DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad88C and CDH23

DIOPT Version :9

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:NP_071407.4 Gene:CDH23 / 64072 HGNCID:13733 Length:3354 Species:Homo sapiens


Alignment Length:1978 Identity:580/1978 - (29%)
Similarity:915/1978 - (46%) Gaps:278/1978 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 SSISIQVIILTTLISLVASNRPPRFAIDGQSEIVLRLKESPETKVGTLIYTLKGYDPD---NDPL 98
            |::.:.:.:|.      .::..|||  |..|:..:.:.|  :..||..:.|:|.:|||   |..:
Human  1400 STVKVYITVLD------ENDNSPRF--DFTSDSAVSIPE--DCPVGQRVATVKAWDPDAGSNGQV 1454

  Fly    99 TFGKRNSHDSEIIRIENTGGNEAKIFLAKELDRELQDEYAIVLTLTD----SHYSDHNYVTQSFL 159
            .|...:.:.:....|..|..:..::|:|:.||||..|.|.:.:..:|    ....||  :.|..:
Human  1455 VFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDH--ILQVTI 1517

  Fly   160 LLVEDINDNVPTF-LPYQNAIEIPEGSAPG-VVSTLEATDADEGAYGQVVYYLQELDGDNDV-FS 221
            |   |||||.|.. .|:...:.:.|....| .|..:.|||.|.|....:.||:.|  |:.|: |.
Human  1518 L---DINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE--GNKDMAFR 1577

  Fly   222 IATHQGKGILRLQKELDYERKSLYQLRVLAIDRANQGPINTGTAAILVKVKDLEDQPPEF----V 282
            :....|: |.......|.||:|.|.|.....|...  |..:.|..:.|.:.|..|..|.|    .
Human  1578 MDRISGE-IATRPAPPDRERQSFYHLVATVEDEGT--PTLSATTHVYVTIVDENDNAPMFQQPHY 1639

  Fly   283 EVQAVARIAEDAP--VGTKVLRVRAIDGDRGINNPIAYSLEANDL---FDINPHTGIVHTLTKLD 342
            ||     :.::.|  :.|.::.::|:|.|.|.|..:.|::.|.::   |.|:.|.|::....:||
Human  1640 EV-----LLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699

  Fly   343 REEQSDQVNGAHILRISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPTFGETVYR--CEVNEN 405
            .|..    :|.:.|.::||:.....:....:|  |.|.|.|:|:||.:|||... |.  .||.|.
Human  1700 YEIS----HGRYTLIVTATDQCPILSHRLTST--TTVLVNVNDINDNVPTFPRD-YEGPFEVTEG 1757

  Fly   406 AQTNTPLNFIDEEVQNVVFDHDEGNNGTFRLFL---DPPNDLFEIVPELAVNEANFMLRVKNSKS 467
            ........|:       ..|.|.|.||.....:   ||       :.|..::....:|||:....
Human  1758 QPGPRVWTFL-------AHDRDSGPNGQVEYSIMDGDP-------LGEFVISPVEGVLRVRKDVE 1808

  Fly   468 LDFEQFTEVNFTIFAREVDEPSRWSSAHVQIFIRDQNDNFPEFSQTIYNASVLENSEQDTIITHV 532
            ||.|.....|.||.||:...|...|:..|.|.:.|.|||.|.......|.::.|||...:.:.||
Human  1809 LDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHV 1873

  Fly   533 QAVDVDSGDYGTMGIRYTNLRGGIAHLLNLNPITGVITIKQAGGTAFDREIISRHYLTVEAIDNA 597
            .|.|.|||....:....|  .|.......:|..||::|:.:    ..|||.|..:.||:...||.
Human  1874 LASDADSGCNARLTFNIT--AGNRERAFFINATTGIVTVNR----PLDRERIPEYKLTISVKDNP 1932

  Fly   598 GQ---GNRNTAQIIVDILDVNDNAPTFPQRQYETKLLENQAEFETPL-----QLEARDADLNGTE 654
            ..   ..|:...:::.:.|.|||.|.|.:..|:.:::|| :...|||     .:.|.|||.:  .
Human  1933 ENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMEN-SPAGTPLTVLNGPILALDADQD--I 1994

  Fly   655 NSQVTYEIVEGLYRSNFTIDPQSGLLRPVHSFDFEELVDGSSRRSDPYTGGSFSIREIDLLVRAR 719
            .:.|||::: |.....|.|:..:|:: .|.|   ..::|..          :||...::||:.|.
Human  1995 YAVVTYQLL-GAQSGLFDINSSTGVV-TVRS---GVIIDRE----------AFSPPILELLLLAE 2044

  Fly   720 DSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPNNVVVY 784
            |.|  :|::...:||.:.|.|||.|.|..:.....:.|:.|.|.|||||||.|.| |..|..:||
Human  2045 DIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDED-SGLNGELVY 2106

