DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad88C and Cdhr3

DIOPT Version :9

Sequence 1:	NP_731930.3	Gene:	Cad88C / 41774	FlyBaseID:	FBgn0038247	Length:	1981	Species:	Drosophila melanogaster
Sequence 2:	NP_001019649.1	Gene:	Cdhr3 / 68764	MGIID:	1916014	Length:	831	Species:	Mus musculus

Alignment Length:	723	Identity:	181/723 - (25%)
Similarity:	286/723 - (39%)	Gaps:	142/723 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   859 LKEMPAL-QILENTPVGTLVYRIQATDLDHKAILRYKLNPEHCEGRTEEGALVKSSEYDFLGAFE 922
            |..:||. .:.||.|..|||::....       |...|:|      ...|..:..:...|..||.
Mouse    22 LLHLPATSNVAENAPPATLVHKFSVN-------LSVSLSP------VIPGFPLVVNPRPFTEAFR 73

  Fly   923 VDSIEGT-LKVV----KLLDRER-VEHIKLAITVEDLAAAKGRQIAEGFLSIQVLDENDNNPKFR 981
            |:.:..| .:||    :.||.|| .:...|.|.|:|.......|:    |::||.|.|: .|:|:
Mouse    74 VNRLSATNFEVVTTGKEQLDFERGPKAFDLQIYVKDDVGVTDVQV----LTVQVTDVNE-PPQFQ 133

  Fly   982 ------LPFYRQSITENSINGAMIVNVLASD-VDKNRTI-----------TYALEGNPTYRSLMH 1028
                  |..|   :.|.: |...|..|.|.| .|.:|:|           .:.:..|.|..|...
Mouse   134 GILAQGLNLY---VIERT-NPGFIYQVEAFDPEDTSRSIPLGYFLISPSKNFRMSANGTLFSTTE 194

  Fly  1029 LDPQTGEIVVASKIDHEQHQWLNFSVRATDSG-IPARSSLVDVYITVLDENDNNPYFVGGSKNYT 1092
            ||.:.|            |:..|..|...||| :.|.::|   .:|:::.||..|.|....:.|:
Mouse   195 LDFEAG------------HKSFNLLVGVRDSGNLEASTAL---QVTIVNINDETPRFTSPRRVYS 244

  Fly  1093 ISENAAPGTRVATLQAGDADSGDF-GKITFLMDRISSQGKFTIDADTGVLTVADRLDRESKD--- 1153
            :.|....||.||.:.|.|.|...| |::.:.:...||.  |.:|..||.:.||.||||::.:
Mouse   245 VPEEVPLGTMVANITAMDPDDEGFPGRLLYSITTTSSY--FMVDQLTGTIQVARRLDRDAGELRQ 307

  Fly  1154 --SYNLVIEAWDNYQFGFLAGESRNAFKQVFISILDENDNPPEVDLPMSCVLITEYHELHERVAS 1216
              ..:|.:...|.     .:|...|..:..|| :.|.|||      |.:|..:|....|.||.|:
Mouse   308 NPIISLEVRVRDR-----PSGGQENRMQITFI-VEDINDN------PATCRKLTFSIMLPERTAN 360

  Fly  1217 -----IVGKDA--DDPTTPNGRLDFAITRGNKDGMFELRQIDAWNAQIFASKSL------RNRYG 1268
                 .:.|..  ||...||.:.:|....|..... ...|..|.:.:|..:..|      ....|
Mouse   361 GTLLLDLNKFCFDDDSEAPNNKFNFTTPSGAGSSR-RFSQHPAGSGRIVLTGDLDYENPSNLAVG 424

  Fly  1269 N-YSLTITTRDMGLPANIVHNTLDICVSDFNDHAPVFVRPLHNTTVRIPENATVGTLILQAYASD 1332
            | |::.|..:|...|.......:.|.....|:...:|.||.:  ...:||.....|.|.|..|:|
Mouse   425 NVYNVMIQVQDAAPPYYKKSIYISILTRPENEFPLIFERPSY--VFDVPERRPARTQIGQVRATD 487

  Fly  1333 GDMGQNALVRYRLK--PDPLGSYKMFEVDGSTGELFLKEQLNREKQKIHEIRIEA---YDQGLPT 1392
            .|..:..:| |.:.  ...|....:|.::..||||.|..|.:.|...::.:.:||   .|:
Mouse   488 ADFPRTPVV-YSVSRGGSSLQYPNIFWINPKTGELQLITQADHETTSVYILTVEATNGEDR---- 547

  Fly  1393 SLSSDLDLTIYVRNVNDYE----PQFMVNEISVNFTEHSDPGSERIKLPDTIDKDQLELDDPNDT 1453
               |.:.:|:.:...||.:    |.|....|.|:           :|:...|...:|...|.:.:
Mouse   548 ---SSVTVTVNILGENDEKPVCTPNFYFMAIPVD-----------LKVGTNIQNFKLTCTDLDSS 598

  Fly  1454 PSQVCYFIVNGNEAGYFRLDPE-----THILTVDR----ELDREVIANFTLYVRATENCRNDSIS 1509
            ||...|.|.:||...:|...|.     |.:|...|    .||  .:.::.|.|..|:   ::.:|
Mouse   599 PSSFRYSIGSGNINNHFTFSPNAGSNITRLLLASRFDYSSLD--TVWDYQLLVHITD---DNLLS 658

  Fly  1510 GGEKRRRM 1517
            |..|.:.:
Mouse   659 GSTKAKAL 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad88C	NP_731930.3	Cadherin_repeat	76..168	CDD:206637
		Cadherin_repeat	179..276	CDD:206637
		Cadherin_repeat	287..388	CDD:206637
		Cadherin_repeat	397..506	CDD:206637
		Cadherin_repeat	514..617	CDD:206637
		Cadherin_repeat	625..742	CDD:206637
		Cadherin_repeat	751..853	CDD:206637
		Cadherin_repeat	865..976	CDD:206637	31/117 (26%)
		Cadherin_repeat	985..1080	CDD:206637	26/107 (24%)
		Cadherin_repeat	1090..1191	CDD:206637	31/106 (29%)
		CA	1221..1302	CDD:214520	18/89 (20%)
		Cadherin_repeat	1312..1409	CDD:206637	24/101 (24%)
		Cadherin_repeat	1418..>1502	CDD:206637	22/92 (24%)
		Cadherin_repeat	1617..1710	CDD:206637
Cdhr3	NP_001019649.1	Cadherin_repeat	30..128	CDD:206637	30/114 (26%)
		Cadherin_repeat	141..231	CDD:206637	25/108 (23%)
		Cadherin_repeat	242..341	CDD:206637	31/106 (29%)
		Cadherin_repeat	349..456	CDD:206637	23/107 (21%)
		Cadherin_repeat	465..561	CDD:206637	24/105 (23%)
		Cadherin_repeat	571..679	CDD:206637	25/112 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	743..763
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100