DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad88C and CELSR1

DIOPT Version :10

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:NP_001365257.1 Gene:CELSR1 / 9620 HGNCID:1850 Length:3019 Species:Homo sapiens


Alignment Length:1267 Identity:332/1267 - (26%)
Similarity:526/1267 - (41%) Gaps:296/1267 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   621 FPQRQYETKLLENQAEFETPLQLEARDADLNGTENSQVTYEIVEGLY----RSNFTIDPQSGLLR 681
            ||...|:..|.||:......|||.|. ..:.| |..:|:| .:|||:    |..|.||..:|   
Human   245 FPMPNYQVALFENEPAGTLILQLHAH-YTIEG-EEERVSY-YMEGLFDERSRGYFRIDSATG--- 303

  Fly   682 PVHSFDFEELVDGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIF 746
               :...:.::|..::.:..            |.|:|.|...|..|....:.:.|:|.||::|:|
Human   304 ---AVSTDSVLDRETKETHV------------LRVKAVDYSTPPRSATTYITVLVKDTNDHSPVF 353

  Fly   747 QQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPNNVVVYRIQTGAGDKFIINSETGVISVAHGANL 811
            :||.|.:.|.|:|..|..||.:.|.||| |..|..:.||:..||.|.|.:|..:||:|..  |.|
Human   354 EQSEYRERVRENLEVGYEVLTIRASDRD-SPINANLRYRVLGGAWDVFQLNESSGVVSTR--AVL 415

  Fly   812 DPDLTESKRSLYTLSVIALDGGLGNSQLMTTCTVNISIQDVNNKPPVLKEMP-ALQILENTPVGT 875
            |    ..:.:.|.|.|.|.|.|.....|..|.||.|.::|.|:..|...|.. .:|:.|:..:.|
Human   416 D----REEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476

  Fly   876 LVYRIQATDLD--HKAILRYKLNPEHCEGRTEEGALVKSSEYDFLGAFEVDSIEGTLKVVKLLDR 938
            .|.|:||||.|  ..|.:.|.:...:..|:                 |.:.|:.|.|.|:..||.
Human   477 AVLRVQATDRDQGQNAAIHYSILSGNVAGQ-----------------FYLHSLSGILDVINPLDF 524

  Fly   939 ERVEHIKLAITVEDLAAAKGRQ---IAEGFLSIQVLDENDNNPKFRLPFYRQSITENSINGAMIV 1000
            |.|:...|:|..:|    .||.   .:.|.:|:||||.|||.|.|....::.::.||...|..:|
Human   525 EDVQKYSLSIKAQD----GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVV 585

  Fly  1001 NVLASDVD--KNRTITYALEGN----------------PTYRSLMHLDPQTGEIVVASKIDHEQH 1047
            ::.|.|.|  :|..:.|.|...                ||......:...:|.|.|.:::|.|:.
Human   586 HIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEV 650

  Fly  1048 QWLNFSVRATDSGIPARSSLVDVYITVLDENDNNPYFVGGSKNYTISENAAPGTRVATLQAGDAD 1112
            :..:|.|.|.|.|.|..||...|.|||||.|||:|.|...:....::|:||.|:.|.||||.|.|
Human   651 EHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD 715

  Fly  1113 SGDFGKITFLMDRISSQGKFTIDADT--GVLTVADRLDRESKDSYNLVIEAWDNYQFGFLAGESR 1175
            :...  ||:.:...:::.:|.:.:..  |::|:|..||.:.:..|.|.:.|.|.         :|
Human   716 ANSV--ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG---------TR 769

  Fly  1176 NAFKQVFISILDENDNPPEVDLPMSCVLITEYHELHERVASIVGKDADDPTTPNGRLDFAITRGN 1240
            :....|.|::.|.|.:.|........|.::|...:...:|::...|.|  |..|.|:.:.|    
Human   770 SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDED--TGENARITYVI---- 828

  Fly  1241 KDGMFELRQIDAWNAQIFASKSLRNRYGN---YSLTITTRDMGLPANIVHNTLDICVSDFNDHAP 1302
            :|.:.:.| ||..:..::....|  .|.|   |:|||..:|.|:|......||:|.:.|.||:||
Human   829 QDPVPQFR-IDPDSGTMYTMMEL--DYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAP 890

  Fly  1303 VFVRPLHNTTVRIPENATVGTLILQAYASDGDMGQNALVRYRLKPDPLGSYKMFEVDGSTGELFL 1367
            .|:...:..:  |.|:|...|.|||..|:|.|.|.|..:.|..:....|... |.::.::|.:..
Human   891 QFLWDFYQGS--IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGD-FYIEPTSGVIRT 952

  Fly  1368 KEQLNREKQKIHEIRIEAYDQGLPTSLSSDLDLTIYVRNVNDYEPQFMVNEISVNFTEHSDP-GS 1431
            :.:|:||...::.:...|.|:|.||.||:.:::.:.:.::||..|.|..:|:.: |.|.::| ||
Human   953 QRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELEL-FVEENNPVGS 1016

