DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad88C and FAT4

DIOPT Version :9

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:NP_001278232.1 Gene:FAT4 / 79633 HGNCID:23109 Length:4983 Species:Homo sapiens


Alignment Length:1935 Identity:520/1935 - (26%)
Similarity:809/1935 - (41%) Gaps:395/1935 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 VLRLKES--PETKVGTLIYT-LKGYDPDNDPLTFGKRNSHDSEIIRIENTGGNEAKIFLAKELDR 131
            |||:..|  .|...|.:.|: :||    |:...|.           |::|.|   ::.|..:||.
Human  1229 VLRVSASDVDEGNNGLIHYSIIKG----NEERQFA-----------IDSTSG---QVTLIGKLDY 1275

  Fly   132 ELQDEYAIVLTLTDSHYSDHNYVTQSFLLLVEDINDNVPTFLPYQNAIEIPEGSAPG-VVSTLEA 195
            |....|::|:...||.....| .|.:..:.:.|.|||.|:|......:::.|....| :||::.|
Human  1276 EATPAYSLVIQAVDSGTIPLN-STCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTA 1339

  Fly   196 TDADEGAYGQVVYYLQELDGDND--VFSIATHQGKGILRLQKELDYERKSLYQLRVLAIDRANQG 258
            ||:|.|....:.|   .:.|.|:  .|||:.:.|.  :.|.|:||:|.:|||:|.:.|.|:..  
Human  1340 TDSDSGDNADLYY---SITGTNNHGTFSISPNTGS--IFLAKKLDFETQSLYKLNITAKDQGR-- 1397

  Fly   259 PINTGTAAILVKVKDLEDQPPEFVEVQAVARIAEDAPVGTKVLRVRAIDGDRGINNPIAYS---- 319
            |..:.|.::::.|:|..|.||.|........|.|:.|:||.|:.|.|.|.|..||..::|:    
Human  1398 PPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQ 1462

  Fly   320 LEANDLFDINPHTGIVHTLTKLDREEQSDQVNGAHILRISATELSKSNTQMAPTTVR----TEVT 380
            :...:.|.|:...|.::|..::|||       .|::..::.    |:|.|..|...|    ..||
Human  1463 MPRGNHFTIDEVKGTIYTNAEIDRE-------FANLFELTV----KANDQAVPIETRRYALKNVT 1516

  Fly   381 VIVSDVNDEIPTFGETVYRCEVNENAQTNTPLNFIDEEVQNVV-FDHDEGNNGTFRLFLDPPNDL 444
            ::|:|:||.:|.|        :::||....|...|...:..:: .|.|||.||...         
Human  1517 ILVTDLNDNVPMF--------ISQNALAADPSAVIGSVLTTIMAADPDEGANGEIE--------- 1564

  Fly   445 FEIV----PELAVNEANFMLRVKNSKSLDFEQFTEVNFTIFAREVDEPSRWSSAHVQIFIRDQND 505
            :||:    ....|:..:..|||  :.:|...|.. .|..:.|.::....|.|:..:.|.:  |..
Human  1565 YEIINGDTDTFIVDRYSGDLRV--ASALVPSQLI-YNLIVSATDLGPERRKSTTELTIIL--QGL 1624

  Fly   506 NFPEFSQTIYNASVLENSEQDTIITHVQAVDVDSG-------DYGTMGIRYTNLRGGIAHLLNLN 563
            :.|.|:|..| .::|:  |.:.|.|:|.:::..|.       :|..:.:|.....  :..|..:.
Human  1625 DGPVFTQPKY-ITILK--EGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKT--VGRLFTIG 1684

  Fly   564 PITGVITIKQAGGTAFDREIISRHYLT-VEAIDNAGQGNR-NTAQIIVDILDVNDNAPTFPQRQY 626
            ..||:|..    ....|||..:..||. |.||:.:....| ..|::.:.:.|:|||.|.||....
Human  1685 RHTGIIQT----AAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDML 1745

  Fly   627 ETKLLENQAEFETPLQLEARDADLNGTENSQVTYEIVEGLYRSNFTIDPQSGLLRPVHSFDFEEL 691
            :..:.||..:....:||.|.|||...  |:.|||.|:.|. ..:|.|||:||.|......|.|  
Human  1746 DLTVEENIGDGSKIMQLTAMDADEGA--NALVTYTIISGA-DDSFRIDPESGDLIATRRLDRE-- 1805

  Fly   692 VDGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAKTVP 756
                 |||           :..|||||.|.   :.|:.:.:.|.|.||||:.|.|.:..|:..:|
Human  1806 -----RRS-----------KYSLLVRADDG---LQSSDMRINITVSDVNDHTPKFSRPVYSFDIP 1851

  Fly   757 EDLPGGSSVLQVTAIDRDGSAPNNVVVYRIQTGAGDK-FIINSETGVISVAHGANLDPDLTESKR 820
            ||...||.|..:.|.| |.|..|..:.|.:.....|. |.:|..|||.      ||...|....:
Human  1852 EDTIPGSLVAAILATD-DDSGVNGEITYIVNEDDEDGIFFLNPITGVF------NLTRLLDYEVQ 1909

