DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad88C and CDHR1

DIOPT Version :9

Sequence 1:	NP_731930.3	Gene:	Cad88C / 41774	FlyBaseID:	FBgn0038247	Length:	1981	Species:	Drosophila melanogaster
Sequence 2:	XP_011538639.1	Gene:	CDHR1 / 92211	HGNCID:	14550	Length:	917	Species:	Homo sapiens

Alignment Length:	908	Identity:	256/908 - (28%)
Similarity:	405/908 - (44%)	Gaps:	192/908 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SNRPPRFAID--GQSEIVLRLKESPE-TKVGTLIYTLKGYDPDNDPLTFGKRNSHDS------EI 110
            :|..|.|..:  |.:...:.|...|| |.||:.:|||.|.||:.||:::     |.|      .:
Human    79 ANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISY-----HISFDPSTRSV 138

  Fly   111 IRIENTGGNEAKIFLAKELDRELQDEYAIVLTLTDSHYSDHNYVTQSFLLLVEDINDNVPTFL-- 173
            ..::.|.||   |.|.:|||||.:||...:::::|.    .|.|.:..::||.|.||..|.|:
Human   139 FSVDPTFGN---ITLVEELDREREDEIEAIISISDG----LNLVAEKVVILVTDANDEAPRFIQE 196

  Fly   174 PYQNAI--EIPEGSAPGVVSTLEATDADEGAYGQVVYYLQELDGDNDVFSIATHQGKGILRLQ-- 234
            ||...:  :||.||   ::..:.|.|.|.|:.|.|.|:||.|   :..|::..|  .|:||||
Human   197 PYVALVPEDIPAGS---IIFKVHAVDRDTGSGGSVTYFLQNL---HSPFAVDRH--SGVLRLQAG 253

  Fly   235 KELDYERKSLYQLRVLAIDRANQ----GPINTGTAAILVKVKDLEDQPPEFVEVQAVARIAEDAP 295
            ..|||||...:.:.|:|.|...:    ..:.:.|..:.|.|:|::|..|.||.......:.||..
Human   254 ATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTL 318

  Fly   296 VGTKVLRVRAIDGDRGINNPIAYSL-EAND-LFDINPHTG---IVHTLTKLDREEQSDQVNGAHI 355
            .|::||:|.|:|||||..|.|.||| ..|| .|:||..:|   |..:..:|.||        .:.
Human   319 PGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQRE--------VYE 375

  Fly   356 LRISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPTF-GET--VYRCEVNENAQTNTPLNFIDE 417
            |.:..||:|.:.:..|..||  .||:.:.|:|:..||| ||:  ..|.|::.|  .:.|...|..
Human   376 LHVQVTEMSPAGSPAAQATV--PVTIRIVDLNNHPPTFYGESGPQNRFELSMN--EHPPQGEILR 436

  Fly   418 EVQNVVFDHDEGNNGTFRLFLDPPNDLFEIVPELAVNEANFMLRVKNSKSLDFEQFTEVNFTIFA 482
            .::..|.|.|:|.|..|.|.|..|..:|.:||:..:|||...:.|:||.::|||:...:.|.:.|
Human   437 GLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA 501

  Fly   483 REVDEPSRWSS-AHVQIFIRDQNDNFPEFSQTIYNASVLENSEQDTIITHVQAVDVDSGDYGTMG 546
            .||:.|.::|| |.|.|.:.|.|||.|:|....|.|.:.||:...:.:..|.|||.|:|.:|.
Human   502 VEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGE-- 564

  Fly   547 IRYTNLRGGIAHLLNLNPITGVITIKQAGGTAFDREIISRHYLTVEAIDNAGQGNRNTAQIIVDI 611
            ::|:....| |.|..::|.||:|..:.  ..:.|.|..:|:...|:|.|.  :|..:.|::.:.:
Human   565 VKYSTYGTG-ADLFLIHPSTGLIYTQP--WASLDAEATARYNFYVKAEDM--EGKYSVAEVFITL 624

  Fly   612 LDVNDNAPTFPQR-QYETKLLENQAEFETPLQLEARDADLNGTENSQVTYEIVEGLYRSNFTIDP 675
            |||||:.|.|.:. |.:|.:|      .||:::||.|.|.. ..|:.|.|.|...
Human   625 LDVNDHPPQFGKSVQKKTMVL------GTPVKIEAIDEDAE-EPNNLVDYSITHA---------- 672

  Fly   676 QSGLLRPVHSFDFEELVDGSSRRSDPYTGGSF---SIREIDLL--------------VRARDSGI 723
                 .|.:.||.           :.:||..:   |||.:|.|              |:|:|.|.
Human   673 -----EPANVFDI-----------NSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS 721

  Fly   724 PMLSTVVPVLIYVQDVNDNAPIFQQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPNNVVVYRIQT 788
            |..||                                  :::|::...|.:..:.:.:..:.|||
Human   722 PSFST----------------------------------TALLKIDITDAETLSRSPMAAFLIQT 752

  Fly   789 GAGDKFIINSETGVISVAHGANLDPDLTESKRSLYTLSVIALDGGLGNSQLMTTCTVNISIQDVN 853
                                         ....:..:.|:|     |....:...||.||.....
Human   753 -----------------------------KDNPMKAVGVLA-----GTMATVVAITVLISTATFW 783

  Fly   854 NKPPVLKEMPALQILENTP-VGTLVYRIQ-----ATDLDHKAILRYKLNPEHCEGRTEEGALV 910
            ......|.:|..::|...| ......||:     :|....|.:|:.|...|:|...:.|.:|:
Human   784 RNKKSNKVLPMRRVLRKRPSPAPRTIRIEWLKSKSTKAATKFMLKEKPPNENCNNNSPESSLL 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad88C	NP_731930.3	Cadherin_repeat	76..168	CDD:206637	34/98 (35%)
		Cadherin_repeat	179..276	CDD:206637	33/104 (32%)
		Cadherin_repeat	287..388	CDD:206637	37/105 (35%)
		Cadherin_repeat	397..506	CDD:206637	38/109 (35%)
		Cadherin_repeat	514..617	CDD:206637	31/102 (30%)
		Cadherin_repeat	625..742	CDD:206637	30/133 (23%)
		Cadherin_repeat	751..853	CDD:206637	12/101 (12%)
		Cadherin_repeat	865..976	CDD:206637	12/52 (23%)
		Cadherin_repeat	985..1080	CDD:206637
		Cadherin_repeat	1090..1191	CDD:206637
		CA	1221..1302	CDD:214520
		Cadherin_repeat	1312..1409	CDD:206637
		Cadherin_repeat	1418..>1502	CDD:206637
		Cadherin_repeat	1617..1710	CDD:206637
CDHR1	XP_011538639.1	Cadherin_repeat	100..188	CDD:206637	33/99 (33%)
		Cadherin_repeat	197..299	CDD:206637	35/109 (32%)
		Cadherin_repeat	308..407	CDD:206637	38/108 (35%)
		Cadherin_repeat	421..526	CDD:206637	37/106 (35%)
		Cadherin_repeat	535..630	CDD:206637	31/101 (31%)
		Cadherin_repeat	646..737	CDD:206637	28/151 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9086
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010