  Fly   785 RIQTGAGDKFIINSETGVISVAHGANLDPDLTESKRSLYTLSVIALDGGLGNSQLMTTCTVNISI 849
            ||:.||.|:|:|:..||||.|.: |.:|.:..||    |.|:|:|.|  .|...|..|..|.|.|
Human  2107 RIEAGAQDRFLIHLVTGVIRVGN-ATIDREEQES----YRLTVVATD--RGTVPLSGTAIVTILI 2164

  Fly   850 QDVN-NKPPVLKEMPALQILENTPVGTLVYRIQATDLDHKAILRYKLNPE---HCEG---RTEEG 907
            .|:| ::|..|..:..:.:||:...||::..|.|.|.|        |||:   |..|   :.:..
Human  2165 DDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--------LNPKLEYHIVGIVAKDDTD 2221

  Fly   908 ALVKSSEYDFLGAFEVDSIEGTLKVVKLLDRERVEHIKLAITVEDLAA---AKGRQIAEGFLSIQ 969
            .||.:.|    .||.|:...|::.|...::||.|...::.::|.|.|:   .:...:....|::.
Human  2222 RLVPNQE----DAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVN 2282

  Fly   970 VLDENDNNPKFR---LPFYRQSITENSINGAMIVNVLASDVDK--NRTITYALEG--NPTYRSLM 1027
            |||.|||.|:|:   :.:|.:.|.|.:..|..::.|.|.|.||  |..:||.|..  .|.|..|.
Human  2283 VLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2347

  Fly  1028 HLDPQTGEIVVASKIDHEQHQWLNFSVRATDSGIPARSSLVDVYITVLDENDNNPYFVGGSKNYT 1092
              |...|:::....:|:|:..||||:|||:|:|.|.|::.:.||:.::|.|||||.|...|....
Human  2348 --DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEA 2410

  Fly  1093 ISENAAPGTRVATLQAGDADSGDFGKITFLMDRISSQGKFTIDADTGVLTVADRLDRESKDSYNL 1157
            :.|:...||.:.|:.|.|||||:|..|.:.:.  ..:.||.|:..||.:.|...||||.||.|.|
Human  2411 VFEDVPVGTIILTVTATDADSGNFALIEYSLG--DGESKFAINPTTGDIYVLSSLDREKKDHYIL 2473

  Fly  1158 VIEAWDNYQFGFLAGESRNAFKQVFISILDENDNPPEVDLPMSCVLITEYHELHERVASIVGKDA 1222
            ...|.||.  |.:|...|....||.|.:||.||..|:...|.....:.|.......|.:::..|.
Human  2474 TALAKDNP--GDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQ 2536

  Fly  1223 DDPTTPNGRLDFAITRGNKDGM-FELRQIDAWNAQIFASKSLRNRYGNYSLTITTRDMGLPANIV 1286
            |:  .|||.|.:::     :|. .|...:|..:..:...:.|:: |..:|||:...|.|.|....
Human  2537 DE--GPNGELTYSL-----EGPGVEAFHVDMDSGLVTTQRPLQS-YEKFSLTVVATDGGEPPLWG 2593

  Fly  1287 HNTLDICVSDFNDHAPVFVRPLHNTTVRIPENATVGTLILQAYASDGDMGQNALVRYR-LKPDPL 1350
            ...|.:.|.|.||:.||||||.:.|.:.|.|...:.:.:.:.||:|.|.|.|..|||. ||....
Human  2594 TTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGN 2658

  Fly  1351 GSYKMFEVDGSTGELFLKEQLNREKQKIHEIRIEAYDQGLPTSLSSDLDLTIYVRNVNDYEPQFM 1415
            ..::.|.:|..:|.:...::|:||.|.::.:.:.|.|.|.|....:...|.:.:.:::|.||.|:
Human  2659 RDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFV 2723

  Fly  1416 --------VNEISVNFTEHSDPGSERIKLPDTIDKDQLELDDPNDTPSQVCYFIVNGNEAGYFRL 1472
                    ...::|  .|||..|:....:...:|.|    :.||   :.|.|||..|||...|.|
Human  2724 RPPKGSPQYQLLTV--PEHSPRGTLVGNVTGAVDAD----EGPN---AIVYYFIAAGNEEKNFHL 2779

  Fly  1473 DPETHILTVDRELDREVIANFTLYVRATENCRNDSISGGEKRRRMGIEINNRLGGIVHNQQFGYD 1537
            .|:..:|.: |:||||..|.|:..|:|:.|                                   
Human  2780 QPDGCLLVL-RDLDREREAIFSFIVKASSN----------------------------------- 2808

  Fly  1538 RFKHSRQLRSTESNEYGPEDAELLSYEAYDSSQEDPTGGLATTHPELDSTVIKVKVRVLDINDNP 1602
                                          .|...|.|...|.....|.|:.:|:|.:.||||.|
Human  2809 ------------------------------RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQP 2843

  Fly  1603 PRFRSKIFTGGITTNADFGLKFMRVEATDADEGDNGRIGYYQVGEIR--QTLSEGLENVRKAPFL 1665
            |||....:|.|:.|:|..|.:.::|.|.|||.|:|..: :|.:..|.  :.|:...|:|.:. |.
Human  2844 PRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLV-FYSILAIHYFRALANDSEDVGQV-FT 2906