  Fly   821 SLYTLSVIALDGGLGNSQLMTTCTVNISIQDVNNKPPVLK-EMPALQILENTPVGTLVYRIQATD 884
            ..|.|:|.|.||| |.   .||..|..:|.|||:.||:.. ...:..::||.|||:.|.....||
Human  1910 QYYILTVRAEDGG-GQ---FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTD 1970

  Fly   885 LDH--KAILRYKLNPEHCEGRTEEGALVKSSEYDFLGAFEVDSIEGTLKVVKLLDRERVEHIKLA 947
            .|.  .:.|.|.:                 :..|.||.|.||. .|.|||:|.||||......|.
Human  1971 ADDGINSQLTYSI-----------------ASGDSLGQFTVDK-NGVLKVLKALDRESQSFYNLV 2017

  Fly   948 ITVEDL---AAAKGRQIAEGFLSIQVLDENDNNPKFRLPFYRQSITENSINGAMIVNVLASDVDK 1009
            :.|.||   .|::....|:  :||.:||.|||.|.|..|.... |.||:....::....|:|.|.
Human  2018 VQVHDLPQIPASRFTSTAQ--VSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDS 2079

  Fly  1010 --NRTITYALEGNPTYR--SLMHLDPQTGEIVVASKIDHEQHQWLNFSVRATDSGIPARSSLVDV 1070
              |..|.|.|. ||...  |:..:|   ||:.:..::|.|:......:|.|||.|.|:.||..:|
Human  2080 GPNSYIEYTLL-NPLGNKFSIGTID---GEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEV 2140

  Fly  1071 YITVLDENDNNPYFVGGSKNYTISENAAPGTRVATLQAGDADSGDFGKITFLMDRISSQGKFTID 1135
            .:.|||.|||||.|........|:||...||.:..:.|.|.|.|..|::.:.:...::..:|.||
Human  2141 VVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRID 2205

  Fly  1136 ADTGVLTVADRLDRESKDSYNLVIEAWDNYQFGFLAGESRNAFKQVFISILDENDNPPEVDL-PM 1199
            :.||.:|||..||||...:|:|.::|.|.      ....|.....|.|.:||.||..|..:| |.
Human  2206 SVTGAITVAKPLDREKTPTYHLTVQATDR------GSTPRTDTSTVSIVLLDINDFVPVFELSPY 2264

  Fly  1200 SCVLITEYHELHERVASIVGKDADDPTTPNGRLDFAITRGNKDGMFELRQIDAWNAQIFASKSL- 1263
            |..:......|...:..:|.:  ||....|.:|.:.:..||:|..|.|    :.:.::..::|| 
Human  2265 SVNVPENLGTLPRTILQVVAR--DDDRGSNSKLSYVLFGGNEDNAFTL----SASGELGVTQSLD 2323

  Fly  1264 RNRYGNYSLTITTRDMGLPANIVHNTLDICVSDFNDHAPVFVRPLHNTTVRIPENATVGTLILQA 1328
            |.....:.|.||..|.|.||.....|:::.|.|.||:.|.|....:.||  |||:|..||.:|..
Human  2324 RETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTT--IPEDAPTGTDVLLV 2386

  Fly  1329 YASDGDMGQNALVRYRLKPDPLGSYKMFEVDGSTGELFLKEQLNREKQKIHEIRIEAYDQGLPTS 1393
            .|||.|..:||::.||:    :|....|.::.|||::.....|:||.:..:.:.:...|.|.|..
Human  2387 NASDADASKNAVISYRI----IGGNSQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEP 2447

  Fly  1394 LSSDLDLTIYVRNVNDYEPQFM----VNEI----------------------------------- 1419
            |||...:.:.|.:|||..|:|.    |..|                                   
Human  2448 LSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNS 2512

  Fly  1420 ----------------------SVNFTEH-SDPGS--------------ERIKLPDTIDKDQLEL 1447
                                  .|.|:.| .|.||              .:...|....|:|..:
Human  2513 EKFHIDPLRGAIMAAGPLNGASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFM 2577

  Fly  1448 DDPNDTPSQ--------------VCYFIVNGNEAGYFRLDPETHILTVDRELDREVIANFTLYVR 1498
            ...|...|.              :.|:|.:||....|::|..|..:::.:.||.|.|..:.:::.
Human  2578 FPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIE 2642

  Fly  1499 ATENCRNDSISGG-------EKRRRMGIEINNR---------LGGIVHNQQFGYDRFKHSRQLR- 1546
            |.:        ||       ||.....:::|:.         :..|:.|..        .|::. 
Human  2643 ARD--------GGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLS--------PRKILT 2691

  Fly  1547 -STESNEYGPEDAELLSYEAYDSSQED------PTGGLATTHPELD------------------- 1585
             |....:.||...  |.||..:.:.|:      .||.:.:..| ||                   
Human  2692 VSAMDKDSGPNGQ--LDYEIVNGNMENSFSINHATGEIRSVRP-LDREKVSHYVLTIKSSDKGSP 2753

