NNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKG 160

  Fly   224 AEHVADMLKMQKITRFTEGWEKSLRYRSVDVNTIGGLRTVLLADNPEIGDVGIRWITEVLKEDAW 288
            ||.:|..||                                  .|..:..:.:||
Human   161 AEELALALK----------------------------------GNTTLQQLDLRW---------- 181

  Fly   289 IKKIDMEGCGLTDIGANLILDCLELNTAITEFNVRNNEGISKFLQRSIHDRLG------------ 341
                  ...||  :|...:::||..|..:...::..| .|...:.|::...:|
Human   182 ------NNVGL--LGGRALMNCLPSNRTLWRLDLAGN-NIPGDVLRAVEQAMGHSQDRLTTFQEN 237

  Fly   342 ------------CLPEEKQEPEYDL--SCVNGLQSLPKNKKVTVSQLLSHTKALEEQLSFERTLR 392
                        .|.|||.:...||  :.....:.:.|:.:.:.:::....:||.|:.|....|:
Human   238 QARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALK 302

  Fly   393 KKAEKLNEKLSHQLMRPDSNHMVQEKAME-GGSQTNISREYVARNDVMPEVIKNSQSYRQSHFNR 456
            .|.:.....|:          :.::||.: |.......:|.::.:....:.:|..|.......::
Human   303 AKLQMTEAALA----------LSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESK 357

  Fly   457 LVN--SAATSPEVTPRSEIVTLRKEQQLQRQQ--PPPMEVKHLSLEQQIRNLRDVQKKVDLDVEE 517
            |:.  |||....:..::::..|.::.:.|::|  ....|:..:|.|.::|           .::.
Human   358 LLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMR-----------AIQA 411

  Fly   518 EEEEEEEEQQAEESQSESEP-QNEEQQHYEQQMQVQRKHLQVRKVRSEIKYVENNPKEAAKKNRE 581
            ||..:.|:::..:|..:||. :.:|.:|..:.::...|.:|.|..|.|...: :..:|.::....
Human   412 EERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARL-SLEEELSRVKAA 475

  Fly   582 SKSDHEFANERDFKLNPSVQFE-----TDIGDNVMVNPGHRYEGGGGDTAYVYNYEHEQQQQPVK 641
            :.|:...|.|...|.....:.|     ..:.|.:.:....|.|..|...         ||:|.|.
Human   476 ALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACL---------QQKQVVA 531

  Fly   642 RGYEHGYVVGVG-DGSHRRQRQSQLVEALVQKRVPGASDGHVAQFVSNLERQANAGKTGKKRLKP 705
            ........:|:. :|..||      :|.|.|:              .:|:.|....:..:.|:
Human   532 EAQTRVSQLGLQVEGLRRR------LEELQQE--------------LSLKDQERVAEVSRVRV-- 574

  Fly   706 RPEDDLQVPVGDMHMESSYMSRSEELSSTDVTLEN------SDYETEATDSTLLSSSKYSSMHVF 764
                :||...|.:..|   ::..|.|......||.      ||:.    ::.|...|:.:|:...
Human   575 ----ELQEQNGRLQAE---LAAQEALREKAAALERQLKVMASDHR----EALLDRESENASLREK 628

  Fly   765 VRRKQSESMSLTEE 778
            :|.:::|...:.:|
Human   629 LRLREAEIARIRDE 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7886	NP_650378.1	LRR_RI	<142..320	CDD:238064	32/179 (18%)
		leucine-rich repeat	153..180	CDD:275381	9/26 (35%)
		leucine-rich repeat	181..208	CDD:275381	4/28 (14%)
		leucine-rich repeat	209..246	CDD:275381	9/36 (25%)
		leucine-rich repeat	260..285	CDD:275381	3/24 (13%)
LRRC45	NP_659436.1	LRR_RI	<34..224	CDD:330982	49/280 (18%)
		leucine-rich repeat	35..59	CDD:275380	6/23 (26%)
		LRR 1	58..80		7/46 (15%)
		leucine-rich repeat	61..84	CDD:275380	7/51 (14%)
		LRR 2	87..107		6/19 (32%)
		leucine-rich repeat	88..115	CDD:275380	9/26 (35%)
		LRR 3	115..136		3/20 (15%)
		leucine-rich repeat	116..145	CDD:275380	4/28 (14%)
		LRR 4	145..166		6/20 (30%)
		leucine-rich repeat	146..173	CDD:275380	10/60 (17%)
		LRR 5	173..194		5/38 (13%)
		leucine-rich repeat	174..201	CDD:275380	8/44 (18%)
		LRR 6	201..212		1/11 (9%)
		SMC_N	267..>634	CDD:330553	76/430 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900