  Fly  1432 ERIKLPDTIDKDQLELDDPNDTP-SQVCYFIVNGNEAGYFRLDPETHILTVDRELDREVIANFTL 1495
            ...|         :..:||::.| :|:.|.||.|:...:|:||.....|....|||.||...:.|
Human  1017 VVAK---------IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVL 1072

  Fly  1496 YVRATENCRNDSISGGEKRRRMGIEINNRLGGIVHNQQFGYDRFKHSRQLRSTESNEYGPEDAEL 1560
            .|:||                                                        .|.|
Human  1073 VVQAT--------------------------------------------------------SAPL 1081

  Fly  1561 LSYEAYDSSQEDPTGGLATTHPELDSTVIKVKVRVLDINDNPPRF-------------RSKIFTG 1612
            :|              .||.|           :.::|.|||||..             :|..|..
Human  1082 VS--------------RATVH-----------ILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121

  Fly  1613 GITTNADFGLKFMRVEATDADEGDNGRIGYYQVGEIRQTLSEGLENVRKAPFLLDQETGEVQL-- 1675
            |:     .|.    :.|.|.|..|:....:.|..|:|.             .|||..|||:||  
Human  1122 GV-----IGC----IPAHDPDVSDSLNYTFVQGNELRL-------------LLLDPATGELQLSR 1164

  Fly  1676 NFDPQKGMKGYFDFVVLANDTSGMKDVAHVFIYLLREDQKVRFVFRLQPDELRSRVDSFRDTL-- 1738
            :.|..:.::...:..|    :.|:..|. .|..|                    ||....|.:  
Human  1165 DLDNNRPLEALMEVSV----SDGIHSVT-AFCTL--------------------RVTIITDDMLT 1204

  Fly  1739 SNITESIVNIDEIK--------VHENKDGSVDKTKTDLYMHLVEREDNSIYEVSEVLKLIDSHIE 1795
            ::||..:.|:.:.|        ..|.....:..||.|:::..|:.:.:           :.|:| 
Human  1205 NSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTD-----------VSSNI- 1257

  Fly  1796 SLNGLFKELNVLDTQAAEAQLLTAGPSRGPLF 1827
                    |||  |.:|    |..|..||..|
Human  1258 --------LNV--TFSA----LLPGGVRGQFF 1275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637
Cadherin_repeat 179..276 CDD:206637
Cadherin_repeat 287..388 CDD:206637
Cadherin_repeat 397..506 CDD:206637
Cadherin_repeat 514..617 CDD:206637
Cadherin_repeat 625..742 CDD:206637 30/120 (25%)
Cadherin_repeat 751..853 CDD:206637 38/101 (38%)
Cadherin_repeat 865..976 CDD:206637 34/115 (30%)
Cadherin_repeat 985..1080 CDD:206637 32/112 (29%)
Cadherin_repeat 1090..1191 CDD:206637 28/102 (27%)
CA 1221..1302 CDD:214520 26/83 (31%)
Cadherin_repeat 1312..1409 CDD:206637 26/96 (27%)
Cadherin_repeat 1418..>1502 CDD:206637 28/85 (33%)
Cadherin_repeat 1617..1710 CDD:206637 21/94 (22%)
CELSR1NP_001365257.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..242
Cadherin_repeat 250..349 CDD:206637 30/119 (25%)
Cadherin_repeat 357..455 CDD:206637 39/104 (38%)
Cadherin_repeat 464..561 CDD:206637 34/117 (29%)
Cadherin_repeat 569..683 CDD:206637 32/113 (28%)
Cadherin_repeat 691..785 CDD:206637 28/104 (27%)
Cadherin_repeat 793..888 CDD:206637 28/103 (27%)
Cadherin_repeat 897..995 CDD:206637 27/100 (27%)
Cadherin_repeat 1003..1097 CDD:206637 36/184 (20%)
Cadherin_repeat 1117..1198 CDD:206637 26/127 (20%)
EGF_CA 1364..1399 CDD:238011
EGF_CA 1407..1441 CDD:238011
LamG 1444..1627 CDD:238058
EGF_CA 1651..1685 CDD:238011
Laminin_G_2 1719..1849 CDD:460494
EGF_CA 1874..1908 CDD:238011
TNFRSF 1881..2011 CDD:473981
CRD2 1898..1934 CDD:276930
EGF_Lam 2002..>2040 CDD:238012
HormR 2052..2113 CDD:214468
GAIN 2130..2381 CDD:465137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2291..2328
GPS 2407..2460 CDD:197639
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 2411..2461
7tm_GPCRs 2465..2718 CDD:475119
TM helix 1 2468..2492 CDD:320657
TM helix 2 2501..2522 CDD:320657
TM helix 3 2532..2554 CDD:320657
TM helix 4 2573..2589 CDD:320657
TM helix 5 2608..2631 CDD:320657
TM helix 6 2654..2676 CDD:320657
TM helix 7 2680..2705 CDD:320657
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2777..2939
Blue background indicates that the domain is not in the aligned region.

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