  Fly  1666 LDQETG-----EVQLNFDPQKGMKGYFDFVVLANDTSGMKDVAHVFIYLLREDQKVRFVFRLQPD 1725
            :....|     ::.:.:.|     |||...::|.|.:|..|.|.:.||:||:||:|:.|....||
Human  2907 MGSMDGILRTFDLFMAYSP-----GYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIVINEIPD 2966

  Fly  1726 ELRSRVDSFRDTLSNITESIVNIDEIKVHENKDGSVDKTKTDLYMHLVEREDNSIYEVSEVLKLI 1790
            .:|...:.|...|||||.:|||.|.::.|.:|.|.|:..:|:|.:|:|.|:.|.|.:|..|:::|
Human  2967 RVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMI 3031

  Fly  1791 DSHIESLNGLFKELNVLDTQAAEAQLLTAGPSRGPLFVWLIFTNLFLATLLVVTIALCASQRNGY 1855
            |.:.|.|..||:..||||.|.|.:..|....|...:.:.::...||||.:|.|.:..  ..|..:
Human  3032 DENKEQLRNLFRNYNVLDVQPAISVRLPDDMSALQMAIIVLAILLFLAAMLFVLMNW--YYRTVH 3094

  Fly  1856 RRQLRAAKVNIFRGHSSMSLQDAQEPATRVPNTNKHSVQGSNPIWLKGYDNEWFKSEESGSIGGH 1920
            :|:|:|...........:.:.|       :|||||:|..|:||:||    :.:.::.|..:...|
Human  3095 KRKLKAIVAGSAGNRGFIDIMD-------MPNTNKYSFDGANPVWL----DPFCRNLELAAQAEH 3148

  Fly  1921 DSLDDNFLAVATQDMHETLKGTAKLFNN 1948
            :           .|:.|.|...|.|:|:
Human  3149 E-----------DDLPENLSEIADLWNS 3165

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 27/98 (28%)
Cadherin_repeat 179..276 CDD:206637 27/98 (28%)
Cadherin_repeat 287..388 CDD:206637 26/105 (25%)
Cadherin_repeat 397..506 CDD:206637 30/113 (27%)
Cadherin_repeat 514..617 CDD:206637 28/105 (27%)
Cadherin_repeat 625..742 CDD:206637 32/121 (26%)
Cadherin_repeat 751..853 CDD:206637 44/101 (44%)
Cadherin_repeat 865..976 CDD:206637 32/119 (27%)
Cadherin_repeat 985..1080 CDD:206637 35/98 (36%)
Cadherin_repeat 1090..1191 CDD:206637 38/100 (38%)
CA 1221..1302 CDD:214520 22/81 (27%)
Cadherin_repeat 1312..1409 CDD:206637 25/97 (26%)
Cadherin_repeat 1418..>1502 CDD:206637 29/83 (35%)
Cadherin_repeat 1617..1710 CDD:206637 27/99 (27%)
CDH23NP_071407.4 Cadherin_repeat 42..128 CDD:206637
Cadherin_repeat 136..231 CDD:206637
Cadherin_repeat 240..344 CDD:206637
Cadherin_repeat 352..456 CDD:206637
Cadherin_repeat 465..557 CDD:206637
Cadherin_repeat 566..667 CDD:206637
Cadherin_repeat 676..774 CDD:206637
Cadherin_repeat 782..886 CDD:206637
Cadherin_repeat 894..990 CDD:206637
Cadherin_repeat 999..1098 CDD:206637
Cadherin_repeat 1106..1203 CDD:206637
Cadherin_repeat 1218..1308 CDD:206637
Cadherin_repeat 1317..1414 CDD:206637 2/19 (11%)
Cadherin_repeat 1426..1523 CDD:206637 28/103 (27%)
Cadherin_repeat 1533..1630 CDD:206637 27/101 (27%)
Cadherin_repeat 1638..1740 CDD:206637 29/112 (26%)
Cadherin_repeat 1752..1847 CDD:206637 29/108 (27%)
Cadherin_repeat 1855..1955 CDD:206637 28/105 (27%)
Cadherin_repeat 1963..2065 CDD:206637 32/121 (26%)
Cadherin_repeat 2075..2169 CDD:206637 44/101 (44%)
Cadherin_repeat 2180..2289 CDD:206637 32/120 (27%)
Cadherin_repeat 2301..2398 CDD:206637 35/98 (36%)
Cadherin_repeat 2406..2504 CDD:206637 38/101 (38%)
Cadherin_repeat 2513..2607 CDD:206637 23/101 (23%)
Cadherin_repeat 2620..2718 CDD:206637 25/97 (26%)
Cadherin_repeat 2735..2841 CDD:206637 40/180 (22%)
Cadherin_repeat 2850..2951 CDD:206637 30/107 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 170 1.000 Domainoid score I3783
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12697at33208
OrthoFinder 1 1.000 - - FOG0007436
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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