  Fly  1586 --STVIKVKVRVLDINDNPPRFRSKIFTGGITTNADFGLKFMRVEATDADEGDNGRIGYYQVGEI 1648
              ||.:||.:.:||.|||.||| |:||:..:..|:..|....||..:|.|.|.|. |..|.:.: 
Human  2754 SQSTSVKVMINILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDEDIGINA-ISRYSIMD- 2815

  Fly  1649 RQTLSEGLENVRKAPFLLDQETGEVQLNFDPQKGMKGYFDFVVLANDTSGMKDVAHVFIY----- 1708
                       ...||.::..||::.::....:.....:...|.|:| ||......|.|:     
Human  2816 -----------ASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHD-SGWTVSTDVTIFVTDIN 2868

  Fly  1709 -----------------LLREDQKVRFVFRLQPDE---------LRSRVDSFRDTLSNITESIVN 1747
                             |.....||..||...|||         ::|:.:.||  ::..|..|.|
Human  2869 DNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFR--INATTGEIFN 2931

  Fly  1748 IDEIKVHENKDGSVDKTKTDLYMHLVEREDNS----IYEVSEVLKLIDSH 1793
             .:|..::|..| ......:.:..:|...|..    |.|.:..:.::||:
Human  2932 -KQILKYQNVTG-FSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSN 2979

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 23/94 (24%)
Cadherin_repeat 179..276 CDD:206637 31/99 (31%)
Cadherin_repeat 287..388 CDD:206637 30/108 (28%)
Cadherin_repeat 397..506 CDD:206637 24/113 (21%)
Cadherin_repeat 514..617 CDD:206637 25/111 (23%)
Cadherin_repeat 625..742 CDD:206637 38/116 (33%)
Cadherin_repeat 751..853 CDD:206637 35/102 (34%)
Cadherin_repeat 865..976 CDD:206637 37/115 (32%)
Cadherin_repeat 985..1080 CDD:206637 31/98 (32%)
Cadherin_repeat 1090..1191 CDD:206637 32/100 (32%)
CA 1221..1302 CDD:214520 24/81 (30%)
Cadherin_repeat 1312..1409 CDD:206637 32/96 (33%)
Cadherin_repeat 1418..>1502 CDD:206637 24/169 (14%)
Cadherin_repeat 1617..1710 CDD:206637 21/114 (18%)
FAT4NP_001278232.1 Cadherin_repeat 48..131 CDD:206637
Cadherin_repeat 139..246 CDD:206637
Cadherin_repeat 254..349 CDD:206637
Cadherin_repeat 364..471 CDD:206637
Cadherin_repeat 479..577 CDD:206637
Cadherin_repeat 588..685 CDD:206637
Cadherin_repeat 693..789 CDD:206637
Cadherin_repeat 798..889 CDD:206637
Cadherin_repeat 899..992 CDD:206637
Cadherin_repeat 1000..1096 CDD:206637
Cadherin_repeat 1105..1206 CDD:206637
Cadherin_repeat 1215..1311 CDD:206637 26/100 (26%)
Cadherin_repeat 1321..1416 CDD:206637 31/101 (31%)
Cadherin_repeat 1428..1525 CDD:206637 31/107 (29%)
Cadherin_repeat 1540..1622 CDD:206637 20/95 (21%)
Cadherin_repeat 1634..1736 CDD:206637 25/110 (23%)
Cadherin_repeat 1747..1837 CDD:206637 38/113 (34%)
Cadherin_repeat 1845..1940 CDD:206637 37/105 (35%)
Cadherin_repeat 1948..2047 CDD:206637 37/118 (31%)
Cadherin_repeat 2057..2150 CDD:206637 31/97 (32%)
Cadherin_repeat 2159..2254 CDD:206637 31/100 (31%)
Cadherin_repeat 2263..2360 CDD:206637 27/102 (26%)
Cadherin_repeat 2369..2464 CDD:206637 34/100 (34%)
Cadherin_repeat 2472..2559 CDD:206637 8/86 (9%)
Cadherin_repeat 2573..2667 CDD:206637 20/101 (20%)
Cadherin_repeat 2675..2771 CDD:206637 22/106 (21%)
Cadherin_repeat 2778..2870 CDD:206637 23/105 (22%)
Cadherin_repeat 2878..2981 CDD:206637 23/106 (22%)
Cadherin_repeat 2990..3085 CDD:206637
Cadherin_repeat 3095..3192 CDD:206637
Cadherin_repeat 3201..3295 CDD:206637
Cadherin_repeat 3305..3402 CDD:206637
Cadherin_repeat 3410..3508 CDD:206637
Cadherin_repeat 3516..3612 CDD:206637
EGF_CA 3864..3900 CDD:238011
EGF_CA 3902..3938 CDD:238011
EGF_CA 3941..3976 CDD:238011
LamG 3979..4142 CDD:238058
EGF 4168..4198 CDD:278437
LamG 4247..4368 CDD:238058
EGF_CA 4431..4465 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.